YGR159C / NSR1

Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR159C / NSR1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.96|P-value:1.35E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.72|P-value:3.58E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.37|P-value:9.56E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-5.08|P-value:1.90E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-7.00|P-value:9.12E-11 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.71|P-value:9.19E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.60|P-value:2.21E-15 ID:SGTC_382|Compound:3229-0966|FD-Score:3.41|P-value:8.30E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.91|P-value:1.61E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.93|P-value:1.34E-10 ID:SGTC_582|Compound:0987-0078|FD-Score:4.10|P-value:7.99E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.40|P-value:8.75E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.72|P-value:3.09E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.15|P-value:8.14E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.94|P-value:1.45E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.15|P-value:1.39E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.60|P-value:1.33E-7 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.61|P-value:4.49E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.69|P-value:4.03E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.89|P-value:2.05E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.65|P-value:4.52E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.63|P-value:4.19E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-4.03|P-value:1.25E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.42|P-value:8.05E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.57|P-value:5.99E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.04|P-value:1.22E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.61|P-value:4.39E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.51|P-value:6.13E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-11.80|P-value:2.07E-27 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.21|P-value:1.04E-6 ID:SGTC_2709|Compound:st078560|FD-Score:-3.95|P-value:1.66E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.88|P-value:1.79E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.97|P-value:3.09E-6 ID:SGTC_2959|Compound:9079155|FD-Score:-3.51|P-value:7.25E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.78|P-value:6.83E-6 ID:SGTC_3024|Compound:9090631|FD-Score:-3.99|P-value:1.46E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.56|P-value:5.15E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-5.81|P-value:6.16E-8 ID:SGTC_3127|Compound:9126946|FD-Score:-3.75|P-value:3.28E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.99|P-value:1.45E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.31|P-value:3.61E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.80|P-value:6.26E-6 ID:SGTC_15|Compound:0266-0086|FD-Score:3.96|P-value:1.35E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.72|P-value:3.58E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.37|P-value:9.56E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-5.08|P-value:1.90E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-7.00|P-value:9.12E-11 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.71|P-value:9.19E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.60|P-value:2.21E-15 ID:SGTC_382|Compound:3229-0966|FD-Score:3.41|P-value:8.30E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.91|P-value:1.61E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.93|P-value:1.34E-10 ID:SGTC_582|Compound:0987-0078|FD-Score:4.10|P-value:7.99E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.40|P-value:8.75E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.72|P-value:3.09E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.15|P-value:8.14E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.94|P-value:1.45E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.15|P-value:1.39E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.60|P-value:1.33E-7 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.61|P-value:4.49E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.69|P-value:4.03E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.89|P-value:2.05E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.65|P-value:4.52E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.63|P-value:4.19E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-4.03|P-value:1.25E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.42|P-value:8.05E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.57|P-value:5.99E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.04|P-value:1.22E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.61|P-value:4.39E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.51|P-value:6.13E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-11.80|P-value:2.07E-27 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.21|P-value:1.04E-6 ID:SGTC_2709|Compound:st078560|FD-Score:-3.95|P-value:1.66E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.88|P-value:1.79E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.97|P-value:3.09E-6 ID:SGTC_2959|Compound:9079155|FD-Score:-3.51|P-value:7.25E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.78|P-value:6.83E-6 ID:SGTC_3024|Compound:9090631|FD-Score:-3.99|P-value:1.46E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.56|P-value:5.15E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-5.81|P-value:6.16E-8 ID:SGTC_3127|Compound:9126946|FD-Score:-3.75|P-value:3.28E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.99|P-value:1.45E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.31|P-value:3.61E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.80|P-value:6.26E-6

Top fitness defect scores for YGR159C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1134 3477-0009 5.60 42.5 µM 1.33E-7 10 1.06E-8
2 SGTC_3194 9111903 4.31 49.5 µM 3.61E-5 14 8.00E-6
3 SGTC_582 0987-0078 4.10 156.0 µM 7.99E-5 calcium & mitochondrial duress 61 2.04E-5
4 SGTC_15 0266-0086 3.96 27.1 µM 1.35E-4 endomembrane recycling 61 3.80E-5
5 SGTC_1060 3448-7350 3.94 82.0 µM 1.45E-4 Golgi 36 4.13E-5
6 SGTC_445 e6 berbamine 3.91 66.0 µM 1.61E-4 NEO1-PIK1 111 4.67E-5
7 SGTC_2870 9038528 3.88 13.0 µM 1.79E-4 19 5.27E-5
8 SGTC_800 3448-7362 3.72 155.0 µM 3.09E-4 translation 182 1.00E-4
9 SGTC_1732 st034308 3.63 51.8 µM 4.19E-4 33 1.44E-4
10 SGTC_2496 diffractaic acid 3.61 79.8 µM 4.39E-4 23 1.52E-4
11 SGTC_1582 3',3',6'-trihydroxyflavone 3.61 74.0 µM 4.49E-4 12 1.56E-4
12 SGTC_3094 9117742 3.56 49.5 µM 5.15E-4 33 1.83E-4
13 SGTC_2540 epiandrosterone 3.51 100.0 µM 6.13E-4 78 2.25E-4
14 SGTC_1914 st062367 3.42 72.6 µM 8.05E-4 35 3.09E-4
15 SGTC_382 3229-0966 3.41 23.2 µM 8.30E-4 40 3.21E-4
16 SGTC_673 1082-0474 3.40 110.0 µM 8.75E-4 RSC complex & mRNA processing 92 3.41E-4
17 SGTC_146 3448-8650 3.37 53.1 µM 9.56E-4 NEO1-PIK1 187 3.78E-4
18 SGTC_1911 st060208 3.33 74.3 µM 0.00107 56 4.34E-4
19 SGTC_1729 st035615 3.19 46.0 µM 0.00163 63 7.10E-4
20 SGTC_2484 5809818 3.07 12.0 µM 0.00234 50 0.00108

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.256 2.41E-51 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.245 5.42E-47 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.212 1.94E-35 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.205 3.77E-33 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.198 5.61E-31 YGL188C-A_p YGL188C-A_p hom Putative protein of unknown function
0.193 1.36E-29 YBL071W-A KTI11 hom Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs
0.188 3.54E-28 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.187 9.90E-28 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.184 8.01E-27 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.174 2.36E-24 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.172 1.25E-23 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.171 2.15E-23 YJR063W RPA12 hom RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
0.166 4.76E-22 YDR156W RPA14 hom RNA polymerase I subunit A14
0.165 6.00E-22 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.165 7.61E-22 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis