YGR160W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR160W / YGR160W

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.41|P-value:2.72E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.07|P-value:2.01E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.89|P-value:4.29E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-3.29|P-value:6.87E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.43|P-value:4.14E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.79|P-value:6.49E-9 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.72|P-value:1.44E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.14|P-value:7.21E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.40|P-value:2.90E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.71|P-value:1.49E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-4.68|P-value:2.26E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:3.39|P-value:2.96E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.32|P-value:3.81E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.42|P-value:4.26E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.15|P-value:7.00E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.56|P-value:4.09E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.34|P-value:3.58E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.82|P-value:9.61E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.10|P-value:8.41E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.08|P-value:8.99E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.22|P-value:8.73E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.46|P-value:2.28E-4 ID:SGTC_2259|Compound:7964009|FD-Score:-3.42|P-value:4.37E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-4.81|P-value:1.21E-6 ID:SGTC_2398|Compound:5228213|FD-Score:-3.57|P-value:2.48E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.61|P-value:1.80E-8 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.50|P-value:1.98E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.99|P-value:4.94E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.83|P-value:9.34E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:-4.12|P-value:2.78E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.91|P-value:3.97E-5 ID:SGTC_2826|Compound:7992541|FD-Score:3.06|P-value:9.50E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.60|P-value:2.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.67|P-value:1.73E-4 ID:SGTC_3205|Compound:9113483|FD-Score:6.29|P-value:1.31E-10 ID:SGTC_3209|Compound:9113616|FD-Score:3.26|P-value:4.77E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.39|P-value:4.75E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.85|P-value:1.00E-6 ID:SGTC_3269|Compound:9137823|FD-Score:-3.80|P-value:1.05E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-3.54|P-value:2.79E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.41|P-value:2.72E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.07|P-value:2.01E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.89|P-value:4.29E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-3.29|P-value:6.87E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.43|P-value:4.14E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.79|P-value:6.49E-9 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.72|P-value:1.44E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.14|P-value:7.21E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.40|P-value:2.90E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.71|P-value:1.49E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-4.68|P-value:2.26E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:3.39|P-value:2.96E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.32|P-value:3.81E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.42|P-value:4.26E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.15|P-value:7.00E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.56|P-value:4.09E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.34|P-value:3.58E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.82|P-value:9.61E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.10|P-value:8.41E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.08|P-value:8.99E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.22|P-value:8.73E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.46|P-value:2.28E-4 ID:SGTC_2259|Compound:7964009|FD-Score:-3.42|P-value:4.37E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-4.81|P-value:1.21E-6 ID:SGTC_2398|Compound:5228213|FD-Score:-3.57|P-value:2.48E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.61|P-value:1.80E-8 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.50|P-value:1.98E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.99|P-value:4.94E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.83|P-value:9.34E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:-4.12|P-value:2.78E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.91|P-value:3.97E-5 ID:SGTC_2826|Compound:7992541|FD-Score:3.06|P-value:9.50E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.60|P-value:2.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.67|P-value:1.73E-4 ID:SGTC_3205|Compound:9113483|FD-Score:6.29|P-value:1.31E-10 ID:SGTC_3209|Compound:9113616|FD-Score:3.26|P-value:4.77E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.39|P-value:4.75E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.85|P-value:1.00E-6 ID:SGTC_3269|Compound:9137823|FD-Score:-3.80|P-value:1.05E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-3.54|P-value:2.79E-4

Top fitness defect scores for YGR160W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3205 9113483 6.29 49.5 µM 1.31E-10 3 1.55E-10
2 SGTC_130 0136-0219 4.07 337.7 µM 2.01E-5 19 2.38E-5
3 SGTC_2821 7996764 3.91 71.4 µM 3.97E-5 42 4.70E-5
4 SGTC_140 0062-0056 3.89 502.5 µM 4.29E-5 24 5.08E-5
5 SGTC_939 1165-0479 3.63 45.3 µM 1.20E-4 44 1.41E-4
6 SGTC_2732 terfenadine 3.50 20.0 µM 1.98E-4 ERG2 9 2.33E-4
7 SGTC_2083 5306046 3.46 65.9 µM 2.28E-4 45 2.68E-4
8 SGTC_118 0083-0097 3.41 135.3 µM 2.72E-4 translation 205 3.20E-4
9 SGTC_544 k015-0020 3.40 52.4 µM 2.90E-4 25 3.41E-4
10 SGTC_604 1000-0114 3.39 314.0 µM 2.96E-4 46 3.48E-4
11 SGTC_791 1348-1292 3.34 225.0 µM 3.58E-4 67 4.20E-4
12 SGTC_625 k213-0058 3.32 121.0 µM 3.81E-4 translation 170 4.48E-4
13 SGTC_3209 9113616 3.26 49.5 µM 4.77E-4 59 5.59E-4
14 SGTC_766 1391-0721 3.15 126.0 µM 7.00E-4 47 8.20E-4
15 SGTC_435 c-PAF 3.14 6.7 µM 7.21E-4 90 8.45E-4
16 SGTC_1624 st003710 3.10 6.2 µM 8.41E-4 calcium & mitochondrial duress 84 9.84E-4
17 SGTC_1695 st026914 3.08 34.5 µM 8.99E-4 58 0.00105
18 SGTC_2826 7992541 3.06 19.5 µM 9.50E-4 46 0.00111
19 SGTC_2033 5192550 3.01 145.0 µM 0.00111 46 0.00129
20 SGTC_817 1391-0715 2.98 46.0 µM 0.00122 50 0.00142

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.214 5.68E-36 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.205 3.77E-33 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.186 1.33E-27 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.167 2.29E-22 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.147 1.21E-17 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.146 1.65E-17 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.146 2.12E-17 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.142 1.31E-16 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.140 3.51E-16 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.139 7.73E-16 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.133 1.03E-14 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.129 6.94E-14 YPR132W RPS23B hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.126 2.12E-13 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.123 7.27E-13 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.120 2.58E-12 YPR159W KRE6 hom Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p