YGR122C-A_d

Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR122C-A / YGR122C-A

Click on Significant Values for Screen Details ID:SGTC_144|Compound:4161-2749|FD-Score:-2.78|P-value:6.78E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.69|P-value:1.57E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.78|P-value:8.61E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:2.85|P-value:6.74E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.13|P-value:1.55E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.03|P-value:2.42E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.09|P-value:1.84E-6 ID:SGTC_537|Compound:1334-0398|FD-Score:-3.12|P-value:1.64E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.19|P-value:1.22E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:4.49|P-value:1.89E-7 ID:SGTC_589|Compound:1227-0070|FD-Score:-3.65|P-value:1.41E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.48|P-value:3.26E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:-2.82|P-value:5.78E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.05|P-value:2.22E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:2.90|P-value:5.37E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.71|P-value:8.95E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.17|P-value:1.33E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:2.82|P-value:7.38E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.56|P-value:2.86E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:2.95|P-value:4.34E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.93|P-value:4.79E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.06|P-value:2.74E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:2.79|P-value:8.39E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.78|P-value:6.83E-4 ID:SGTC_1710|Compound:st031758|FD-Score:2.77|P-value:9.16E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.15|P-value:1.88E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.44|P-value:1.81E-7 ID:SGTC_1988|Compound:st071872|FD-Score:4.07|P-value:2.07E-6 ID:SGTC_2238|Compound:6671620|FD-Score:-3.73|P-value:9.26E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-4.45|P-value:1.68E-7 ID:SGTC_2448|Compound:5185112|FD-Score:3.11|P-value:2.27E-4 ID:SGTC_2623|Compound:humulene|FD-Score:2.79|P-value:8.20E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.47|P-value:3.37E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-2.82|P-value:5.97E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.07|P-value:2.09E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.05|P-value:1.71E-6 ID:SGTC_2854|Compound:9024559|FD-Score:3.88|P-value:5.85E-6 ID:SGTC_2855|Compound:9016525|FD-Score:-3.26|P-value:8.82E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.07|P-value:2.66E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-2.73|P-value:8.41E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-2.73|P-value:8.32E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.09|P-value:1.88E-6 ID:SGTC_3133|Compound:9127736|FD-Score:3.85|P-value:6.82E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.64|P-value:2.01E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-4.86|P-value:1.30E-8 ID:SGTC_3207|Compound:9114163|FD-Score:6.00|P-value:5.37E-12 ID:SGTC_3211|Compound:9128781|FD-Score:9.54|P-value:1.24E-27 ID:SGTC_3313|Compound:9133968|FD-Score:2.93|P-value:4.80E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.78|P-value:6.78E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.69|P-value:1.57E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.78|P-value:8.61E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:2.85|P-value:6.74E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.13|P-value:1.55E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.03|P-value:2.42E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.09|P-value:1.84E-6 ID:SGTC_537|Compound:1334-0398|FD-Score:-3.12|P-value:1.64E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.19|P-value:1.22E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:4.49|P-value:1.89E-7 ID:SGTC_589|Compound:1227-0070|FD-Score:-3.65|P-value:1.41E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.48|P-value:3.26E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:-2.82|P-value:5.78E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.05|P-value:2.22E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:2.90|P-value:5.37E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.71|P-value:8.95E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.17|P-value:1.33E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:2.82|P-value:7.38E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.56|P-value:2.86E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:2.95|P-value:4.34E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.93|P-value:4.79E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.06|P-value:2.74E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:2.79|P-value:8.39E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.78|P-value:6.83E-4 ID:SGTC_1710|Compound:st031758|FD-Score:2.77|P-value:9.16E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.15|P-value:1.88E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.44|P-value:1.81E-7 ID:SGTC_1988|Compound:st071872|FD-Score:4.07|P-value:2.07E-6 ID:SGTC_2238|Compound:6671620|FD-Score:-3.73|P-value:9.26E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-4.45|P-value:1.68E-7 ID:SGTC_2448|Compound:5185112|FD-Score:3.11|P-value:2.27E-4 ID:SGTC_2623|Compound:humulene|FD-Score:2.79|P-value:8.20E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.47|P-value:3.37E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-2.82|P-value:5.97E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.07|P-value:2.09E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.05|P-value:1.71E-6 ID:SGTC_2854|Compound:9024559|FD-Score:3.88|P-value:5.85E-6 ID:SGTC_2855|Compound:9016525|FD-Score:-3.26|P-value:8.82E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.07|P-value:2.66E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-2.73|P-value:8.41E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-2.73|P-value:8.32E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.09|P-value:1.88E-6 ID:SGTC_3133|Compound:9127736|FD-Score:3.85|P-value:6.82E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.64|P-value:2.01E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-4.86|P-value:1.30E-8 ID:SGTC_3207|Compound:9114163|FD-Score:6.00|P-value:5.37E-12 ID:SGTC_3211|Compound:9128781|FD-Score:9.54|P-value:1.24E-27 ID:SGTC_3313|Compound:9133968|FD-Score:2.93|P-value:4.80E-4

Top fitness defect scores for YGR122C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3211 9128781 9.54 49.5 µM 1.24E-27 8 7.09E-22
2 SGTC_3207 9114163 6.00 49.5 µM 5.37E-12 6 9.98E-10
3 SGTC_551 k048-0028 4.49 34.9 µM 1.89E-7 7 3.54E-6
4 SGTC_315 k915-0449 4.13 187.0 µM 1.55E-6 53 1.85E-5
5 SGTC_359 0081-0058 4.09 15.9 µM 1.84E-6 60S ribosome export 40 2.11E-5
6 SGTC_3083 9117465 4.09 49.5 µM 1.88E-6 17 2.15E-5
7 SGTC_1988 st071872 4.07 53.4 µM 2.07E-6 9 2.32E-5
8 SGTC_2854 9024559 3.88 71.4 µM 5.85E-6 24 5.25E-5
9 SGTC_3133 9127736 3.85 49.5 µM 6.82E-6 21 5.91E-5
10 SGTC_156 3474-0145 3.69 5.6 µM 1.57E-5 endomembrane recycling 61 1.14E-4
11 SGTC_3203 9113543 3.64 49.5 µM 2.01E-5 40 1.39E-4
12 SGTC_1121 fusaric acid 3.56 630.5 nM 2.86E-5 46 1.83E-4
13 SGTC_1714 st033236 3.15 13.6 µM 1.88E-4 56 8.08E-4
14 SGTC_2448 5185112 3.11 27.2 µM 2.27E-4 34 9.36E-4
15 SGTC_2896 9052656 3.07 71.4 µM 2.66E-4 endomembrane recycling 196 0.00106
16 SGTC_1391 3442-0225 3.06 151.0 µM 2.74E-4 43 0.00109
17 SGTC_1245 0418-0076 2.95 17.2 µM 4.34E-4 ERG2 74 0.00157
18 SGTC_1261 0712-0010 2.93 12.7 µM 4.79E-4 RNA processing & uracil transport 74 0.00169
19 SGTC_3313 9133968 2.93 57.0 µM 4.80E-4 40 0.00170
20 SGTC_943 3253-1379 2.90 105.0 µM 5.37E-4 71 0.00185

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.254 1.30E-50 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.220 7.75E-38 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.169 5.67E-23 YJL151C SNA3 hom Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles
0.168 1.40E-22 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.163 1.92E-21 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.150 2.47E-18 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.141 2.57E-16 YJR148W BAT2 hom Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
0.137 1.93E-15 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.135 4.59E-15 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.123 8.87E-13 YDR307W_p PMT7_p hom Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation
0.123 1.01E-12 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.121 1.61E-12 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.120 3.69E-12 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.119 4.68E-12 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.119 4.73E-12 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress