YGR097W / ASK10

Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR097W / ASK10

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.93|P-value:2.41E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.03|P-value:8.46E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.18|P-value:6.23E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.02|P-value:2.12E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.06|P-value:7.61E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.57|P-value:1.13E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:-3.92|P-value:2.54E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.61|P-value:3.62E-9 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.72|P-value:6.08E-5 ID:SGTC_1629|Compound:st005085|FD-Score:-3.24|P-value:3.99E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.05|P-value:9.63E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-3.73|P-value:5.68E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.78|P-value:4.74E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.08|P-value:1.22E-5 ID:SGTC_2106|Compound:5357045|FD-Score:3.76|P-value:6.63E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.30|P-value:3.97E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.07|P-value:7.32E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.69|P-value:8.56E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.44|P-value:1.84E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.08|P-value:8.86E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.07|P-value:9.08E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.46|P-value:1.70E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.04|P-value:8.10E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-3.00|P-value:9.26E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.93|P-value:2.41E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.03|P-value:8.46E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.18|P-value:6.23E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.02|P-value:2.12E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.06|P-value:7.61E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.57|P-value:1.13E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:-3.92|P-value:2.54E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.61|P-value:3.62E-9 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.72|P-value:6.08E-5 ID:SGTC_1629|Compound:st005085|FD-Score:-3.24|P-value:3.99E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.05|P-value:9.63E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-3.73|P-value:5.68E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.78|P-value:4.74E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.08|P-value:1.22E-5 ID:SGTC_2106|Compound:5357045|FD-Score:3.76|P-value:6.63E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.30|P-value:3.97E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.07|P-value:7.32E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.69|P-value:8.56E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.44|P-value:1.84E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.08|P-value:8.86E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.07|P-value:9.08E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.46|P-value:1.70E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.04|P-value:8.10E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-3.00|P-value:9.26E-4

Top fitness defect scores for YGR097W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1068 loratadine 4.02 26.9 µM 2.12E-5 21 2.89E-5
2 SGTC_2106 5357045 3.76 167.3 µM 6.63E-5 23 8.66E-5
3 SGTC_2546 rhodinyl acetate 3.69 100.0 µM 8.56E-5 18 1.11E-4
4 SGTC_2109 5483026 3.30 200.0 µM 3.97E-4 RSC complex & mRNA processing 61 4.82E-4
5 SGTC_509 pifithrin 3.18 175.0 µM 6.23E-4 mitochondrial processes 17 7.44E-4
6 SGTC_2656 pseudo-anisatin 3.08 100.0 µM 8.86E-4 11 0.00104
7 SGTC_2698 st077697 3.07 67.5 µM 9.08E-4 41 0.00107
8 SGTC_1679 4130-1276 3.05 6.7 µM 9.63E-4 Golgi 120 0.00113
9 SGTC_510 ag-490 3.02 170.0 µM 0.00107 18 0.00125
10 SGTC_2007 4011539 3.02 71.8 µM 0.00108 cell wall signaling 111 0.00127
11 SGTC_479 n-linoleoylglycine 2.97 10.0 µM 0.00126 35 0.00147
12 SGTC_1870 st057514 2.93 26.5 µM 0.00147 RSC & ERG11 72 0.00170
13 SGTC_2528 xanthyletin 2.81 44.8 µM 0.00215 74 0.00245
14 SGTC_1601 4'-hydroxyflavanone 2.71 55.5 µM 0.00302 RPP1 & pyrimidine depletion 102 0.00341
15 SGTC_2872 9044037 2.70 26.0 µM 0.00305 38 0.00344
16 SGTC_499 genistein 2.70 192.0 µM 0.00310 22 0.00348
17 SGTC_2227 7312221 2.68 64.1 µM 0.00326 27 0.00366
18 SGTC_2059 5238311 2.68 157.0 µM 0.00328 95 0.00368
19 SGTC_1756 st041558 2.59 35.5 µM 0.00436 64 0.00484
20 SGTC_6 0844-0013 2.58 19.8 µM 0.00451 290 0.00501

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.308 7.73E-75 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.241 1.52E-45 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.218 2.59E-37 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.210 8.40E-35 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.200 1.19E-31 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.197 7.78E-31 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.196 1.88E-30 YKL174C TPO5 hom Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
0.195 4.91E-30 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.193 1.46E-29 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.193 1.65E-29 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.193 1.70E-29 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.188 3.65E-28 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.188 4.56E-28 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.185 4.09E-27 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.183 1.03E-26 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress