YGR149W_p

Putative protein of unknown function; predicted to be an integal membrane protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR149W / YGR149W

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:2.96|P-value:5.35E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.27|P-value:2.82E-9 ID:SGTC_443|Compound:clozapine|FD-Score:3.12|P-value:2.84E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-2.87|P-value:7.44E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.77|P-value:1.59E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:2.81|P-value:9.67E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.18|P-value:2.24E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.75|P-value:1.69E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-2.83|P-value:8.73E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-2.97|P-value:5.12E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.75|P-value:1.67E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:2.80|P-value:9.76E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.67|P-value:2.52E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.24|P-value:1.42E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.40|P-value:8.64E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.65|P-value:2.19E-10 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.04|P-value:3.85E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-4.37|P-value:6.83E-7 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-2.88|P-value:7.23E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.09|P-value:3.19E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:2.86|P-value:8.03E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:5.28|P-value:2.71E-9 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-2.87|P-value:7.51E-4 ID:SGTC_1742|Compound:st038235|FD-Score:2.84|P-value:8.59E-4 ID:SGTC_2013|Compound:4024628|FD-Score:6.53|P-value:2.79E-13 ID:SGTC_2014|Compound:4013930|FD-Score:3.87|P-value:9.42E-6 ID:SGTC_2021|Compound:4019055|FD-Score:5.45|P-value:8.39E-10 ID:SGTC_2292|Compound:7671323|FD-Score:3.19|P-value:2.11E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.33|P-value:1.19E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:2.92|P-value:6.27E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:2.86|P-value:7.87E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.08|P-value:3.27E-6 ID:SGTC_2796|Compound:7949634|FD-Score:-2.84|P-value:8.59E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-2.91|P-value:6.44E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.73|P-value:1.88E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.04|P-value:3.92E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.75|P-value:1.67E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-3.41|P-value:8.28E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-2.80|P-value:9.68E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.32|P-value:1.22E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.63|P-value:3.08E-5 ID:SGTC_3354|Compound:9151612|FD-Score:2.91|P-value:6.40E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:2.96|P-value:5.35E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.27|P-value:2.82E-9 ID:SGTC_443|Compound:clozapine|FD-Score:3.12|P-value:2.84E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-2.87|P-value:7.44E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.77|P-value:1.59E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:2.81|P-value:9.67E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.18|P-value:2.24E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.75|P-value:1.69E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-2.83|P-value:8.73E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-2.97|P-value:5.12E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.75|P-value:1.67E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:2.80|P-value:9.76E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.67|P-value:2.52E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.24|P-value:1.42E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.40|P-value:8.64E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.65|P-value:2.19E-10 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.04|P-value:3.85E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-4.37|P-value:6.83E-7 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-2.88|P-value:7.23E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.09|P-value:3.19E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:2.86|P-value:8.03E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:5.28|P-value:2.71E-9 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-2.87|P-value:7.51E-4 ID:SGTC_1742|Compound:st038235|FD-Score:2.84|P-value:8.59E-4 ID:SGTC_2013|Compound:4024628|FD-Score:6.53|P-value:2.79E-13 ID:SGTC_2014|Compound:4013930|FD-Score:3.87|P-value:9.42E-6 ID:SGTC_2021|Compound:4019055|FD-Score:5.45|P-value:8.39E-10 ID:SGTC_2292|Compound:7671323|FD-Score:3.19|P-value:2.11E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.33|P-value:1.19E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:2.92|P-value:6.27E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:2.86|P-value:7.87E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.08|P-value:3.27E-6 ID:SGTC_2796|Compound:7949634|FD-Score:-2.84|P-value:8.59E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-2.91|P-value:6.44E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.73|P-value:1.88E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.04|P-value:3.92E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.75|P-value:1.67E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-3.41|P-value:8.28E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-2.80|P-value:9.68E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.32|P-value:1.22E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.63|P-value:3.08E-5 ID:SGTC_3354|Compound:9151612|FD-Score:2.91|P-value:6.40E-4

Top fitness defect scores for YGR149W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2013 4024628 6.53 200.0 µM 2.79E-13 12 3.39E-11
2 SGTC_2021 4019055 5.45 173.0 µM 8.39E-10 endomembrane recycling 55 2.47E-8
3 SGTC_1380 2291-0730 5.28 164.0 µM 2.71E-9 5 6.46E-8
4 SGTC_310 1273-0058 5.27 1.1 µM 2.82E-9 mitochondrial stress 171 6.69E-8
5 SGTC_1039 k821-0043 4.24 94.0 µM 1.42E-6 Golgi 19 1.13E-5
6 SGTC_2693 st077581 4.08 40.7 µM 3.27E-6 32 2.25E-5
7 SGTC_2014 4013930 3.87 200.0 µM 9.42E-6 34 5.40E-5
8 SGTC_553 k007-0256 3.77 45.7 µM 1.59E-5 heme biosynthesis & mitochondrial translocase 21 8.31E-5
9 SGTC_2839 9003951 3.73 26.0 µM 1.88E-5 13 9.55E-5
10 SGTC_1040 k898-0338 3.40 155.0 µM 8.64E-5 36 3.38E-4
11 SGTC_2300 7976697 3.33 71.6 µM 1.19E-4 ERG2 55 4.41E-4
12 SGTC_2292 7671323 3.19 168.1 µM 2.11E-4 RNA processing & uracil transport 77 7.10E-4
13 SGTC_443 clozapine 3.12 122.0 µM 2.84E-4 NEO1-PIK1 22 9.07E-4
14 SGTC_1270 0831-1170 3.09 17.3 µM 3.19E-4 41 9.97E-4
15 SGTC_1114 scopoletin 3.04 1.7 µM 3.85E-4 43 0.00117
16 SGTC_2848 9016370 3.04 26.0 µM 3.92E-4 70 0.00118
17 SGTC_143 4032-1194 2.96 15.7 µM 5.35E-4 142 0.00153
18 SGTC_2419 paclitaxel 2.92 166.5 µM 6.27E-4 119 0.00175
19 SGTC_3354 9151612 2.91 71.4 µM 6.40E-4 56 0.00178
20 SGTC_2616 abietic acid 2.86 100.0 µM 7.87E-4 73 0.00211

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 5.52E-33 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.203 1.21E-32 YLR413W_p YLR413W_p hom Putative protein of unknown function; YLR413W is not an essential gene
0.198 7.53E-31 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.195 4.02E-30 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.195 4.29E-30 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.193 1.44E-29 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.193 1.78E-29 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.191 5.84E-29 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.189 1.73E-28 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.188 4.30E-28 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.187 7.13E-28 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.181 4.45E-26 YDR037W KRS1 het Lysyl-tRNA synthetase
0.177 3.94E-25 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.175 2.00E-24 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.173 6.20E-24 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function