YGR122W

Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR122W / YGR122W

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.93|P-value:4.06E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:6.45|P-value:2.02E-8 ID:SGTC_57|Compound:miconazole|FD-Score:-4.17|P-value:2.05E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-13.90|P-value:1.84E-32 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.22|P-value:1.76E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.52|P-value:1.26E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.35|P-value:3.20E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:4.52|P-value:5.92E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:6.16|P-value:7.57E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:5.96|P-value:1.88E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:5.21|P-value:4.44E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:5.72|P-value:5.46E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:7.46|P-value:1.08E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.98|P-value:1.11E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.74|P-value:2.70E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:23.00|P-value:2.34E-85 ID:SGTC_278|Compound:4092-0821|FD-Score:4.80|P-value:2.17E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:6.54|P-value:1.30E-8 ID:SGTC_320|Compound:4092-0846|FD-Score:4.02|P-value:3.03E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:5.93|P-value:2.22E-7 ID:SGTC_345|Compound:1362-0200|FD-Score:6.35|P-value:3.20E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:7.62|P-value:4.26E-11 ID:SGTC_351|Compound:caspofungin|FD-Score:7.62|P-value:4.26E-11 ID:SGTC_352|Compound:k048-0007|FD-Score:5.17|P-value:5.28E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:7.53|P-value:7.04E-11 ID:SGTC_433|Compound:pimozide|FD-Score:-3.68|P-value:8.99E-4 ID:SGTC_447|Compound:ml7|FD-Score:5.98|P-value:1.79E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.89|P-value:2.94E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.04|P-value:8.71E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:4.66|P-value:3.55E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:11.90|P-value:1.56E-24 ID:SGTC_528|Compound:3492-0019|FD-Score:18.80|P-value:5.47E-58 ID:SGTC_529|Compound:4076-0302|FD-Score:3.86|P-value:4.96E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:4.57|P-value:4.84E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.80|P-value:2.13E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:13.60|P-value:3.70E-31 ID:SGTC_577|Compound:r071-0003|FD-Score:5.94|P-value:2.07E-7 ID:SGTC_608|Compound:k048-0125|FD-Score:4.03|P-value:2.94E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:6.13|P-value:8.88E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:5.02|P-value:9.45E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:4.45|P-value:7.39E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:5.27|P-value:3.56E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:6.96|P-value:1.55E-9 ID:SGTC_778|Compound:3456-2434|FD-Score:6.43|P-value:2.16E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:9.21|P-value:2.23E-15 ID:SGTC_805|Compound:3852-0218|FD-Score:3.93|P-value:3.98E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:8.79|P-value:3.66E-14 ID:SGTC_902|Compound:1120-0002|FD-Score:6.94|P-value:1.69E-9 ID:SGTC_932|Compound:2857-0803|FD-Score:5.08|P-value:7.54E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.09|P-value:2.43E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.03|P-value:9.00E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.55|P-value:1.15E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.24|P-value:5.33E-8 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.06|P-value:2.72E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:8.78|P-value:3.77E-14 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.75|P-value:6.93E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.28|P-value:1.33E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-4.32|P-value:1.24E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.79|P-value:6.50E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.97|P-value:1.84E-7 ID:SGTC_1310|Compound:1188-0297|FD-Score:8.50|P-value:2.25E-13 ID:SGTC_1311|Compound:1190-0148|FD-Score:5.14|P-value:5.90E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:23.10|P-value:1.46E-86 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.22|P-value:5.87E-8 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.84|P-value:5.32E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.56|P-value:1.08E-6 ID:SGTC_1687|Compound:st020778|FD-Score:7.69|P-value:2.94E-11 ID:SGTC_1694|Compound:st024011|FD-Score:3.70|P-value:8.10E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.74|P-value:4.83E-9 ID:SGTC_1718|Compound:roemerine|FD-Score:3.95|P-value:3.74E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.39|P-value:2.23E-6 ID:SGTC_1729|Compound:st035615|FD-Score:7.95|P-value:6.62E-12 ID:SGTC_1731|Compound:st035964|FD-Score:4.43|P-value:7.96E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.83|P-value:5.52E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.95|P-value:4.01E-4 ID:SGTC_1754|Compound:st042065|FD-Score:11.10|P-value:1.72E-21 ID:SGTC_1760|Compound:st045453|FD-Score:10.40|P-value:4.81E-19 ID:SGTC_1775|Compound:st081588|FD-Score:-3.72|P-value:8.01E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:19.60|P-value:7.56E-63 ID:SGTC_1789|Compound:tunicamycin|FD-Score:7.15|P-value:5.74E-10 ID:SGTC_1797|Compound:st048695|FD-Score:6.15|P-value:8.02E-8 ID:SGTC_1800|Compound:st050079|FD-Score:5.75|P-value:4.77E-7 ID:SGTC_1801|Compound:st050089|FD-Score:8.61|P-value:1.17E-13 ID:SGTC_1803|Compound:st050068|FD-Score:12.10|P-value:3.45E-25 ID:SGTC_1818|Compound:st052136|FD-Score:3.96|P-value:3.63E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.13|P-value:9.69E-8 ID:SGTC_1884|Compound:5633444|FD-Score:10.40|P-value:4.60E-19 ID:SGTC_1892|Compound:st058411|FD-Score:-4.15|P-value:2.16E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-4.35|P-value:1.13E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.90|P-value:1.48E-5 ID:SGTC_2038|Compound:4100038|FD-Score:5.23|P-value:4.22E-6 ID:SGTC_2054|Compound:5233173|FD-Score:3.66|P-value:9.11E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.65|P-value:9.39E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-5.39|P-value:2.39E-6 ID:SGTC_2183|Compound:6420625|FD-Score:5.66|P-value:7.00E-7 ID:SGTC_2210|Compound:7115885|FD-Score:3.64|P-value:9.48E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.42|P-value:8.33E-5 ID:SGTC_2257|Compound:7960413|FD-Score:4.70|P-value:3.15E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.36|P-value:9.97E-5 ID:SGTC_2436|Compound:5633522|FD-Score:4.15|P-value:2.01E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:6.13|P-value:8.84E-8 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.68|P-value:9.15E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.95|P-value:1.22E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:6.17|P-value:7.51E-8 ID:SGTC_2630|Compound:antimycin a|FD-Score:-6.42|P-value:2.59E-8 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.58|P-value:4.67E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.75|P-value:2.59E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.15|P-value:2.00E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.63|P-value:4.37E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.05|P-value:6.66E-15 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.84|P-value:1.87E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.78|P-value:2.33E-5 ID:SGTC_2784|Compound:7567673|FD-Score:4.41|P-value:8.50E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.99|P-value:3.31E-4 ID:SGTC_2790|Compound:5423970|FD-Score:6.85|P-value:2.72E-9 ID:SGTC_2816|Compound:7982706|FD-Score:10.90|P-value:9.23E-21 ID:SGTC_2880|Compound:9042983|FD-Score:4.01|P-value:3.16E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.03|P-value:2.96E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.06|P-value:2.69E-4 ID:SGTC_2991|Compound:9074669|FD-Score:7.64|P-value:3.86E-11 ID:SGTC_2993|Compound:9054257|FD-Score:6.09|P-value:1.07E-7 ID:SGTC_3018|Compound:9082602|FD-Score:4.13|P-value:2.16E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.89|P-value:9.34E-12 ID:SGTC_3110|Compound:9122132|FD-Score:4.90|P-value:1.46E-5 ID:SGTC_3152|Compound:9099253|FD-Score:5.95|P-value:1.99E-7 ID:SGTC_3153|Compound:9100258|FD-Score:3.77|P-value:6.45E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.76|P-value:6.63E-4 ID:SGTC_3296|Compound:9122258|FD-Score:4.53|P-value:5.62E-5 ID:SGTC_3308|Compound:9128332|FD-Score:5.11|P-value:6.70E-6 ID:SGTC_3350|Compound:9150499|FD-Score:4.44|P-value:7.75E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.93|P-value:4.06E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:6.45|P-value:2.02E-8 ID:SGTC_57|Compound:miconazole|FD-Score:-4.17|P-value:2.05E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-13.90|P-value:1.84E-32 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.22|P-value:1.76E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.52|P-value:1.26E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.35|P-value:3.20E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:4.52|P-value:5.92E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:6.16|P-value:7.57E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:5.96|P-value:1.88E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:5.21|P-value:4.44E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:5.72|P-value:5.46E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:7.46|P-value:1.08E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.98|P-value:1.11E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.74|P-value:2.70E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:23.00|P-value:2.34E-85 ID:SGTC_278|Compound:4092-0821|FD-Score:4.80|P-value:2.17E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:6.54|P-value:1.30E-8 ID:SGTC_320|Compound:4092-0846|FD-Score:4.02|P-value:3.03E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:5.93|P-value:2.22E-7 ID:SGTC_345|Compound:1362-0200|FD-Score:6.35|P-value:3.20E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:7.62|P-value:4.26E-11 ID:SGTC_351|Compound:caspofungin|FD-Score:7.62|P-value:4.26E-11 ID:SGTC_352|Compound:k048-0007|FD-Score:5.17|P-value:5.28E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:7.53|P-value:7.04E-11 ID:SGTC_433|Compound:pimozide|FD-Score:-3.68|P-value:8.99E-4 ID:SGTC_447|Compound:ml7|FD-Score:5.98|P-value:1.79E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.89|P-value:2.94E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.04|P-value:8.71E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:4.66|P-value:3.55E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:11.90|P-value:1.56E-24 ID:SGTC_528|Compound:3492-0019|FD-Score:18.80|P-value:5.47E-58 ID:SGTC_529|Compound:4076-0302|FD-Score:3.86|P-value:4.96E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:4.57|P-value:4.84E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.80|P-value:2.13E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:13.60|P-value:3.70E-31 ID:SGTC_577|Compound:r071-0003|FD-Score:5.94|P-value:2.07E-7 ID:SGTC_608|Compound:k048-0125|FD-Score:4.03|P-value:2.94E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:6.13|P-value:8.88E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:5.02|P-value:9.45E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:4.45|P-value:7.39E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:5.27|P-value:3.56E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:6.96|P-value:1.55E-9 ID:SGTC_778|Compound:3456-2434|FD-Score:6.43|P-value:2.16E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:9.21|P-value:2.23E-15 ID:SGTC_805|Compound:3852-0218|FD-Score:3.93|P-value:3.98E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:8.79|P-value:3.66E-14 ID:SGTC_902|Compound:1120-0002|FD-Score:6.94|P-value:1.69E-9 ID:SGTC_932|Compound:2857-0803|FD-Score:5.08|P-value:7.54E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.09|P-value:2.43E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.03|P-value:9.00E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.55|P-value:1.15E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.24|P-value:5.33E-8 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.06|P-value:2.72E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:8.78|P-value:3.77E-14 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.75|P-value:6.93E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.28|P-value:1.33E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-4.32|P-value:1.24E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.79|P-value:6.50E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.97|P-value:1.84E-7 ID:SGTC_1310|Compound:1188-0297|FD-Score:8.50|P-value:2.25E-13 ID:SGTC_1311|Compound:1190-0148|FD-Score:5.14|P-value:5.90E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:23.10|P-value:1.46E-86 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.22|P-value:5.87E-8 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.84|P-value:5.32E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.56|P-value:1.08E-6 ID:SGTC_1687|Compound:st020778|FD-Score:7.69|P-value:2.94E-11 ID:SGTC_1694|Compound:st024011|FD-Score:3.70|P-value:8.10E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.74|P-value:4.83E-9 ID:SGTC_1718|Compound:roemerine|FD-Score:3.95|P-value:3.74E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.39|P-value:2.23E-6 ID:SGTC_1729|Compound:st035615|FD-Score:7.95|P-value:6.62E-12 ID:SGTC_1731|Compound:st035964|FD-Score:4.43|P-value:7.96E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.83|P-value:5.52E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.95|P-value:4.01E-4 ID:SGTC_1754|Compound:st042065|FD-Score:11.10|P-value:1.72E-21 ID:SGTC_1760|Compound:st045453|FD-Score:10.40|P-value:4.81E-19 ID:SGTC_1775|Compound:st081588|FD-Score:-3.72|P-value:8.01E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:19.60|P-value:7.56E-63 ID:SGTC_1789|Compound:tunicamycin|FD-Score:7.15|P-value:5.74E-10 ID:SGTC_1797|Compound:st048695|FD-Score:6.15|P-value:8.02E-8 ID:SGTC_1800|Compound:st050079|FD-Score:5.75|P-value:4.77E-7 ID:SGTC_1801|Compound:st050089|FD-Score:8.61|P-value:1.17E-13 ID:SGTC_1803|Compound:st050068|FD-Score:12.10|P-value:3.45E-25 ID:SGTC_1818|Compound:st052136|FD-Score:3.96|P-value:3.63E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.13|P-value:9.69E-8 ID:SGTC_1884|Compound:5633444|FD-Score:10.40|P-value:4.60E-19 ID:SGTC_1892|Compound:st058411|FD-Score:-4.15|P-value:2.16E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-4.35|P-value:1.13E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.90|P-value:1.48E-5 ID:SGTC_2038|Compound:4100038|FD-Score:5.23|P-value:4.22E-6 ID:SGTC_2054|Compound:5233173|FD-Score:3.66|P-value:9.11E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.65|P-value:9.39E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-5.39|P-value:2.39E-6 ID:SGTC_2183|Compound:6420625|FD-Score:5.66|P-value:7.00E-7 ID:SGTC_2210|Compound:7115885|FD-Score:3.64|P-value:9.48E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.42|P-value:8.33E-5 ID:SGTC_2257|Compound:7960413|FD-Score:4.70|P-value:3.15E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.36|P-value:9.97E-5 ID:SGTC_2436|Compound:5633522|FD-Score:4.15|P-value:2.01E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:6.13|P-value:8.84E-8 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.68|P-value:9.15E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.95|P-value:1.22E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:6.17|P-value:7.51E-8 ID:SGTC_2630|Compound:antimycin a|FD-Score:-6.42|P-value:2.59E-8 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.58|P-value:4.67E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.75|P-value:2.59E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.15|P-value:2.00E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.63|P-value:4.37E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.05|P-value:6.66E-15 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.84|P-value:1.87E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.78|P-value:2.33E-5 ID:SGTC_2784|Compound:7567673|FD-Score:4.41|P-value:8.50E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.99|P-value:3.31E-4 ID:SGTC_2790|Compound:5423970|FD-Score:6.85|P-value:2.72E-9 ID:SGTC_2816|Compound:7982706|FD-Score:10.90|P-value:9.23E-21 ID:SGTC_2880|Compound:9042983|FD-Score:4.01|P-value:3.16E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.03|P-value:2.96E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.06|P-value:2.69E-4 ID:SGTC_2991|Compound:9074669|FD-Score:7.64|P-value:3.86E-11 ID:SGTC_2993|Compound:9054257|FD-Score:6.09|P-value:1.07E-7 ID:SGTC_3018|Compound:9082602|FD-Score:4.13|P-value:2.16E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.89|P-value:9.34E-12 ID:SGTC_3110|Compound:9122132|FD-Score:4.90|P-value:1.46E-5 ID:SGTC_3152|Compound:9099253|FD-Score:5.95|P-value:1.99E-7 ID:SGTC_3153|Compound:9100258|FD-Score:3.77|P-value:6.45E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.76|P-value:6.63E-4 ID:SGTC_3296|Compound:9122258|FD-Score:4.53|P-value:5.62E-5 ID:SGTC_3308|Compound:9128332|FD-Score:5.11|P-value:6.70E-6 ID:SGTC_3350|Compound:9150499|FD-Score:4.44|P-value:7.75E-5

Top fitness defect scores for YGR122W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1317 1273-0028 23.10 910.0 nM 1.46E-86 azole & statin 2 8.70E-119
2 SGTC_227 fluconazole 23.00 33.5 µM 2.34E-85 azole & statin 3 4.04E-117
3 SGTC_1788 fluconazole 19.60 20.0 µM 7.56E-63 azole & statin 4 5.07E-86
4 SGTC_528 3492-0019 18.80 172.0 µM 5.47E-58 calcium & mitochondrial duress 3 2.61E-79
5 SGTC_576 1073-0113 13.60 22.7 µM 3.70E-31 redox potentiating 1 2.86E-42
6 SGTC_1803 st050068 12.10 52.4 µM 3.45E-25 NEO1-PIK1 14 4.90E-34
7 SGTC_525 k781-2675 11.90 26.7 µM 1.56E-24 redox potentiating 2 3.93E-33
8 SGTC_1754 st042065 11.10 16.1 µM 1.72E-21 NEO1-PIK1 17 6.11E-29
9 SGTC_2816 7982706 10.90 58.4 µM 9.23E-21 azole & statin 2 6.20E-28
10 SGTC_1884 5633444 10.40 25.0 µM 4.60E-19 redox potentiating 11 1.35E-25
11 SGTC_1760 st045453 10.40 10.4 µM 4.81E-19 NEO1-PIK1 31 1.44E-25
12 SGTC_788 1182-0090 9.21 188.0 µM 2.23E-15 endomembrane recycling 17 1.60E-20
13 SGTC_2688 kanamycin b 9.05 96.7 µM 6.66E-15 calcium & mitochondrial duress 43 7.23E-20
14 SGTC_862 0452-0056 8.79 10.2 µM 3.66E-14 azole & statin 7 7.53E-19
15 SGTC_1084 voriconazole 8.78 435.0 nM 3.77E-14 azole & statin 2 7.86E-19
16 SGTC_1801 st050089 8.61 28.4 µM 1.17E-13 NEO1-PIK1 21 3.73E-18
17 SGTC_1310 1188-0297 8.50 994.0 nM 2.25E-13 azole & statin 2 9.14E-18
18 SGTC_1729 st035615 7.95 46.0 µM 6.62E-12 3 9.55E-16
19 SGTC_3037 9091026 7.89 49.5 µM 9.34E-12 NEO1-PIK1 16 1.53E-15
20 SGTC_1687 st020778 7.69 55.4 µM 2.94E-11 72 7.39E-15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.684 0 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.621 0 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.610 0 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.586 2.06E-308 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.565 5.20E-282 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.562 1.42E-277 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.499 2.21E-210 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.463 6.98E-178 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.421 1.87E-144 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.401 1.18E-129 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.395 1.55E-125 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.371 5.80E-110 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.346 9.43E-95 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.315 2.84E-78 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.312 8.36E-77 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family