YGR165W / MRPS35

Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR165W / MRPS35

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.60|P-value:4.87E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.39|P-value:1.02E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.08|P-value:2.74E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.04|P-value:3.14E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.86|P-value:5.01E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:13.40|P-value:2.16E-30 ID:SGTC_195|Compound:4234-0266|FD-Score:4.85|P-value:2.00E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.97|P-value:3.84E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.30|P-value:8.14E-26 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.49|P-value:1.91E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:15.30|P-value:1.19E-38 ID:SGTC_314|Compound:1671-0008|FD-Score:4.21|P-value:1.84E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-4.13|P-value:2.12E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.70|P-value:6.06E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:6.47|P-value:2.09E-8 ID:SGTC_385|Compound:1494-0393|FD-Score:3.67|P-value:9.43E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.55|P-value:1.28E-6 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.84|P-value:2.06E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.29|P-value:1.27E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.67|P-value:9.62E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:5.00|P-value:1.12E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.38|P-value:1.04E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.54|P-value:6.11E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:5.12|P-value:7.30E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:4.86|P-value:1.95E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.30|P-value:1.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.77|P-value:7.11E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.36|P-value:2.84E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.10|P-value:2.61E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:6.22|P-value:6.71E-8 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.87|P-value:5.29E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-4.21|P-value:1.63E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.67|P-value:9.49E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.27|P-value:1.51E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.42|P-value:9.04E-5 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.75|P-value:2.86E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.71|P-value:8.57E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.21|P-value:1.66E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.76|P-value:7.40E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.43|P-value:1.84E-6 ID:SGTC_1742|Compound:st038235|FD-Score:6.74|P-value:5.45E-9 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.11|P-value:2.52E-4 ID:SGTC_1921|Compound:5740136|FD-Score:7.07|P-value:9.98E-10 ID:SGTC_1922|Compound:5578187|FD-Score:4.33|P-value:1.24E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-4.35|P-value:1.03E-4 ID:SGTC_2014|Compound:4013930|FD-Score:7.35|P-value:2.28E-10 ID:SGTC_2021|Compound:4019055|FD-Score:-9.90|P-value:1.73E-17 ID:SGTC_2052|Compound:5265182|FD-Score:-3.73|P-value:7.38E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-5.95|P-value:1.99E-7 ID:SGTC_2127|Compound:5253358|FD-Score:4.50|P-value:7.00E-5 ID:SGTC_2136|Compound:5328288|FD-Score:-4.87|P-value:1.63E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.05|P-value:3.00E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.35|P-value:2.90E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.84|P-value:5.70E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.82|P-value:6.21E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-3.85|P-value:5.04E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.92|P-value:4.16E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.39|P-value:1.01E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-5.04|P-value:8.63E-6 ID:SGTC_2526|Compound:patulin|FD-Score:5.65|P-value:8.44E-7 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.02|P-value:3.31E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-5.50|P-value:1.40E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.61|P-value:4.79E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.68|P-value:3.27E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:-5.31|P-value:3.05E-6 ID:SGTC_2643|Compound:anethole|FD-Score:4.20|P-value:1.86E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.51|P-value:6.74E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.19|P-value:1.78E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.78|P-value:6.95E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.25|P-value:3.86E-6 ID:SGTC_2881|Compound:9058953|FD-Score:3.72|P-value:8.23E-4 ID:SGTC_2882|Compound:9058044|FD-Score:5.30|P-value:3.57E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-4.18|P-value:1.81E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.64|P-value:9.57E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-4.18|P-value:1.84E-4 ID:SGTC_3163|Compound:9099914|FD-Score:4.03|P-value:3.20E-4 ID:SGTC_3167|Compound:9103034|FD-Score:4.31|P-value:1.33E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.60|P-value:4.91E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-5.02|P-value:9.36E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:4.60|P-value:4.87E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.39|P-value:1.02E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.08|P-value:2.74E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.04|P-value:3.14E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.86|P-value:5.01E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:13.40|P-value:2.16E-30 ID:SGTC_195|Compound:4234-0266|FD-Score:4.85|P-value:2.00E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.97|P-value:3.84E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.30|P-value:8.14E-26 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.49|P-value:1.91E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:15.30|P-value:1.19E-38 ID:SGTC_314|Compound:1671-0008|FD-Score:4.21|P-value:1.84E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-4.13|P-value:2.12E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.70|P-value:6.06E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:6.47|P-value:2.09E-8 ID:SGTC_385|Compound:1494-0393|FD-Score:3.67|P-value:9.43E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.55|P-value:1.28E-6 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.84|P-value:2.06E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.29|P-value:1.27E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.67|P-value:9.62E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:5.00|P-value:1.12E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.38|P-value:1.04E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.54|P-value:6.11E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:5.12|P-value:7.30E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:4.86|P-value:1.95E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.30|P-value:1.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.77|P-value:7.11E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.36|P-value:2.84E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.10|P-value:2.61E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:6.22|P-value:6.71E-8 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.87|P-value:5.29E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-4.21|P-value:1.63E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.67|P-value:9.49E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.27|P-value:1.51E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.42|P-value:9.04E-5 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.75|P-value:2.86E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.71|P-value:8.57E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.21|P-value:1.66E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.76|P-value:7.40E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.43|P-value:1.84E-6 ID:SGTC_1742|Compound:st038235|FD-Score:6.74|P-value:5.45E-9 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.11|P-value:2.52E-4 ID:SGTC_1921|Compound:5740136|FD-Score:7.07|P-value:9.98E-10 ID:SGTC_1922|Compound:5578187|FD-Score:4.33|P-value:1.24E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-4.35|P-value:1.03E-4 ID:SGTC_2014|Compound:4013930|FD-Score:7.35|P-value:2.28E-10 ID:SGTC_2021|Compound:4019055|FD-Score:-9.90|P-value:1.73E-17 ID:SGTC_2052|Compound:5265182|FD-Score:-3.73|P-value:7.38E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-5.95|P-value:1.99E-7 ID:SGTC_2127|Compound:5253358|FD-Score:4.50|P-value:7.00E-5 ID:SGTC_2136|Compound:5328288|FD-Score:-4.87|P-value:1.63E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.05|P-value:3.00E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.35|P-value:2.90E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.84|P-value:5.70E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.82|P-value:6.21E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-3.85|P-value:5.04E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.92|P-value:4.16E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.39|P-value:1.01E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-5.04|P-value:8.63E-6 ID:SGTC_2526|Compound:patulin|FD-Score:5.65|P-value:8.44E-7 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.02|P-value:3.31E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-5.50|P-value:1.40E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.61|P-value:4.79E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.68|P-value:3.27E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:-5.31|P-value:3.05E-6 ID:SGTC_2643|Compound:anethole|FD-Score:4.20|P-value:1.86E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.51|P-value:6.74E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.19|P-value:1.78E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.78|P-value:6.95E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.25|P-value:3.86E-6 ID:SGTC_2881|Compound:9058953|FD-Score:3.72|P-value:8.23E-4 ID:SGTC_2882|Compound:9058044|FD-Score:5.30|P-value:3.57E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-4.18|P-value:1.81E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.64|P-value:9.57E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-4.18|P-value:1.84E-4 ID:SGTC_3163|Compound:9099914|FD-Score:4.03|P-value:3.20E-4 ID:SGTC_3167|Compound:9103034|FD-Score:4.31|P-value:1.33E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.60|P-value:4.91E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-5.02|P-value:9.36E-6

Top fitness defect scores for YGR165W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 15.30 1.1 µM 1.19E-38 mitochondrial stress 7 7.74E-53
2 SGTC_173 1273-0061 13.40 2.7 µM 2.16E-30 mitochondrial stress 13 2.08E-41
3 SGTC_236 1509-0011 12.30 5.3 µM 8.14E-26 145 4.45E-35
4 SGTC_2014 4013930 7.35 200.0 µM 2.28E-10 2 9.82E-14
5 SGTC_1921 5740136 7.07 50.0 µM 9.98E-10 TRP & mitochondrial translation 9 7.51E-13
6 SGTC_1742 st038235 6.74 28.9 µM 5.45E-9 mitochondrial stress 29 7.80E-12
7 SGTC_275 trichlorophene 6.49 5.7 µM 1.91E-8 mitochondrial stress 101 4.37E-11
8 SGTC_358 0075-0058 6.47 9.4 µM 2.09E-8 14 4.95E-11
9 SGTC_1166 k206-0078 6.22 225.0 µM 6.71E-8 4 2.47E-10
10 SGTC_2526 patulin 5.65 37.6 µM 8.44E-7 30 8.03E-9
11 SGTC_503 tyrphostin 8 5.55 294.0 µM 1.28E-6 TSC3-RPN4 6 1.42E-8
12 SGTC_1129 3453-1384 5.36 223.0 µM 2.84E-6 16 4.26E-8
13 SGTC_2250 alverine citrate 5.35 130.0 µM 2.90E-6 80 4.38E-8
14 SGTC_2882 9058044 5.30 58.4 µM 3.57E-6 5 5.84E-8
15 SGTC_832 4083-0019 5.12 164.0 µM 7.30E-6 translation 35 1.55E-7
16 SGTC_629 3448-6466 5.00 76.7 µM 1.12E-5 4 2.80E-7
17 SGTC_908 3448-7491 4.86 47.7 µM 1.95E-5 mitochondrial stress 83 5.97E-7
18 SGTC_195 4234-0266 4.85 16.6 µM 2.00E-5 15 6.18E-7
19 SGTC_511 blebbistatin 4.84 171.0 µM 2.06E-5 DNA intercalators 10 6.43E-7
20 SGTC_1478 0453-0656 4.75 35.7 µM 2.86E-5 7 1.01E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.491 8.30E-202 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.481 1.09E-193 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.454 4.53E-170 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.453 3.30E-169 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.431 1.83E-151 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.428 2.11E-149 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.425 1.89E-146 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.423 1.21E-145 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.423 2.45E-145 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.422 4.35E-145 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.422 3.96E-145 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.421 3.10E-144 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.416 1.15E-140 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.416 5.47E-140 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.414 9.26E-139 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase