YGR148C / RPL24B

Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR148C / RPL24B

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.51|P-value:4.24E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.70|P-value:2.23E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.59|P-value:4.07E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.96|P-value:1.31E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:3.88|P-value:1.14E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:6.71|P-value:1.12E-10 ID:SGTC_431|Compound:k089-0097|FD-Score:4.31|P-value:2.20E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:4.49|P-value:1.05E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.62|P-value:3.63E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.47|P-value:5.97E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.56|P-value:4.51E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-4.06|P-value:7.45E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:3.54|P-value:3.87E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:4.00|P-value:7.35E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:4.57|P-value:7.43E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.78|P-value:2.07E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.47|P-value:5.93E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.38|P-value:1.67E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:5.74|P-value:2.76E-8 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.02|P-value:8.64E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.32|P-value:9.62E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.29|P-value:2.41E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.24|P-value:2.87E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.36|P-value:7.13E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-4.02|P-value:8.61E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.54|P-value:4.79E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.93|P-value:9.45E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.67|P-value:2.50E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.62|P-value:3.59E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.72|P-value:2.10E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.27|P-value:9.31E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.45|P-value:6.52E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.30|P-value:8.58E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.59|P-value:4.07E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.95|P-value:9.00E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-4.07|P-value:7.25E-5 ID:SGTC_1945|Compound:st075991|FD-Score:3.73|P-value:1.96E-4 ID:SGTC_1947|Compound:st076332|FD-Score:4.76|P-value:3.25E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-5.26|P-value:4.17E-7 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.77|P-value:2.12E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-4.85|P-value:2.84E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.78|P-value:1.65E-4 ID:SGTC_2113|Compound:5491891|FD-Score:4.03|P-value:6.50E-5 ID:SGTC_2297|Compound:7971671|FD-Score:-4.92|P-value:2.05E-6 ID:SGTC_2299|Compound:7976368|FD-Score:-4.16|P-value:5.08E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.80|P-value:1.99E-8 ID:SGTC_2481|Compound:5478948|FD-Score:3.45|P-value:5.19E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.54|P-value:4.77E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.08|P-value:6.96E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.54|P-value:4.76E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.30|P-value:8.56E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.76|P-value:2.24E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.97|P-value:1.02E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.69|P-value:2.33E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-4.24|P-value:3.67E-5 ID:SGTC_3181|Compound:9108277|FD-Score:4.14|P-value:4.28E-5 ID:SGTC_3233|Compound:9132340|FD-Score:4.71|P-value:4.08E-6 ID:SGTC_26|Compound:0302-0163|FD-Score:3.51|P-value:4.24E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.70|P-value:2.23E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.59|P-value:4.07E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.96|P-value:1.31E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:3.88|P-value:1.14E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:6.71|P-value:1.12E-10 ID:SGTC_431|Compound:k089-0097|FD-Score:4.31|P-value:2.20E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:4.49|P-value:1.05E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.62|P-value:3.63E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.47|P-value:5.97E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.56|P-value:4.51E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-4.06|P-value:7.45E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:3.54|P-value:3.87E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:4.00|P-value:7.35E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:4.57|P-value:7.43E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.78|P-value:2.07E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.47|P-value:5.93E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.38|P-value:1.67E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:5.74|P-value:2.76E-8 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.02|P-value:8.64E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.32|P-value:9.62E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.29|P-value:2.41E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.24|P-value:2.87E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.36|P-value:7.13E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-4.02|P-value:8.61E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.54|P-value:4.79E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.93|P-value:9.45E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.67|P-value:2.50E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.62|P-value:3.59E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.72|P-value:2.10E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.27|P-value:9.31E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.45|P-value:6.52E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.30|P-value:8.58E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.59|P-value:4.07E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.95|P-value:9.00E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-4.07|P-value:7.25E-5 ID:SGTC_1945|Compound:st075991|FD-Score:3.73|P-value:1.96E-4 ID:SGTC_1947|Compound:st076332|FD-Score:4.76|P-value:3.25E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-5.26|P-value:4.17E-7 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.77|P-value:2.12E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-4.85|P-value:2.84E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.78|P-value:1.65E-4 ID:SGTC_2113|Compound:5491891|FD-Score:4.03|P-value:6.50E-5 ID:SGTC_2297|Compound:7971671|FD-Score:-4.92|P-value:2.05E-6 ID:SGTC_2299|Compound:7976368|FD-Score:-4.16|P-value:5.08E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.80|P-value:1.99E-8 ID:SGTC_2481|Compound:5478948|FD-Score:3.45|P-value:5.19E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.54|P-value:4.77E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.08|P-value:6.96E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.54|P-value:4.76E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.30|P-value:8.56E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.76|P-value:2.24E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.97|P-value:1.02E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.69|P-value:2.33E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-4.24|P-value:3.67E-5 ID:SGTC_3181|Compound:9108277|FD-Score:4.14|P-value:4.28E-5 ID:SGTC_3233|Compound:9132340|FD-Score:4.71|P-value:4.08E-6

Top fitness defect scores for YGR148C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_359 0081-0058 6.71 15.9 µM 1.12E-10 60S ribosome export 8 9.88E-12
2 SGTC_2406 ethylparaben 5.80 405.7 µM 1.99E-8 12 3.26E-9
3 SGTC_920 mycophenolic acid 5.74 780.4 nM 2.76E-8 3 4.71E-9
4 SGTC_183 3914-0051 4.96 30.6 µM 1.31E-6 60S ribosome export 6 3.52E-7
5 SGTC_1947 st076332 4.76 61.6 µM 3.25E-6 7 9.72E-7
6 SGTC_3233 9132340 4.71 49.5 µM 4.08E-6 9 1.25E-6
7 SGTC_706 4262-0057 4.57 46.9 µM 7.43E-6 fatty acid desaturase (OLE1) 16 2.45E-6
8 SGTC_579 4491-1009 4.49 110.0 µM 1.05E-5 60S ribosome export 13 3.59E-6
9 SGTC_887 0885-0007 4.38 9.6 µM 1.67E-5 endomembrane recycling 29 6.05E-6
10 SGTC_431 k089-0097 4.31 107.0 µM 2.20E-5 iron homeostasis 27 8.19E-6
11 SGTC_964 1287-0107 4.29 19.4 µM 2.41E-5 cell wall 30 9.08E-6
12 SGTC_1030 k029-0042 4.24 36.7 µM 2.87E-5 TSC3-RPN4 18 1.10E-5
13 SGTC_3181 9108277 4.14 49.5 µM 4.28E-5 iron homeostasis 12 1.72E-5
14 SGTC_2113 5491891 4.03 107.0 µM 6.50E-5 TSC3-RPN4 17 2.74E-5
15 SGTC_699 0375-0592 4.00 111.0 µM 7.35E-5 iron homeostasis 16 3.15E-5
16 SGTC_1908 st060353 3.95 56.5 µM 9.00E-5 RPP1 & pyrimidine depletion 35 3.95E-5
17 SGTC_1130 3454-2858 3.93 15.9 µM 9.45E-5 NEO1 90 4.17E-5
18 SGTC_258 haloperidol 3.88 50.8 µM 1.14E-4 fatty acid desaturase (OLE1) 32 5.14E-5
19 SGTC_2042 p-Dimethylaminoacetophenone 3.78 200.0 µM 1.65E-4 22 7.76E-5
20 SGTC_1945 st075991 3.73 56.6 µM 1.96E-4 60S ribosome export 25 9.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 3.06E-13 YHR170W NMD3 het Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
0.120 2.79E-12 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.106 7.39E-10 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.097 1.87E-8 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.095 4.07E-8 YLR357W RSC2 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
0.090 1.64E-7 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.090 1.86E-7 YBL035C POL12 het B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
0.088 3.10E-7 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.082 2.09E-6 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.081 2.35E-6 YOR341W RPA190 het RNA polymerase I largest subunit A190
0.081 2.59E-6 YGL108C YGL108C hom Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress
0.081 2.82E-6 YDL184C RPL41A hom Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
0.080 3.09E-6 YIL038C NOT3 hom Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
0.079 4.09E-6 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.078 6.04E-6 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication