HIPHOP chemogenomics database
YGR122C-A_d 
Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGR122C-A deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.254 | 1.30E-50 | YER069W | ARG5,6 | hom | Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine |
| 0.220 | 7.75E-38 | YOL140W | ARG8 | hom | Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine |
| 0.169 | 5.67E-23 | YJL151C | SNA3 | hom | Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles |
| 0.168 | 1.40E-22 | YNL001W | DOM34 | hom | Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication |
| 0.163 | 1.92E-21 | YOL060C | MAM3 | hom | Protein required for normal mitochondrial morphology, has similarity to hemolysins |
| 0.150 | 2.47E-18 | YNL149C | PGA2 | het | Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect |
| 0.141 | 2.57E-16 | YJR148W | BAT2 | hom | Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase |
| 0.137 | 1.93E-15 | YDL121C_p | YDL121C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein |
| 0.135 | 4.59E-15 | YDR107C | TMN2 | hom | Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments |
| 0.123 | 8.87E-13 | YDR307W_p | PMT7_p | hom | Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation |
| 0.123 | 1.01E-12 | YBL001C | ECM15 | hom | Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis |
| 0.121 | 1.61E-12 | YBR265W | TSC10 | het | 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family |
| 0.120 | 3.69E-12 | YKR102W | FLO10 | hom | Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth |
| 0.119 | 4.68E-12 | YLR053C_p | YLR053C_p | hom | Putative protein of unknown function |
| 0.119 | 4.73E-12 | YKL151C | YKL151C | hom | NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress |