YGR143W / SKN1

Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR143W / SKN1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-5.21|P-value:9.02E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:3.40|P-value:9.89E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.50|P-value:6.73E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:6.15|P-value:1.02E-8 ID:SGTC_289|Compound:k017-0060|FD-Score:4.91|P-value:3.86E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:-5.02|P-value:2.13E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:4.74|P-value:7.79E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:4.71|P-value:8.67E-6 ID:SGTC_836|Compound:0330-0104|FD-Score:4.29|P-value:4.63E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:6.92|P-value:1.39E-10 ID:SGTC_1013|Compound:4112-3890|FD-Score:-4.19|P-value:6.09E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.49|P-value:6.94E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.01|P-value:1.27E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-4.09|P-value:8.86E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.62|P-value:4.95E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.58|P-value:5.10E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.37|P-value:9.93E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-5.09|P-value:1.56E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.38|P-value:9.80E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.17|P-value:6.58E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.52|P-value:6.79E-4 ID:SGTC_1835|Compound:st008666|FD-Score:7.76|P-value:7.23E-13 ID:SGTC_1836|Compound:st055642|FD-Score:3.42|P-value:9.09E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.45|P-value:2.52E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.03|P-value:1.19E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.63|P-value:4.72E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.52|P-value:1.69E-5 ID:SGTC_2383|Compound:9036125|FD-Score:-3.67|P-value:3.76E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-4.36|P-value:3.17E-5 ID:SGTC_2537|Compound:larixol|FD-Score:-3.82|P-value:2.31E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.20|P-value:9.46E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.59|P-value:1.44E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.82|P-value:2.55E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.70|P-value:3.71E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.05|P-value:1.13E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.07|P-value:9.54E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.66|P-value:9.94E-6 ID:SGTC_2859|Compound:9028643|FD-Score:4.30|P-value:4.39E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.49|P-value:7.43E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.83|P-value:2.46E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.64|P-value:4.55E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.26|P-value:5.26E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.44|P-value:8.54E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.54|P-value:1.77E-5 ID:SGTC_3204|Compound:9114183|FD-Score:4.08|P-value:1.01E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.59|P-value:5.39E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.21|P-value:9.02E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:3.40|P-value:9.89E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.50|P-value:6.73E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:6.15|P-value:1.02E-8 ID:SGTC_289|Compound:k017-0060|FD-Score:4.91|P-value:3.86E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:-5.02|P-value:2.13E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:4.74|P-value:7.79E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:4.71|P-value:8.67E-6 ID:SGTC_836|Compound:0330-0104|FD-Score:4.29|P-value:4.63E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:6.92|P-value:1.39E-10 ID:SGTC_1013|Compound:4112-3890|FD-Score:-4.19|P-value:6.09E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.49|P-value:6.94E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.01|P-value:1.27E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-4.09|P-value:8.86E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.62|P-value:4.95E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.58|P-value:5.10E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.37|P-value:9.93E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-5.09|P-value:1.56E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.38|P-value:9.80E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.17|P-value:6.58E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.52|P-value:6.79E-4 ID:SGTC_1835|Compound:st008666|FD-Score:7.76|P-value:7.23E-13 ID:SGTC_1836|Compound:st055642|FD-Score:3.42|P-value:9.09E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.45|P-value:2.52E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.03|P-value:1.19E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.63|P-value:4.72E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.52|P-value:1.69E-5 ID:SGTC_2383|Compound:9036125|FD-Score:-3.67|P-value:3.76E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-4.36|P-value:3.17E-5 ID:SGTC_2537|Compound:larixol|FD-Score:-3.82|P-value:2.31E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.20|P-value:9.46E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.59|P-value:1.44E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.82|P-value:2.55E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.70|P-value:3.71E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.05|P-value:1.13E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.07|P-value:9.54E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.66|P-value:9.94E-6 ID:SGTC_2859|Compound:9028643|FD-Score:4.30|P-value:4.39E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.49|P-value:7.43E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.83|P-value:2.46E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.64|P-value:4.55E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.26|P-value:5.26E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.44|P-value:8.54E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.54|P-value:1.77E-5 ID:SGTC_3204|Compound:9114183|FD-Score:4.08|P-value:1.01E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.59|P-value:5.39E-4

Top fitness defect scores for YGR143W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1835 st008666 7.76 49.2 µM 7.23E-13 5 4.27E-15
2 SGTC_955 1216-0110 6.92 33.0 µM 1.39E-10 sphingolipid biosynthesis & PDR1 26 2.29E-12
3 SGTC_266 formosanin C 6.15 406.0 nM 1.02E-8 sphingolipid biosynthesis & PDR1 24 3.88E-10
4 SGTC_289 k017-0060 4.91 526.0 µM 3.86E-6 2 4.63E-7
5 SGTC_439 amiodarone 4.74 34.4 µM 7.79E-6 NEO1-PIK1 68 1.07E-6
6 SGTC_628 1636-0253 4.71 16.0 µM 8.67E-6 sphingolipid biosynthesis & PDR1 21 1.21E-6
7 SGTC_2581 avocatin a 4.59 64.0 µM 1.44E-5 sphingolipid biosynthesis & PDR1 40 2.22E-6
8 SGTC_3203 9113543 4.54 49.5 µM 1.77E-5 19 2.84E-6
9 SGTC_1920 st075728 4.45 45.7 µM 2.52E-5 11 4.32E-6
10 SGTC_2859 9028643 4.30 45.5 µM 4.39E-5 9 8.37E-6
11 SGTC_836 0330-0104 4.29 1.4 µM 4.63E-5 9 8.92E-6
12 SGTC_2954 9074818 4.26 52.7 µM 5.26E-5 31 1.04E-5
13 SGTC_3204 9114183 4.08 49.5 µM 1.01E-4 27 2.27E-5
14 SGTC_2710 st078562 4.05 53.7 µM 1.13E-4 15 2.58E-5
15 SGTC_1934 st074720 4.03 32.6 µM 1.19E-4 50 2.73E-5
16 SGTC_1055 3448-0672 4.01 86.0 µM 1.27E-4 29 2.98E-5
17 SGTC_2916 7875993 3.83 68.8 µM 2.46E-4 34 6.53E-5
18 SGTC_2658 polymyxin b sulfate 3.82 77.0 µM 2.55E-4 NEO1 43 6.80E-5
19 SGTC_2701 st077767 3.70 14.7 µM 3.71E-4 53 1.06E-4
20 SGTC_2933 9026794 3.64 32.5 µM 4.55E-4 32 1.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.297 3.95E-69 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.219 7.35E-38 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.218 1.86E-37 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.194 9.79E-30 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.158 4.27E-20 YBR036C CSG2 hom Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
0.155 1.32E-19 YGL253W HXK2 hom Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication
0.155 1.38E-19 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.143 6.76E-17 YKL020C SPT23 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.138 7.88E-16 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.133 1.11E-14 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.132 1.49E-14 YIL103W DPH1 hom Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p
0.131 2.56E-14 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
0.130 4.20E-14 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.129 5.32E-14 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.124 5.89E-13 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress