YGR117C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR117C / YGR117C

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.21|P-value:9.99E-7 ID:SGTC_41|Compound:0478-0632|FD-Score:3.26|P-value:1.11E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-2.97|P-value:4.96E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.44|P-value:5.02E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.89|P-value:2.44E-8 ID:SGTC_594|Compound:1487-1584|FD-Score:3.24|P-value:1.20E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.78|P-value:9.43E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:-2.98|P-value:4.63E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.32|P-value:1.10E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:2.79|P-value:7.71E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.06|P-value:3.37E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.27|P-value:1.09E-4 ID:SGTC_2030|Compound:5175110|FD-Score:2.73|P-value:9.76E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.95|P-value:4.10E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.26|P-value:1.11E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.44|P-value:6.62E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.08|P-value:3.18E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.05|P-value:2.73E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.17|P-value:2.13E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.79|P-value:9.26E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.67|P-value:2.20E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.96|P-value:4.01E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.32|P-value:1.14E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.75|P-value:1.11E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.52|P-value:3.36E-5 ID:SGTC_2866|Compound:9034245|FD-Score:2.80|P-value:7.40E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.07|P-value:2.52E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.66|P-value:2.31E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:4.21|P-value:9.99E-7 ID:SGTC_41|Compound:0478-0632|FD-Score:3.26|P-value:1.11E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-2.97|P-value:4.96E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.44|P-value:5.02E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.89|P-value:2.44E-8 ID:SGTC_594|Compound:1487-1584|FD-Score:3.24|P-value:1.20E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.78|P-value:9.43E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:-2.98|P-value:4.63E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.32|P-value:1.10E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:2.79|P-value:7.71E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.06|P-value:3.37E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.27|P-value:1.09E-4 ID:SGTC_2030|Compound:5175110|FD-Score:2.73|P-value:9.76E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.95|P-value:4.10E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.26|P-value:1.11E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.44|P-value:6.62E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.08|P-value:3.18E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.05|P-value:2.73E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.17|P-value:2.13E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.79|P-value:9.26E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.67|P-value:2.20E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.96|P-value:4.01E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.32|P-value:1.14E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.75|P-value:1.11E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.52|P-value:3.36E-5 ID:SGTC_2866|Compound:9034245|FD-Score:2.80|P-value:7.40E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.07|P-value:2.52E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.66|P-value:2.31E-5

Top fitness defect scores for YGR117C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_39 0986-0283 4.21 58.4 µM 9.99E-7 calcium & mitochondrial duress 30 1.30E-5
2 SGTC_2629 bisabolol 3.79 100.0 µM 9.26E-6 26 7.65E-5
3 SGTC_807 1315-0151 3.78 48.0 µM 9.43E-6 33 7.76E-5
4 SGTC_2757 clomiphene 3.75 4.2 µM 1.11E-5 fatty acid desaturase (OLE1) 46 8.82E-5
5 SGTC_2831 7999036 3.52 19.5 µM 3.36E-5 61 2.14E-4
6 SGTC_284 0988-0104 3.44 32.6 µM 5.02E-5 heme requiring 20 2.95E-4
7 SGTC_1948 st076329 3.27 66.6 µM 1.09E-4 54 5.46E-4
8 SGTC_41 0478-0632 3.26 82.6 µM 1.11E-4 62 5.56E-4
9 SGTC_2389 9091542 3.26 195.5 µM 1.11E-4 iron homeostasis 63 5.56E-4
10 SGTC_594 1487-1584 3.24 10.8 µM 1.20E-4 45 5.91E-4
11 SGTC_2933 9026794 3.07 32.5 µM 2.52E-4 72 0.00107
12 SGTC_2620 irigenin 3.05 100.0 µM 2.73E-4 78 0.00114
13 SGTC_2640 pentamidine 2.96 10.4 µM 4.01E-4 mitochondrial processes 79 0.00155
14 SGTC_2375 9072683 2.95 200.0 µM 4.10E-4 mitochondrial processes 62 0.00158
15 SGTC_2866 9034245 2.80 58.4 µM 7.40E-4 50 0.00253
16 SGTC_1140 3229-1848 2.79 3.0 µM 7.71E-4 44 0.00262
17 SGTC_2030 5175110 2.73 200.0 µM 9.76E-4 Golgi 79 0.00317
18 SGTC_1607 st000305 2.71 50.6 µM 0.00105 74 0.00335
19 SGTC_2384 9036245 2.68 200.0 µM 0.00116 96 0.00364
20 SGTC_367 0335-0881 2.61 7.1 µM 0.00152 ubiquinone biosynthesis & proteasome 183 0.00450

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 5.67E-20 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.154 2.48E-19 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.146 1.75E-17 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.145 3.27E-17 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.144 5.34E-17 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.143 6.55E-17 YJL002C OST1 het Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.142 1.78E-16 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.132 1.83E-14 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene
0.124 5.40E-13 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.118 7.96E-12 YIL173W VTH1 hom Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
0.118 8.86E-12 YDR242W AMD2 hom Putative amidase
0.112 6.55E-11 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.112 6.99E-11 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.111 1.35E-10 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.103 1.85E-9 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS