YGR121W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR121W-A / YGR121W-A

Click on Significant Values for Screen Details ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.06|P-value:7.37E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.37|P-value:2.30E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.14|P-value:5.75E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.76|P-value:4.65E-16 ID:SGTC_296|Compound:1222-0039|FD-Score:4.77|P-value:3.98E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:3.59|P-value:1.03E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.65|P-value:7.89E-5 ID:SGTC_510|Compound:ag-490|FD-Score:3.61|P-value:9.25E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.85|P-value:3.42E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.08|P-value:6.94E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.97|P-value:1.34E-7 ID:SGTC_801|Compound:0866-0028|FD-Score:3.37|P-value:2.45E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.24|P-value:3.98E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.96|P-value:2.11E-5 ID:SGTC_1397|Compound:3532-0190|FD-Score:4.86|P-value:2.51E-7 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:6.40|P-value:1.69E-11 ID:SGTC_1670|Compound:st016595|FD-Score:3.42|P-value:2.03E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.79|P-value:4.44E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.30|P-value:3.25E-4 ID:SGTC_1831|Compound:st055328|FD-Score:4.05|P-value:1.40E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.01|P-value:9.13E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-2.98|P-value:9.98E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.05|P-value:7.77E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.85|P-value:3.40E-5 ID:SGTC_2083|Compound:5306046|FD-Score:4.22|P-value:6.18E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-6.53|P-value:6.12E-12 ID:SGTC_2370|Compound:9071495|FD-Score:3.59|P-value:1.02E-4 ID:SGTC_2476|Compound:5806916|FD-Score:5.03|P-value:9.90E-8 ID:SGTC_2483|Compound:5729050|FD-Score:5.64|P-value:2.64E-9 ID:SGTC_2485|Compound:5633444|FD-Score:-3.06|P-value:7.52E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.68|P-value:7.04E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:4.29|P-value:4.46E-6 ID:SGTC_2852|Compound:9023854|FD-Score:4.45|P-value:2.04E-6 ID:SGTC_2921|Compound:7974240|FD-Score:4.08|P-value:1.23E-5 ID:SGTC_3008|Compound:9078912|FD-Score:3.46|P-value:1.71E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.64|P-value:8.18E-5 ID:SGTC_3047|Compound:9092122|FD-Score:4.90|P-value:1.97E-7 ID:SGTC_3170|Compound:9103054|FD-Score:4.69|P-value:6.09E-7 ID:SGTC_3233|Compound:9132340|FD-Score:3.56|P-value:1.14E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.06|P-value:7.37E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.37|P-value:2.30E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.14|P-value:5.75E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.76|P-value:4.65E-16 ID:SGTC_296|Compound:1222-0039|FD-Score:4.77|P-value:3.98E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:3.59|P-value:1.03E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.65|P-value:7.89E-5 ID:SGTC_510|Compound:ag-490|FD-Score:3.61|P-value:9.25E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.85|P-value:3.42E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.08|P-value:6.94E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.97|P-value:1.34E-7 ID:SGTC_801|Compound:0866-0028|FD-Score:3.37|P-value:2.45E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.24|P-value:3.98E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.96|P-value:2.11E-5 ID:SGTC_1397|Compound:3532-0190|FD-Score:4.86|P-value:2.51E-7 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:6.40|P-value:1.69E-11 ID:SGTC_1670|Compound:st016595|FD-Score:3.42|P-value:2.03E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.79|P-value:4.44E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.30|P-value:3.25E-4 ID:SGTC_1831|Compound:st055328|FD-Score:4.05|P-value:1.40E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.01|P-value:9.13E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-2.98|P-value:9.98E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.05|P-value:7.77E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.85|P-value:3.40E-5 ID:SGTC_2083|Compound:5306046|FD-Score:4.22|P-value:6.18E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-6.53|P-value:6.12E-12 ID:SGTC_2370|Compound:9071495|FD-Score:3.59|P-value:1.02E-4 ID:SGTC_2476|Compound:5806916|FD-Score:5.03|P-value:9.90E-8 ID:SGTC_2483|Compound:5729050|FD-Score:5.64|P-value:2.64E-9 ID:SGTC_2485|Compound:5633444|FD-Score:-3.06|P-value:7.52E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.68|P-value:7.04E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:4.29|P-value:4.46E-6 ID:SGTC_2852|Compound:9023854|FD-Score:4.45|P-value:2.04E-6 ID:SGTC_2921|Compound:7974240|FD-Score:4.08|P-value:1.23E-5 ID:SGTC_3008|Compound:9078912|FD-Score:3.46|P-value:1.71E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.64|P-value:8.18E-5 ID:SGTC_3047|Compound:9092122|FD-Score:4.90|P-value:1.97E-7 ID:SGTC_3170|Compound:9103054|FD-Score:4.69|P-value:6.09E-7 ID:SGTC_3233|Compound:9132340|FD-Score:3.56|P-value:1.14E-4

Top fitness defect scores for YGR121W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 7.76 5.3 µM 4.65E-16 255 4.24E-15
2 SGTC_1544 7-methoxy-4-methylcoumarin 6.40 105.0 µM 1.69E-11 2 7.64E-11
3 SGTC_2483 5729050 5.64 27.2 µM 2.64E-9 7 8.51E-9
4 SGTC_2476 5806916 5.03 10.5 µM 9.90E-8 4 2.52E-7
5 SGTC_631 k072-0230 4.97 41.5 µM 1.34E-7 60S ribosome export 4 3.34E-7
6 SGTC_3047 9092122 4.90 49.5 µM 1.97E-7 4 4.78E-7
7 SGTC_1397 3532-0190 4.86 20.1 µM 2.51E-7 3 5.99E-7
8 SGTC_296 1222-0039 4.77 74.9 µM 3.98E-7 6 9.24E-7
9 SGTC_3170 9103054 4.69 49.5 µM 6.09E-7 60S ribosome export 7 1.37E-6
10 SGTC_2852 9023854 4.45 52.0 µM 2.04E-6 22 4.26E-6
11 SGTC_2730 imipramine 4.29 71.3 µM 4.46E-6 15 8.84E-6
12 SGTC_2083 5306046 4.22 65.9 µM 6.18E-6 22 1.20E-5
13 SGTC_2921 7974240 4.08 10.7 µM 1.23E-5 50 2.29E-5
14 SGTC_1831 st055328 4.05 12.0 µM 1.40E-5 heme biosynthesis & mitochondrial translocase 20 2.57E-5
15 SGTC_1045 1348-1485 3.96 165.0 µM 2.11E-5 31 3.78E-5
16 SGTC_2032 5185112 3.85 26.0 µM 3.40E-5 12 5.92E-5
17 SGTC_518 1021-0119 3.85 62.6 µM 3.42E-5 ERG2 49 5.93E-5
18 SGTC_1694 st024011 3.79 44.9 µM 4.44E-5 ERG2 46 7.58E-5
19 SGTC_2646 retinol 3.68 96.8 µM 7.04E-5 17 1.17E-4
20 SGTC_386 1509-0011 3.65 3.1 µM 7.89E-5 160 1.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.293 1.21E-67 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.284 3.03E-63 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.265 8.08E-55 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.255 6.27E-51 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.247 4.99E-48 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.243 2.01E-46 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.241 1.54E-45 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.241 1.86E-45 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.241 2.17E-45 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.241 2.16E-45 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.239 7.46E-45 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.231 5.09E-42 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.223 7.48E-39 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.221 1.77E-38 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.219 9.93E-38 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER