YGR087C / PDC6

Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR087C / PDC6

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-2.93|P-value:9.15E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.66|P-value:7.08E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.09|P-value:5.16E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.29|P-value:3.06E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.51|P-value:1.29E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:2.98|P-value:9.87E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.57|P-value:1.02E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.28|P-value:3.22E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.17|P-value:4.86E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-4.13|P-value:5.91E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.14|P-value:4.30E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.39|P-value:2.14E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.07|P-value:7.10E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.28|P-value:3.20E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.06|P-value:5.78E-4 ID:SGTC_1548|Compound:st061468|FD-Score:-3.02|P-value:6.55E-4 ID:SGTC_1611|Compound:st001856|FD-Score:-3.11|P-value:4.68E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-3.11|P-value:4.76E-4 ID:SGTC_1616|Compound:st002734|FD-Score:4.66|P-value:5.70E-7 ID:SGTC_1652|Compound:st011932|FD-Score:-3.02|P-value:6.67E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.63|P-value:7.81E-5 ID:SGTC_1791|Compound:st048313|FD-Score:3.28|P-value:3.22E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.40|P-value:2.05E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.79|P-value:2.88E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.18|P-value:4.77E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.57|P-value:1.01E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.89|P-value:1.88E-5 ID:SGTC_2056|Compound:5235370|FD-Score:7.02|P-value:1.09E-13 ID:SGTC_2265|Compound:7929201|FD-Score:-3.64|P-value:5.66E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.59|P-value:7.06E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.99|P-value:1.58E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.87|P-value:2.81E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:4.65|P-value:6.13E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-3.16|P-value:3.94E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.10|P-value:6.27E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.29|P-value:3.94E-6 ID:SGTC_2873|Compound:9040596|FD-Score:3.17|P-value:4.96E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.36|P-value:2.33E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.91|P-value:1.68E-5 ID:SGTC_2968|Compound:9090663|FD-Score:3.47|P-value:1.51E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.83|P-value:3.33E-5 ID:SGTC_3303|Compound:9125618|FD-Score:3.78|P-value:4.08E-5 ID:SGTC_3305|Compound:9127027|FD-Score:4.25|P-value:4.80E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.93|P-value:9.15E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.66|P-value:7.08E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.09|P-value:5.16E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.29|P-value:3.06E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.51|P-value:1.29E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:2.98|P-value:9.87E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.57|P-value:1.02E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.28|P-value:3.22E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.17|P-value:4.86E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-4.13|P-value:5.91E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.14|P-value:4.30E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.39|P-value:2.14E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.07|P-value:7.10E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.28|P-value:3.20E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.06|P-value:5.78E-4 ID:SGTC_1548|Compound:st061468|FD-Score:-3.02|P-value:6.55E-4 ID:SGTC_1611|Compound:st001856|FD-Score:-3.11|P-value:4.68E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-3.11|P-value:4.76E-4 ID:SGTC_1616|Compound:st002734|FD-Score:4.66|P-value:5.70E-7 ID:SGTC_1652|Compound:st011932|FD-Score:-3.02|P-value:6.67E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.63|P-value:7.81E-5 ID:SGTC_1791|Compound:st048313|FD-Score:3.28|P-value:3.22E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.40|P-value:2.05E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.79|P-value:2.88E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.18|P-value:4.77E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.57|P-value:1.01E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.89|P-value:1.88E-5 ID:SGTC_2056|Compound:5235370|FD-Score:7.02|P-value:1.09E-13 ID:SGTC_2265|Compound:7929201|FD-Score:-3.64|P-value:5.66E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.59|P-value:7.06E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.99|P-value:1.58E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.87|P-value:2.81E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:4.65|P-value:6.13E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-3.16|P-value:3.94E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.10|P-value:6.27E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.29|P-value:3.94E-6 ID:SGTC_2873|Compound:9040596|FD-Score:3.17|P-value:4.96E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.36|P-value:2.33E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.91|P-value:1.68E-5 ID:SGTC_2968|Compound:9090663|FD-Score:3.47|P-value:1.51E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.83|P-value:3.33E-5 ID:SGTC_3303|Compound:9125618|FD-Score:3.78|P-value:4.08E-5 ID:SGTC_3305|Compound:9127027|FD-Score:4.25|P-value:4.80E-6

Top fitness defect scores for YGR087C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2056 5235370 7.02 200.0 µM 1.09E-13 7 1.14E-12
2 SGTC_1616 st002734 4.66 56.1 µM 5.70E-7 12 1.55E-6
3 SGTC_2586 curcumin 4.65 80.0 µM 6.13E-7 iron homeostasis 37 1.65E-6
4 SGTC_2827 7993847 4.29 71.4 µM 3.94E-6 16 9.08E-6
5 SGTC_3305 9127027 4.25 53.8 µM 4.80E-6 11 1.09E-5
6 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.99 63.6 µM 1.58E-5 39 3.25E-5
7 SGTC_2564 betulinic acid 3.87 100.0 µM 2.81E-5 32 5.50E-5
8 SGTC_3039 9090270 3.83 49.5 µM 3.33E-5 RPP1 & pyrimidine depletion 12 6.42E-5
9 SGTC_3303 9125618 3.78 40.6 µM 4.08E-5 53 7.73E-5
10 SGTC_108 0509-0257 3.66 621.1 µM 7.08E-5 64 1.28E-4
11 SGTC_1726 st035556 3.63 14.6 µM 7.81E-5 46 1.40E-4
12 SGTC_2049 5262831 3.57 67.2 µM 1.01E-4 40 1.78E-4
13 SGTC_1133 3473-0247 3.57 50.0 µM 1.02E-4 RSC complex & mRNA processing 69 1.79E-4
14 SGTC_274 sirtinol 3.51 40.1 µM 1.29E-4 35 2.22E-4
15 SGTC_2968 9090663 3.47 33.4 µM 1.51E-4 50 2.57E-4
16 SGTC_1834 st055981 3.40 52.8 µM 2.05E-4 RPP1 & pyrimidine depletion 52 3.41E-4
17 SGTC_1323 1348-1351 3.39 11.2 µM 2.14E-4 20 3.55E-4
18 SGTC_2933 9026794 3.36 32.5 µM 2.33E-4 50 3.83E-4
19 SGTC_229 benomyl 3.29 22.9 µM 3.06E-4 tubulin folding & SWR complex 49 4.93E-4
20 SGTC_1341 1486-1360 3.28 280.0 µM 3.20E-4 51 5.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 7.08E-18 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.113 5.62E-11 YOR019W YOR019W hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.112 9.40E-11 YDR333C RQC1 hom Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC
0.110 1.43E-10 YMR192W GYL1 hom Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress
0.107 5.90E-10 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.105 1.05E-9 YLR124W_d YLR124W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 3.63E-9 YLL019C KNS1 hom Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation
0.098 1.35E-8 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.094 4.89E-8 YLR285W NNT1 hom S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination
0.094 5.37E-8 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.089 2.27E-7 YNR071C_p YNR071C_p hom Putative aldose 1-epimerase
0.089 2.36E-7 YGL065C ALG2 het Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
0.085 7.68E-7 YCR017C CWH43 hom Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
0.084 1.18E-6 YKL153W_d YKL153W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.083 1.38E-6 YHL015W-A_p YHL015W-A_p hom Putative protein of unknown function