HIPHOP chemogenomics database

YGR130C

Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR130C / YGR130C

Click on Significant Values for Screen Details

Top fitness defect scores for YGR130C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_108	0509-0257	6.14	621.1 µM	9.28E-9		12	4.20E-10
2	SGTC_196	k015-0023	5.85	18.1 µM	4.10E-8	PDR1	6	2.43E-9
3	SGTC_1708	st033234	5.66	31.8 µM	1.08E-7		1	7.60E-9
4	SGTC_197	4544-0043	5.13	41.6 µM	1.30E-6	endomembrane recycling	28	1.45E-7
5	SGTC_2826	7992541	4.80	19.5 µM	5.60E-6		7	8.11E-7
6	SGTC_858	0438-0351	4.52	2.8 µM	1.73E-5	copper-dependent oxidative stress	11	3.07E-6
7	SGTC_1712	st032288	4.34	53.4 µM	3.49E-5	calcium & mitochondrial duress	161	7.02E-6
8	SGTC_2021	4019055	4.30	173.0 µM	4.10E-5	endomembrane recycling	102	8.50E-6
9	SGTC_1518	st038567	4.28	90.8 µM	4.47E-5		9	9.41E-6
10	SGTC_1629	st005085	4.25	44.9 µM	5.06E-5	RPP1 & pyrimidine depletion	27	1.09E-5
11	SGTC_2062	5245942	4.02	200.0 µM	1.18E-4		17	2.97E-5
12	SGTC_1121	fusaric acid	3.95	630.5 nM	1.50E-4		34	3.92E-5
13	SGTC_1767	st044992	3.94	70.3 µM	1.53E-4		23	4.00E-5
14	SGTC_834	0312-0008	3.94	75.7 µM	1.53E-4	NEO1	37	4.02E-5
15	SGTC_3165	9101544	3.90	49.5 µM	1.76E-4		12	4.73E-5
16	SGTC_738	1315-0003	3.90	72.4 µM	1.80E-4		22	4.84E-5
17	SGTC_2856	9022925	3.83	19.5 µM	2.27E-4		21	6.37E-5
18	SGTC_955	1216-0110	3.82	33.0 µM	2.38E-4	sphingolipid biosynthesis & PDR1	70	6.74E-5
19	SGTC_3210	9128157	3.77	49.5 µM	2.80E-4		52	8.15E-5
20	SGTC_899	1083-0020	3.72	478.0 µM	3.27E-4		27	9.80E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.181	5.64E-26	YDR467C_d	YDR467C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.165	7.28E-22	YFL033C	RIM15	hom	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.159	1.67E-20	YHR205W	SCH9	hom	AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.149	3.69E-18	YDR466W	PKH3	hom	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.142	1.29E-16	YDR005C	MAF1	hom	Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.127	1.54E-13	YGL151W	NUT1	hom	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.118	6.87E-12	YPR149W	NCE102	hom	Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
0.118	8.35E-12	YKL051W	SFK1	hom	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.117	1.18E-11	YDR357C_p	CNL1_p	hom	Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.113	6.11E-11	YPR091C	NVJ2	hom	Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.104	1.70E-9	YGL203C	KEX1	hom	Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.102	3.24E-9	YGR014W	MSB2	hom	Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
0.100	6.03E-9	YDL019C	OSH2	hom	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.098	1.23E-8	YDL167C	NRP1	hom	Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
0.095	3.47E-8	YDR315C	IPK1	hom	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable