YGR174W-A_p

Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR174W-A / YGR174W-A

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.14|P-value:1.93E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:2.86|P-value:6.23E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.72|P-value:4.64E-8 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.01|P-value:3.32E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.75|P-value:1.04E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.30|P-value:9.73E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-2.98|P-value:3.53E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.37|P-value:6.55E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:2.82|P-value:7.18E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.83|P-value:7.45E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:-2.75|P-value:9.05E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:2.97|P-value:4.07E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.27|P-value:1.02E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.78|P-value:8.34E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.81|P-value:8.38E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:-2.80|P-value:7.44E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-4.16|P-value:1.14E-6 ID:SGTC_1635|Compound:st007035|FD-Score:2.92|P-value:4.82E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-3.17|P-value:1.60E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.41|P-value:5.95E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.83|P-value:7.39E-6 ID:SGTC_2126|Compound:5251174|FD-Score:3.14|P-value:1.94E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.12|P-value:2.15E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.39|P-value:3.20E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:2.81|P-value:7.42E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.10|P-value:2.34E-4 ID:SGTC_2379|Compound:9035213|FD-Score:2.75|P-value:9.53E-4 ID:SGTC_2381|Compound:9035592|FD-Score:2.90|P-value:5.41E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-4.39|P-value:3.09E-7 ID:SGTC_2424|Compound:5537928|FD-Score:-3.32|P-value:8.13E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:2.96|P-value:4.24E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.10|P-value:2.11E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.09|P-value:2.25E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.65|P-value:1.68E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.44|P-value:5.05E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.04|P-value:2.79E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.83|P-value:6.70E-6 ID:SGTC_38|Compound:0929-0051|FD-Score:3.14|P-value:1.93E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:2.86|P-value:6.23E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.72|P-value:4.64E-8 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.01|P-value:3.32E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.75|P-value:1.04E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.30|P-value:9.73E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-2.98|P-value:3.53E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.37|P-value:6.55E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:2.82|P-value:7.18E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.83|P-value:7.45E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:-2.75|P-value:9.05E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:2.97|P-value:4.07E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.27|P-value:1.02E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.78|P-value:8.34E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.81|P-value:8.38E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:-2.80|P-value:7.44E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-4.16|P-value:1.14E-6 ID:SGTC_1635|Compound:st007035|FD-Score:2.92|P-value:4.82E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-3.17|P-value:1.60E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.41|P-value:5.95E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.83|P-value:7.39E-6 ID:SGTC_2126|Compound:5251174|FD-Score:3.14|P-value:1.94E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.12|P-value:2.15E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.39|P-value:3.20E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:2.81|P-value:7.42E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.10|P-value:2.34E-4 ID:SGTC_2379|Compound:9035213|FD-Score:2.75|P-value:9.53E-4 ID:SGTC_2381|Compound:9035592|FD-Score:2.90|P-value:5.41E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-4.39|P-value:3.09E-7 ID:SGTC_2424|Compound:5537928|FD-Score:-3.32|P-value:8.13E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:2.96|P-value:4.24E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.10|P-value:2.11E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.09|P-value:2.25E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.65|P-value:1.68E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.44|P-value:5.05E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.04|P-value:2.79E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.83|P-value:6.70E-6

Top fitness defect scores for YGR174W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 4.72 5.3 µM 4.64E-8 342 1.16E-6
2 SGTC_2057 5236571 3.83 38.3 µM 7.39E-6 RPP1 & pyrimidine depletion 34 6.31E-5
3 SGTC_822 1487-0950 3.83 154.0 µM 7.45E-6 16 6.35E-5
4 SGTC_1224 0823-0416 3.81 294.0 µM 8.38E-6 9 6.97E-5
5 SGTC_2933 9026794 3.44 32.5 µM 5.05E-5 45 2.88E-4
6 SGTC_1792 st045773 3.41 43.6 µM 5.95E-5 48 3.29E-4
7 SGTC_359 0081-0058 3.30 15.9 µM 9.73E-5 60S ribosome export 80 4.85E-4
8 SGTC_38 0929-0051 3.14 58.3 µM 1.93E-4 56 8.36E-4
9 SGTC_2126 5251174 3.14 33.9 µM 1.94E-4 78 8.38E-4
10 SGTC_2130 NSC 7 3.12 2.5 µM 2.15E-4 copper-dependent oxidative stress 80 9.10E-4
11 SGTC_2297 7971671 3.10 152.3 µM 2.34E-4 RNA processing & uracil transport 59 9.75E-4
12 SGTC_270 tamoxifen 3.01 5.5 µM 3.32E-4 NEO1 83 0.00129
13 SGTC_978 1416-0512 2.97 87.4 µM 4.07E-4 redox potentiating 68 0.00151
14 SGTC_2581 avocatin a 2.96 64.0 µM 4.24E-4 sphingolipid biosynthesis & PDR1 100 0.00156
15 SGTC_1635 st007035 2.92 42.4 µM 4.82E-4 302 0.00173
16 SGTC_2381 9035592 2.90 200.0 µM 5.41E-4 66 0.00190
17 SGTC_183 3914-0051 2.86 30.6 µM 6.23E-4 60S ribosome export 74 0.00212
18 SGTC_737 1950-0117 2.82 57.9 µM 7.18E-4 74 0.00238
19 SGTC_2247 cerulenin 2.81 830.0 nM 7.42E-4 71 0.00244
20 SGTC_1128 3448-9350 2.78 235.0 µM 8.34E-4 80 0.00268

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.17E-38 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.212 1.89E-35 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.209 1.66E-34 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.204 1.09E-32 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.201 8.52E-32 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.199 2.40E-31 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.198 7.61E-31 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.192 4.43E-29 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.192 4.30E-29 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.191 7.41E-29 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.189 1.98E-28 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.188 4.21E-28 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.185 3.75E-27 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.182 1.90E-26 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.181 3.67E-26 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit