YGR100W / MDR1

Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR100W / MDR1

Click on Significant Values for Screen Details ID:SGTC_278|Compound:4092-0821|FD-Score:3.31|P-value:7.83E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:7.66|P-value:1.36E-13 ID:SGTC_313|Compound:3474-0040|FD-Score:3.40|P-value:5.81E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.67|P-value:2.27E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.69|P-value:3.71E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:3.37|P-value:6.51E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.56|P-value:3.36E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.60|P-value:2.90E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.14|P-value:2.39E-9 ID:SGTC_485|Compound:niflumic acid|FD-Score:-3.36|P-value:6.87E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.25|P-value:9.56E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.51|P-value:4.25E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.86|P-value:1.14E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.82|P-value:1.35E-4 ID:SGTC_1905|Compound:st060207|FD-Score:4.27|P-value:2.31E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.39|P-value:6.07E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.40|P-value:6.07E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.26|P-value:9.65E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.82|P-value:1.34E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.53|P-value:3.95E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.44|P-value:5.26E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.60|P-value:3.08E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.86|P-value:1.12E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.89|P-value:1.02E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.34|P-value:7.21E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.31|P-value:7.83E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:7.66|P-value:1.36E-13 ID:SGTC_313|Compound:3474-0040|FD-Score:3.40|P-value:5.81E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.67|P-value:2.27E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.69|P-value:3.71E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:3.37|P-value:6.51E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.56|P-value:3.36E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.60|P-value:2.90E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.14|P-value:2.39E-9 ID:SGTC_485|Compound:niflumic acid|FD-Score:-3.36|P-value:6.87E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.25|P-value:9.56E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.51|P-value:4.25E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.86|P-value:1.14E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.82|P-value:1.35E-4 ID:SGTC_1905|Compound:st060207|FD-Score:4.27|P-value:2.31E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.39|P-value:6.07E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.40|P-value:6.07E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.26|P-value:9.65E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.82|P-value:1.34E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.53|P-value:3.95E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.44|P-value:5.26E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.60|P-value:3.08E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.86|P-value:1.12E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.89|P-value:1.02E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.34|P-value:7.21E-4

Top fitness defect scores for YGR100W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_309 k408-0051 7.66 1.5 µM 1.36E-13 6 9.38E-15
2 SGTC_453 enantio-paf c16 6.14 10.0 µM 2.39E-9 42 4.25E-10
3 SGTC_319 1348-1596 4.69 45.5 µM 3.71E-6 RSC & ERG11 9 1.33E-6
4 SGTC_1905 st060207 4.27 84.5 µM 2.31E-5 6 9.90E-6
5 SGTC_3008 9078912 3.89 71.4 µM 1.02E-4 20 5.04E-5
6 SGTC_2987 9018338 3.86 71.4 µM 1.12E-4 RPP1 & pyrimidine depletion 18 5.56E-5
7 SGTC_1490 4089-0339 3.86 670.0 nM 1.14E-4 9 5.65E-5
8 SGTC_2621 lithochol-11-enic acid 3.82 100.0 µM 1.34E-4 28 6.75E-5
9 SGTC_1904 st060225 3.82 78.0 µM 1.35E-4 24 6.79E-5
10 SGTC_315 k915-0449 3.67 187.0 µM 2.27E-4 65 1.20E-4
11 SGTC_445 e6 berbamine 3.60 66.0 µM 2.90E-4 NEO1-PIK1 134 1.57E-4
12 SGTC_426 0988-0037 3.56 14.6 µM 3.36E-4 ERAD & cell cycle 49 1.85E-4
13 SGTC_313 3474-0040 3.40 5.0 µM 5.81E-4 NEO1-PIK1 95 3.35E-4
14 SGTC_1928 4'-methoxychalcone 3.39 40.3 µM 6.07E-4 24 3.52E-4
15 SGTC_374 0880-0231 3.37 82.3 µM 6.51E-4 iron homeostasis 50 3.80E-4
16 SGTC_3206 9114350 3.34 49.5 µM 7.21E-4 39 4.25E-4
17 SGTC_278 4092-0821 3.31 23.9 µM 7.83E-4 plasma membrane duress 71 4.65E-4
18 SGTC_1294 1000-1494 3.25 117.0 µM 9.56E-4 47 5.78E-4
19 SGTC_2961 9083290 3.23 32.5 µM 0.00100 38 6.09E-4
20 SGTC_2620 irigenin 3.21 100.0 µM 0.00107 68 6.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.245 4.01E-47 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.223 3.65E-39 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.192 2.34E-29 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.191 4.68E-29 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.190 1.10E-28 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.133 1.18E-14 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.127 1.62E-13 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.124 5.71E-13 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.123 7.32E-13 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.122 1.25E-12 YGR199W PMT6 hom Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
0.119 5.02E-12 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.119 5.05E-12 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.118 6.39E-12 YKL161C KDX1 hom Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
0.114 3.10E-11 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.107 5.27E-10 YMR135C GID8 hom Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START