HIPHOP chemogenomics database

YGR150C / CCM1

Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR150C / CCM1

Click on Significant Values for Screen Details

Top fitness defect scores for YGR150C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	16.70	5.3 µM	4.14E-52		81	3.33E-63
2	SGTC_1635	st007035	16.30	42.4 µM	3.05E-49		31	1.06E-59
3	SGTC_134	0269-0018	14.00	6.9 µM	3.56E-37		22	5.86E-45
4	SGTC_386	1509-0011	11.30	3.1 µM	4.75E-25		38	3.73E-30
5	SGTC_275	trichlorophene	10.20	5.7 µM	1.44E-20	mitochondrial stress	44	1.09E-24
6	SGTC_1625	st003711	9.43	30.1 µM	7.10E-18	calcium & mitochondrial duress	2	2.11E-21
7	SGTC_173	1273-0061	8.47	2.7 µM	8.91E-15	mitochondrial stress	58	1.26E-17
8	SGTC_1742	st038235	7.38	28.9 µM	1.21E-11	mitochondrial stress	23	8.19E-14
9	SGTC_1188	1403-0014	7.26	4.6 µM	2.41E-11	mitochondrial stress	9	1.91E-13
10	SGTC_365	0121-0052	7.01	13.6 µM	1.10E-10	mitochondrial response to ROS	11	1.21E-12
11	SGTC_1478	0453-0656	6.98	35.7 µM	1.30E-10		2	1.49E-12
12	SGTC_87	0100-0052	6.24	35.5 µM	7.74E-9		28	2.13E-10
13	SGTC_310	1273-0058	5.73	1.1 µM	1.05E-7	mitochondrial stress	151	5.03E-9
14	SGTC_745	0469-0705	5.68	296.0 µM	1.31E-7	mitochondrial processes	4	6.64E-9
15	SGTC_1629	st005085	5.61	44.9 µM	1.87E-7	RPP1 & pyrimidine depletion	9	1.02E-8
16	SGTC_1069	diphenylcyclopropenone	5.36	8.5 µM	5.95E-7		12	4.15E-8
17	SGTC_908	3448-7491	5.23	47.7 µM	1.08E-6	mitochondrial stress	70	8.57E-8
18	SGTC_1627	st003713	4.80	25.6 µM	6.69E-6	calcium & mitochondrial duress	44	7.79E-7
19	SGTC_1085	doxorubicin	4.65	7.7 µM	1.27E-5	anthracycline transcription coupled DNA repair	8	1.70E-6
20	SGTC_2165	5727197	4.55	32.1 µM	1.84E-5		24	2.65E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.569	6.61E-287	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.565	2.93E-282	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.559	2.31E-274	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.555	1.00E-269	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.550	1.61E-263	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.549	3.10E-263	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.546	2.53E-259	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.535	3.58E-247	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.533	3.17E-245	YKL155C	RSM22	hom	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.528	5.17E-240	YDR231C	COX20	hom	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.525	7.54E-237	YKL194C	MST1	hom	Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.525	2.92E-236	YPL132W	COX11	hom	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.522	8.10E-234	YNR045W	PET494	hom	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.521	6.57E-233	YML129C	COX14	hom	Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.521	6.14E-232	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases