HIPHOP chemogenomics database

YGR174C / CBP4

Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR174C / CBP4

Click on Significant Values for Screen Details

Top fitness defect scores for YGR174C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	19.50	5.3 µM	6.32E-91		59	3.56E-85
2	SGTC_1635	st007035	15.50	42.4 µM	3.97E-58		35	1.67E-54
3	SGTC_2856	9022925	7.72	19.5 µM	7.30E-16		1	5.80E-15
4	SGTC_2627	acetyl isogambogic acid	6.85	100.0 µM	7.02E-13	TSC3-RPN4	10	3.60E-12
5	SGTC_1320	1313-0481	6.35	95.3 µM	2.59E-11		4	1.06E-10
6	SGTC_15	0266-0086	6.26	27.1 µM	5.01E-11	endomembrane recycling	16	1.96E-10
7	SGTC_920	mycophenolic acid	6.17	780.4 nM	9.21E-11		2	3.47E-10
8	SGTC_977	1348-1378	5.74	135.0 µM	1.49E-9		5	4.72E-9
9	SGTC_134	0269-0018	5.62	6.9 µM	3.13E-9		87	9.44E-9
10	SGTC_666	0272-0154	5.06	136.0 µM	8.39E-8	cell wall	28	2.06E-7
11	SGTC_2717	st081029	4.90	62.3 µM	2.08E-7		5	4.83E-7
12	SGTC_824	1304-0008	4.75	100.0 µM	4.49E-7	DNA damage response	24	9.94E-7
13	SGTC_1698	5-fluorocytosine	4.67	1.1 µM	7.10E-7	exosome	4	1.53E-6
14	SGTC_1149	3909-7961	4.51	23.3 µM	1.60E-6		7	3.28E-6
15	SGTC_2711	st079103	4.34	59.1 µM	3.75E-6		4	7.28E-6
16	SGTC_2576	guaiol	4.25	23.1 µM	5.61E-6		12	1.06E-5
17	SGTC_919	tnp00227	4.23	403.6 nM	6.24E-6	RNA pol III & RNase P/MRP	25	1.17E-5
18	SGTC_159	3970-0959	4.23	50.0 µM	6.33E-6		65	1.19E-5
19	SGTC_781	4335-2806	4.01	94.4 µM	1.72E-5		19	3.04E-5
20	SGTC_2716	st080858	3.98	38.6 µM	2.01E-5	60S ribosome export	21	3.51E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.551	2.73E-266	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.524	1.49E-235	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.519	1.80E-230	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.514	7.35E-226	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.513	1.24E-224	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.506	3.94E-218	YPL132W	COX11	hom	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.501	2.61E-212	YGR183C	QCR9	hom	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.499	1.44E-210	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.497	1.29E-208	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.496	3.52E-208	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.493	4.08E-205	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.489	1.83E-201	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.480	2.74E-192	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.472	8.79E-186	YLR038C	COX12	hom	Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.469	1.62E-183	YER058W	PET117	hom	Protein required for assembly of cytochrome c oxidase