HIPHOP chemogenomics database
YGR152C / RSR1 
GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YGR152C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.116 | 1.58E-11 | YHR042W | NCP1 | het | NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p |
| 0.111 | 1.39E-10 | YDR371W_p | CTS2_p | hom | Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect |
| 0.111 | 1.28E-10 | YPL190C | NAB3 | het | RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing |
| 0.107 | 5.10E-10 | YPR126C_d | YPR126C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.102 | 3.81E-9 | YOL153C | YOL153C | hom | Hypothetical protein |
| 0.102 | 3.93E-9 | YOR296W_p | YOR296W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene |
| 0.100 | 6.92E-9 | YGR141W | VPS62 | hom | Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins |
| 0.098 | 1.13E-8 | YBR249C | ARO4 | hom | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress |
| 0.097 | 1.64E-8 | YDL133C-A | RPL41B | hom | Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication |
| 0.096 | 2.33E-8 | YIL059C_d | YIL059C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W |
| 0.091 | 1.23E-7 | YDR209C_d | YDR209C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. |
| 0.090 | 1.64E-7 | YPL147W | PXA1 | hom | Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder |
| 0.090 | 1.79E-7 | YDR261C | EXG2 | hom | Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor |
| 0.089 | 2.50E-7 | YDR124W_p | YDR124W_p | hom | Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor |
| 0.088 | 3.55E-7 | YHR127W | YHR127W | hom | Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis |