HIPHOP chemogenomics database

YGR146C / ECL1

Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR146C / ECL1

Click on Significant Values for Screen Details

Top fitness defect scores for YGR146C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2597	laccaic acid a	7.97	100.0 µM	1.49E-15		2	8.13E-16
2	SGTC_2713	st079149	5.55	53.4 µM	2.00E-8		4	1.42E-8
3	SGTC_628	1636-0253	5.11	16.0 µM	2.20E-7	sphingolipid biosynthesis & PDR1	15	1.63E-7
4	SGTC_1051	3253-3903	4.86	78.0 µM	7.65E-7		5	5.78E-7
5	SGTC_196	k015-0023	4.81	18.1 µM	9.81E-7	PDR1	11	7.44E-7
6	SGTC_873	0591-4978	4.74	488.0 µM	1.37E-6		8	1.05E-6
7	SGTC_917	harmaline	4.73	728.1 nM	1.44E-6	ergosterol biosynthesis	12	1.10E-6
8	SGTC_1129	3453-1384	4.60	223.0 µM	2.68E-6		24	2.07E-6
9	SGTC_310	1273-0058	4.51	1.1 µM	4.12E-6	mitochondrial stress	209	3.21E-6
10	SGTC_3004	9076122	4.43	71.4 µM	5.94E-6		11	4.66E-6
11	SGTC_3252	9135871	4.31	49.5 µM	1.03E-5		7	8.18E-6
12	SGTC_567	1080-0542	4.30	68.4 µM	1.08E-5		11	8.53E-6
13	SGTC_2780	5215298	4.27	71.4 µM	1.21E-5		28	9.58E-6
14	SGTC_2064	5220758	4.22	200.0 µM	1.54E-5		26	1.23E-5
15	SGTC_1189	1431-2119	4.18	7.3 µM	1.80E-5		19	1.44E-5
16	SGTC_166	k072-0058	4.10	166.4 µM	2.62E-5	DNA intercalators	29	2.11E-5
17	SGTC_2420	aureobasidin a	3.98	50.0 nM	4.19E-5		44	3.40E-5
18	SGTC_270	tamoxifen	3.90	5.5 µM	5.94E-5	NEO1	30	4.85E-5
19	SGTC_108	0509-0257	3.85	621.1 µM	7.24E-5		56	5.93E-5
20	SGTC_96	0929-0093	3.78	37.3 µM	9.39E-5	calcium & mitochondrial duress	17	7.73E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.107	5.90E-10	YJR108W	ABM1	hom	Protein of unknown function, required for normal microtubule organization
0.105	9.91E-10	YJR088C	EMC2	hom	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.092	1.04E-7	YNR008W	LRO1	hom	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.088	3.66E-7	YGL194C	HOS2	hom	Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.084	9.91E-7	YKL137W	CMC1	hom	Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.082	1.79E-6	YDL174C	DLD1	hom	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.082	2.11E-6	YHR086W	NAM8	hom	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.081	2.61E-6	YKR056W	TRM2	hom	tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
0.081	2.71E-6	YLR196W	PWP1	het	Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.078	6.33E-6	YLR324W	PEX30	hom	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.078	6.34E-6	YEL060C	PRB1	hom	Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.078	6.84E-6	YGL225W	VRG4	het	Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
0.075	1.43E-5	YMR267W	PPA2	hom	Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
0.074	1.96E-5	YNL259C	ATX1	hom	Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.073	2.48E-5	YLR361C-A_p	YLR361C-A_p	hom	Putative protein of unknown function