YGR152C / RSR1

GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR152C / RSR1

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.13|P-value:8.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.78|P-value:8.17E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.37|P-value:3.85E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.21|P-value:6.76E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.12|P-value:9.20E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.13|P-value:8.37E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.25|P-value:5.61E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.16|P-value:7.70E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.59|P-value:1.64E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.21|P-value:6.35E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.68|P-value:1.19E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.47|P-value:2.49E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.84|P-value:5.92E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.84|P-value:2.52E-9 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.46|P-value:2.61E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.19|P-value:6.92E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.32|P-value:4.41E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.56|P-value:1.83E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-4.15|P-value:1.70E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.69|P-value:1.09E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.94|P-value:4.01E-5 ID:SGTC_2296|Compound:7971656|FD-Score:3.43|P-value:2.90E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.51|P-value:2.18E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.76|P-value:8.24E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-4.32|P-value:7.98E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.79|P-value:7.81E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.09|P-value:2.27E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.95|P-value:3.72E-5 ID:SGTC_2818|Compound:7996756|FD-Score:-3.54|P-value:2.09E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-5.51|P-value:1.94E-8 ID:SGTC_2998|Compound:9066762|FD-Score:4.58|P-value:2.25E-6 ID:SGTC_3077|Compound:9117319|FD-Score:-5.39|P-value:3.67E-8 ID:SGTC_3283|Compound:9109332|FD-Score:4.57|P-value:2.41E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-4.24|P-value:1.15E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-3.94|P-value:4.22E-5 ID:SGTC_3339|Compound:9145883|FD-Score:3.33|P-value:4.27E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.13|P-value:8.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.78|P-value:8.17E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.37|P-value:3.85E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.21|P-value:6.76E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.12|P-value:9.20E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.13|P-value:8.37E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.25|P-value:5.61E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.16|P-value:7.70E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.59|P-value:1.64E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.21|P-value:6.35E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.68|P-value:1.19E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.47|P-value:2.49E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.84|P-value:5.92E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.84|P-value:2.52E-9 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.46|P-value:2.61E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.19|P-value:6.92E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.32|P-value:4.41E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.56|P-value:1.83E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-4.15|P-value:1.70E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.69|P-value:1.09E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.94|P-value:4.01E-5 ID:SGTC_2296|Compound:7971656|FD-Score:3.43|P-value:2.90E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.51|P-value:2.18E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.76|P-value:8.24E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-4.32|P-value:7.98E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.79|P-value:7.81E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.09|P-value:2.27E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.95|P-value:3.72E-5 ID:SGTC_2818|Compound:7996756|FD-Score:-3.54|P-value:2.09E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-5.51|P-value:1.94E-8 ID:SGTC_2998|Compound:9066762|FD-Score:4.58|P-value:2.25E-6 ID:SGTC_3077|Compound:9117319|FD-Score:-5.39|P-value:3.67E-8 ID:SGTC_3283|Compound:9109332|FD-Score:4.57|P-value:2.41E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-4.24|P-value:1.15E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-3.94|P-value:4.22E-5 ID:SGTC_3339|Compound:9145883|FD-Score:3.33|P-value:4.27E-4

Top fitness defect scores for YGR152C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1003 4049-0218 5.84 100.0 µM 2.52E-9 3 2.63E-9
2 SGTC_2998 9066762 4.58 71.4 µM 2.25E-6 RPP1 & pyrimidine depletion 14 2.33E-6
3 SGTC_3283 9109332 4.57 35.8 µM 2.41E-6 DNA intercalators 7 2.50E-6
4 SGTC_2691 st077356 3.95 60.2 µM 3.72E-5 28 3.84E-5
5 SGTC_2163 5671233 3.94 125.0 µM 4.01E-5 25 4.14E-5
6 SGTC_967 1306-0166 3.84 352.0 µM 5.92E-5 41 6.11E-5
7 SGTC_2347 9049783 3.76 174.8 µM 8.24E-5 38 8.50E-5
8 SGTC_2010 4012422 3.69 159.0 µM 1.09E-4 30 1.13E-4
9 SGTC_844 0330-0132 3.59 15.3 µM 1.64E-4 25 1.69E-4
10 SGTC_1718 roemerine 3.56 11.9 µM 1.83E-4 redox potentiating 75 1.88E-4
11 SGTC_2327 6189656 3.51 200.0 µM 2.18E-4 31 2.24E-4
12 SGTC_941 3237-0776 3.47 460.0 µM 2.49E-4 32 2.56E-4
13 SGTC_1004 4084-0029 3.46 199.0 µM 2.61E-4 29 2.68E-4
14 SGTC_2296 7971656 3.43 126.5 µM 2.90E-4 65 2.99E-4
15 SGTC_3339 9145883 3.33 14.9 µM 4.27E-4 30 4.39E-4
16 SGTC_1626 st003712 3.32 1.8 µM 4.41E-4 46 4.54E-4
17 SGTC_669 0108-0021 3.25 26.2 µM 5.61E-4 fatty acid desaturase (OLE1) 133 5.77E-4
18 SGTC_855 0428-0020 3.21 25.0 µM 6.35E-4 Golgi 47 6.53E-4
19 SGTC_1605 st000082 3.19 49.1 µM 6.92E-4 60S ribosome export 50 7.11E-4
20 SGTC_753 1322-0200 3.16 289.0 µM 7.70E-4 55 7.91E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.58E-11 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.111 1.39E-10 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.111 1.28E-10 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.107 5.10E-10 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.81E-9 YOL153C YOL153C hom Hypothetical protein
0.102 3.93E-9 YOR296W_p YOR296W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.100 6.92E-9 YGR141W VPS62 hom Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
0.098 1.13E-8 YBR249C ARO4 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
0.097 1.64E-8 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.096 2.33E-8 YIL059C_d YIL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
0.091 1.23E-7 YDR209C_d YDR209C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
0.090 1.64E-7 YPL147W PXA1 hom Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.090 1.79E-7 YDR261C EXG2 hom Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.089 2.50E-7 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.088 3.55E-7 YHR127W YHR127W hom Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis