YGR139W_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR139W / YGR139W

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-7.70|P-value:1.67E-18 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.48|P-value:3.97E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:3.02|P-value:3.08E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.58|P-value:2.46E-5 ID:SGTC_448|Compound:monastrol|FD-Score:4.66|P-value:6.56E-8 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.76|P-value:1.13E-5 ID:SGTC_459|Compound:nigericin|FD-Score:3.15|P-value:1.82E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.48|P-value:4.03E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:2.75|P-value:9.24E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-2.78|P-value:8.56E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.44|P-value:2.53E-7 ID:SGTC_813|Compound:k007-0158|FD-Score:4.54|P-value:1.32E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.38|P-value:6.74E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.07|P-value:2.73E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.34|P-value:7.82E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:-2.90|P-value:5.31E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.22|P-value:1.40E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.29|P-value:9.59E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.50|P-value:3.69E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:2.75|P-value:9.21E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.00|P-value:3.36E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:2.80|P-value:7.50E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-2.85|P-value:6.62E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:2.77|P-value:8.29E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.31|P-value:8.63E-5 ID:SGTC_1621|Compound:st003705|FD-Score:2.94|P-value:4.25E-4 ID:SGTC_1682|Compound:st012968|FD-Score:2.79|P-value:7.72E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.09|P-value:1.79E-6 ID:SGTC_1733|Compound:st037357|FD-Score:2.76|P-value:8.85E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-3.26|P-value:1.17E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.99|P-value:3.03E-6 ID:SGTC_1944|Compound:st076371|FD-Score:-2.75|P-value:9.48E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.41|P-value:6.08E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.75|P-value:1.06E-5 ID:SGTC_2075|Compound:5212009|FD-Score:2.92|P-value:4.70E-4 ID:SGTC_2148|Compound:5546263|FD-Score:2.81|P-value:7.34E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:2.95|P-value:4.20E-4 ID:SGTC_2278|Compound:7948257|FD-Score:2.94|P-value:4.37E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.82|P-value:7.03E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.23|P-value:1.25E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.75|P-value:1.04E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.91|P-value:4.60E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:2.87|P-value:5.78E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.08|P-value:2.10E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.13|P-value:2.11E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.34|P-value:4.71E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.04|P-value:2.84E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-2.94|P-value:4.65E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.69|P-value:1.58E-5 ID:SGTC_3003|Compound:9075612|FD-Score:2.75|P-value:9.25E-4 ID:SGTC_3048|Compound:9093155|FD-Score:2.73|P-value:9.92E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.56|P-value:2.80E-5 ID:SGTC_3127|Compound:9126946|FD-Score:2.75|P-value:9.00E-4 ID:SGTC_3142|Compound:9086498|FD-Score:2.74|P-value:9.34E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.27|P-value:1.05E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.50|P-value:3.67E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-7.70|P-value:1.67E-18 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.48|P-value:3.97E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:3.02|P-value:3.08E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.58|P-value:2.46E-5 ID:SGTC_448|Compound:monastrol|FD-Score:4.66|P-value:6.56E-8 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.76|P-value:1.13E-5 ID:SGTC_459|Compound:nigericin|FD-Score:3.15|P-value:1.82E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.48|P-value:4.03E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:2.75|P-value:9.24E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-2.78|P-value:8.56E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.44|P-value:2.53E-7 ID:SGTC_813|Compound:k007-0158|FD-Score:4.54|P-value:1.32E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.38|P-value:6.74E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.07|P-value:2.73E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.34|P-value:7.82E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:-2.90|P-value:5.31E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.22|P-value:1.40E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.29|P-value:9.59E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.50|P-value:3.69E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:2.75|P-value:9.21E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.00|P-value:3.36E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:2.80|P-value:7.50E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-2.85|P-value:6.62E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:2.77|P-value:8.29E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.31|P-value:8.63E-5 ID:SGTC_1621|Compound:st003705|FD-Score:2.94|P-value:4.25E-4 ID:SGTC_1682|Compound:st012968|FD-Score:2.79|P-value:7.72E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.09|P-value:1.79E-6 ID:SGTC_1733|Compound:st037357|FD-Score:2.76|P-value:8.85E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-3.26|P-value:1.17E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.99|P-value:3.03E-6 ID:SGTC_1944|Compound:st076371|FD-Score:-2.75|P-value:9.48E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-3.41|P-value:6.08E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.75|P-value:1.06E-5 ID:SGTC_2075|Compound:5212009|FD-Score:2.92|P-value:4.70E-4 ID:SGTC_2148|Compound:5546263|FD-Score:2.81|P-value:7.34E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:2.95|P-value:4.20E-4 ID:SGTC_2278|Compound:7948257|FD-Score:2.94|P-value:4.37E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.82|P-value:7.03E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.23|P-value:1.25E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.75|P-value:1.04E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.91|P-value:4.60E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:2.87|P-value:5.78E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.08|P-value:2.10E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.13|P-value:2.11E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.34|P-value:4.71E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.04|P-value:2.84E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-2.94|P-value:4.65E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.69|P-value:1.58E-5 ID:SGTC_3003|Compound:9075612|FD-Score:2.75|P-value:9.25E-4 ID:SGTC_3048|Compound:9093155|FD-Score:2.73|P-value:9.92E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.56|P-value:2.80E-5 ID:SGTC_3127|Compound:9126946|FD-Score:2.75|P-value:9.00E-4 ID:SGTC_3142|Compound:9086498|FD-Score:2.74|P-value:9.34E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.27|P-value:1.05E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.50|P-value:3.67E-5

Top fitness defect scores for YGR139W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_448 monastrol 4.66 171.0 µM 6.56E-8 5 1.59E-6
2 SGTC_813 k007-0158 4.54 173.0 µM 1.32E-7 fatty acid desaturase (OLE1) 29 2.76E-6
3 SGTC_670 4204-0025 4.44 119.0 µM 2.53E-7 copper-dependent oxidative stress 22 4.60E-6
4 SGTC_1727 st034309 4.09 9.9 µM 1.79E-6 35 2.15E-5
5 SGTC_1876 myriocin 3.99 605.0 nM 3.03E-6 29 3.26E-5
6 SGTC_2496 diffractaic acid 3.91 79.8 µM 4.60E-6 21 4.53E-5
7 SGTC_2493 resveratrol 3.75 26.1 µM 1.04E-5 10 8.67E-5
8 SGTC_2067 5224629 3.75 34.1 µM 1.06E-5 30 8.78E-5
9 SGTC_424 splitomicin 3.58 100.0 mM 2.46E-5 27 1.70E-4
10 SGTC_3081 9117243 3.56 49.5 µM 2.80E-5 fatty acid desaturase (OLE1) 29 1.89E-4
11 SGTC_3291 9121177 3.50 71.4 µM 3.67E-5 22 2.34E-4
12 SGTC_1211 1056-0033 3.50 32.3 µM 3.69E-5 18 2.35E-4
13 SGTC_272 doxorubicin 3.48 8.1 µM 3.97E-5 anthracycline transcription coupled DNA repair 36 2.49E-4
14 SGTC_486 niguldipine 3.48 82.0 µM 4.03E-5 amide catabolism 27 2.52E-4
15 SGTC_1131 3454-3128 3.34 32.3 µM 7.82E-5 72 4.26E-4
16 SGTC_1562 morin hydrate 3.31 59.1 µM 8.63E-5 36 4.60E-4
17 SGTC_1208 2323-2347 3.29 50.3 µM 9.59E-5 26 5.00E-4
18 SGTC_3153 9100258 3.27 49.5 µM 1.05E-4 54 5.38E-4
19 SGTC_2444 5485484 3.23 36.4 µM 1.25E-4 62 6.17E-4
20 SGTC_459 nigericin 3.15 15.3 µM 1.82E-4 99 8.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.256 3.28E-51 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.247 1.15E-47 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.184 6.71E-27 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.142 1.77E-16 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.119 4.21E-12 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.118 6.65E-12 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.116 1.71E-11 YDR384C ATO3 hom Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
0.116 1.77E-11 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.116 1.78E-11 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.114 3.46E-11 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.112 7.37E-11 YAL005C SSA1 hom ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils
0.111 1.00E-10 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.104 1.71E-9 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.100 5.90E-9 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.098 1.43E-8 YOR193W PEX27 hom Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p