YGR131W / FHN1

Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR131W / FHN1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.22|P-value:1.70E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:3.78|P-value:1.14E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.53|P-value:2.64E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.07|P-value:3.20E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.21|P-value:1.97E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.74|P-value:1.34E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-4.03|P-value:3.71E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:-3.44|P-value:3.57E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.31|P-value:6.31E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.20|P-value:9.09E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.25|P-value:6.90E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.66|P-value:1.78E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.16|P-value:9.30E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.38|P-value:4.97E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.38|P-value:4.85E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-5.45|P-value:4.46E-8 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.31|P-value:5.70E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.93|P-value:7.51E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.34|P-value:5.63E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-4.39|P-value:7.94E-6 ID:SGTC_1935|Compound:st074532|FD-Score:-3.41|P-value:4.03E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.50|P-value:3.25E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-3.33|P-value:5.31E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.38|P-value:4.52E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.20|P-value:8.13E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.78|P-value:1.01E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.28|P-value:1.49E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.49|P-value:3.00E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.82|P-value:9.62E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.69|P-value:1.42E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.49|P-value:5.86E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.39|P-value:4.33E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.21|P-value:8.06E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.60|P-value:2.24E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.33|P-value:5.36E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-4.77|P-value:1.42E-6 ID:SGTC_2974|Compound:9094440|FD-Score:4.68|P-value:2.46E-6 ID:SGTC_3135|Compound:9127742|FD-Score:3.99|P-value:4.89E-5 ID:SGTC_3220|Compound:9131269|FD-Score:3.90|P-value:7.11E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.22|P-value:1.70E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:3.78|P-value:1.14E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.53|P-value:2.64E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.07|P-value:3.20E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.21|P-value:1.97E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.74|P-value:1.34E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-4.03|P-value:3.71E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:-3.44|P-value:3.57E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.31|P-value:6.31E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.20|P-value:9.09E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.25|P-value:6.90E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.66|P-value:1.78E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.16|P-value:9.30E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.38|P-value:4.97E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.38|P-value:4.85E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-5.45|P-value:4.46E-8 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.31|P-value:5.70E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.93|P-value:7.51E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.34|P-value:5.63E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-4.39|P-value:7.94E-6 ID:SGTC_1935|Compound:st074532|FD-Score:-3.41|P-value:4.03E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.50|P-value:3.25E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-3.33|P-value:5.31E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.38|P-value:4.52E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.20|P-value:8.13E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.78|P-value:1.01E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.28|P-value:1.49E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.49|P-value:3.00E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.82|P-value:9.62E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.69|P-value:1.42E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.49|P-value:5.86E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.39|P-value:4.33E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.21|P-value:8.06E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.60|P-value:2.24E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.33|P-value:5.36E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-4.77|P-value:1.42E-6 ID:SGTC_2974|Compound:9094440|FD-Score:4.68|P-value:2.46E-6 ID:SGTC_3135|Compound:9127742|FD-Score:3.99|P-value:4.89E-5 ID:SGTC_3220|Compound:9131269|FD-Score:3.90|P-value:7.11E-5

Top fitness defect scores for YGR131W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1551 6-bromo-3'-methylflavone 4.93 63.5 µM 7.51E-7 2 4.16E-7
2 SGTC_2974 9094440 4.68 9.7 µM 2.46E-6 ergosterol biosynthesis 31 1.44E-6
3 SGTC_2605 digitonin 4.49 300.0 nM 5.86E-6 13 3.56E-6
4 SGTC_2347 9049783 4.28 174.8 µM 1.49E-5 18 9.42E-6
5 SGTC_159 3970-0959 4.21 50.0 µM 1.97E-5 66 1.26E-5
6 SGTC_3135 9127742 3.99 49.5 µM 4.89E-5 20 3.26E-5
7 SGTC_3220 9131269 3.90 49.5 µM 7.11E-5 11 4.82E-5
8 SGTC_2434 5670830 3.82 169.9 µM 9.62E-5 31 6.61E-5
9 SGTC_127 0180-0333 3.78 59.1 µM 1.14E-4 mitochondrial response to ROS 53 7.92E-5
10 SGTC_457 grayanotoxin iii 3.74 135.0 µM 1.34E-4 82 9.32E-5
11 SGTC_1283 0922-0125 3.66 16.4 µM 1.78E-4 34 1.26E-4
12 SGTC_2954 9074818 3.60 52.7 µM 2.24E-4 48 1.60E-4
13 SGTC_1940 st075990 3.50 51.1 µM 3.25E-4 60S ribosome export 33 2.36E-4
14 SGTC_1537 2',6'-dihydroxyflavanone 3.38 78.0 µM 4.85E-4 41 3.58E-4
15 SGTC_1412 3909-8563 3.38 178.0 µM 4.97E-4 21 3.67E-4
16 SGTC_1575 cyproterone acetate 3.34 48.0 µM 5.63E-4 43 4.18E-4
17 SGTC_828 2074-0507 3.31 139.0 µM 6.31E-4 RPP1 & pyrimidine depletion 42 4.71E-4
18 SGTC_892 0929-0076 3.20 29.0 µM 9.09E-4 TRP & mitochondrial translation 78 6.90E-4
19 SGTC_2528 xanthyletin 3.13 44.8 µM 0.00115 47 8.83E-4
20 SGTC_1909 st060837 3.10 51.5 µM 0.00124 88 9.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.59E-12 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.097 1.63E-8 YOR333C_d YOR333C_d hom Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth
0.092 9.58E-8 YOR170W_d YOR170W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4
0.088 3.56E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.085 8.35E-7 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.084 9.52E-7 YGR154C GTO1 hom Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
0.083 1.59E-6 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
0.082 1.83E-6 YOR007C SGT2 hom Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.082 2.19E-6 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.081 2.36E-6 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.081 2.76E-6 YDR330W UBX5 hom UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
0.079 4.55E-6 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.078 5.53E-6 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.078 6.35E-6 YOR025W HST3 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.077 8.28E-6 YKR017C HEL1 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)