YGR178C / PBP1

Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR178C / PBP1

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.78|P-value:1.89E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:11.00|P-value:2.36E-25 ID:SGTC_43|Compound:0570-0105|FD-Score:7.39|P-value:1.91E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.48|P-value:6.61E-10 ID:SGTC_90|Compound:0870-0863|FD-Score:4.32|P-value:2.45E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.72|P-value:4.52E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:3.61|P-value:3.45E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.91|P-value:1.16E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.62|P-value:3.26E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:5.67|P-value:5.08E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.66|P-value:2.90E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.94|P-value:1.93E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.55|P-value:4.64E-4 ID:SGTC_398|Compound:bronopol|FD-Score:5.31|P-value:2.96E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.69|P-value:5.20E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.95|P-value:1.11E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.41|P-value:1.72E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.47|P-value:5.51E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.23|P-value:3.54E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.35|P-value:8.08E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.53|P-value:4.44E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.38|P-value:7.21E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.45|P-value:5.78E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.46|P-value:5.69E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.43|P-value:6.19E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.80|P-value:3.26E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.78|P-value:1.89E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.30|P-value:9.51E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.54|P-value:4.29E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.65|P-value:6.16E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.20|P-value:2.93E-9 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.94|P-value:1.04E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.62|P-value:3.27E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.85|P-value:2.55E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.41|P-value:6.69E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.46|P-value:1.38E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-5.08|P-value:1.04E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-3.63|P-value:3.46E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.17|P-value:8.64E-15 ID:SGTC_1760|Compound:st045453|FD-Score:4.57|P-value:8.81E-6 ID:SGTC_1800|Compound:st050079|FD-Score:5.37|P-value:2.20E-7 ID:SGTC_1801|Compound:st050089|FD-Score:5.29|P-value:3.27E-7 ID:SGTC_1803|Compound:st050068|FD-Score:6.12|P-value:4.48E-9 ID:SGTC_1855|Compound:st056195|FD-Score:3.36|P-value:7.83E-4 ID:SGTC_1908|Compound:st060353|FD-Score:5.66|P-value:5.24E-8 ID:SGTC_1916|Compound:st067606|FD-Score:3.72|P-value:2.34E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-4.02|P-value:8.76E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.66|P-value:2.90E-4 ID:SGTC_1934|Compound:st074720|FD-Score:13.40|P-value:1.04E-36 ID:SGTC_2038|Compound:4100038|FD-Score:4.35|P-value:2.12E-5 ID:SGTC_2066|Compound:5222451|FD-Score:5.04|P-value:1.06E-6 ID:SGTC_2082|Compound:5219693|FD-Score:4.43|P-value:1.55E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.43|P-value:6.29E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.65|P-value:2.96E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.38|P-value:7.21E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.64|P-value:3.09E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.51|P-value:4.83E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.69|P-value:5.22E-6 ID:SGTC_2434|Compound:5670830|FD-Score:-3.87|P-value:1.51E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.82|P-value:1.65E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.79|P-value:3.39E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.76|P-value:3.82E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.12|P-value:5.40E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.45|P-value:1.41E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.32|P-value:8.93E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.76|P-value:2.00E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.54|P-value:4.70E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.61|P-value:3.75E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.85|P-value:2.61E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.54|P-value:4.37E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.66|P-value:3.13E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.01|P-value:7.98E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.35|P-value:2.12E-5 ID:SGTC_3251|Compound:9135047|FD-Score:4.06|P-value:6.62E-5 ID:SGTC_3303|Compound:9125618|FD-Score:3.67|P-value:2.76E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.59|P-value:3.96E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.78|P-value:1.89E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:11.00|P-value:2.36E-25 ID:SGTC_43|Compound:0570-0105|FD-Score:7.39|P-value:1.91E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.48|P-value:6.61E-10 ID:SGTC_90|Compound:0870-0863|FD-Score:4.32|P-value:2.45E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.72|P-value:4.52E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:3.61|P-value:3.45E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.91|P-value:1.16E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.62|P-value:3.26E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:5.67|P-value:5.08E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.66|P-value:2.90E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.94|P-value:1.93E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.55|P-value:4.64E-4 ID:SGTC_398|Compound:bronopol|FD-Score:5.31|P-value:2.96E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.69|P-value:5.20E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.95|P-value:1.11E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.41|P-value:1.72E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.47|P-value:5.51E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.23|P-value:3.54E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.35|P-value:8.08E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.53|P-value:4.44E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.38|P-value:7.21E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.45|P-value:5.78E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.46|P-value:5.69E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.43|P-value:6.19E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.80|P-value:3.26E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.78|P-value:1.89E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.30|P-value:9.51E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.54|P-value:4.29E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.65|P-value:6.16E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.20|P-value:2.93E-9 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.94|P-value:1.04E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.62|P-value:3.27E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.85|P-value:2.55E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.41|P-value:6.69E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.46|P-value:1.38E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-5.08|P-value:1.04E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-3.63|P-value:3.46E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.17|P-value:8.64E-15 ID:SGTC_1760|Compound:st045453|FD-Score:4.57|P-value:8.81E-6 ID:SGTC_1800|Compound:st050079|FD-Score:5.37|P-value:2.20E-7 ID:SGTC_1801|Compound:st050089|FD-Score:5.29|P-value:3.27E-7 ID:SGTC_1803|Compound:st050068|FD-Score:6.12|P-value:4.48E-9 ID:SGTC_1855|Compound:st056195|FD-Score:3.36|P-value:7.83E-4 ID:SGTC_1908|Compound:st060353|FD-Score:5.66|P-value:5.24E-8 ID:SGTC_1916|Compound:st067606|FD-Score:3.72|P-value:2.34E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-4.02|P-value:8.76E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.66|P-value:2.90E-4 ID:SGTC_1934|Compound:st074720|FD-Score:13.40|P-value:1.04E-36 ID:SGTC_2038|Compound:4100038|FD-Score:4.35|P-value:2.12E-5 ID:SGTC_2066|Compound:5222451|FD-Score:5.04|P-value:1.06E-6 ID:SGTC_2082|Compound:5219693|FD-Score:4.43|P-value:1.55E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.43|P-value:6.29E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.65|P-value:2.96E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.38|P-value:7.21E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.64|P-value:3.09E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.51|P-value:4.83E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.69|P-value:5.22E-6 ID:SGTC_2434|Compound:5670830|FD-Score:-3.87|P-value:1.51E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.82|P-value:1.65E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.79|P-value:3.39E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.76|P-value:3.82E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.12|P-value:5.40E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.45|P-value:1.41E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.32|P-value:8.93E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.76|P-value:2.00E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.54|P-value:4.70E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.61|P-value:3.75E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.85|P-value:2.61E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.54|P-value:4.37E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.66|P-value:3.13E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.01|P-value:7.98E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.35|P-value:2.12E-5 ID:SGTC_3251|Compound:9135047|FD-Score:4.06|P-value:6.62E-5 ID:SGTC_3303|Compound:9125618|FD-Score:3.67|P-value:2.76E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.59|P-value:3.96E-4

Top fitness defect scores for YGR178C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1934 st074720 13.40 32.6 µM 1.04E-36 2 2.04E-41
2 SGTC_15 0266-0086 11.00 27.1 µM 2.36E-25 endomembrane recycling 3 1.61E-28
3 SGTC_1754 st042065 8.17 16.1 µM 8.64E-15 NEO1-PIK1 53 1.57E-16
4 SGTC_43 0570-0105 7.39 72.5 µM 1.91E-12 ERG2 20 7.13E-14
5 SGTC_1495 4469-0029 6.20 237.0 µM 2.93E-9 48 2.90E-10
6 SGTC_1803 st050068 6.12 52.4 µM 4.48E-9 NEO1-PIK1 79 4.70E-10
7 SGTC_207 4185-0010 5.67 4.5 µM 5.08E-8 endomembrane recycling 47 7.33E-9
8 SGTC_1908 st060353 5.66 56.5 µM 5.24E-8 RPP1 & pyrimidine depletion 11 7.59E-9
9 SGTC_1800 st050079 5.37 29.1 µM 2.20E-7 NEO1-PIK1 62 3.86E-8
10 SGTC_398 bronopol 5.31 33.3 µM 2.96E-7 RNA processing & uracil transport 12 5.39E-8
11 SGTC_1801 st050089 5.29 28.4 µM 3.27E-7 NEO1-PIK1 63 6.02E-8
12 SGTC_528 3492-0019 5.05 172.0 µM 1.03E-6 calcium & mitochondrial duress 154 2.21E-7
13 SGTC_2066 5222451 5.04 176.0 µM 1.06E-6 heme biosynthesis & mitochondrial translocase 13 2.27E-7
14 SGTC_1592 4',5'-dihydroxyflavone 4.85 8.8 µM 2.55E-6 60S ribosome export 3 6.14E-7
15 SGTC_2835 9006588 4.85 71.4 µM 2.61E-6 21 6.30E-7
16 SGTC_1094 duloxetine 4.80 25.4 µM 3.26E-6 RPP1 & pyrimidine depletion 4 8.11E-7
17 SGTC_2550 chrysin dimethyl ether 4.79 71.9 µM 3.39E-6 3 8.45E-7
18 SGTC_2562 3',7'-dimethoxyflavone 4.76 64.9 µM 3.82E-6 12 9.67E-7
19 SGTC_143 4032-1194 4.72 15.7 µM 4.52E-6 35 1.17E-6
20 SGTC_445 e6 berbamine 4.69 66.0 µM 5.20E-6 NEO1-PIK1 74 1.37E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.279 8.47E-61 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.271 1.20E-57 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.268 2.56E-56 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.258 4.79E-52 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.257 1.25E-51 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.254 2.20E-50 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.248 2.26E-48 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.241 1.02E-45 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.237 6.14E-44 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.236 7.91E-44 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.235 1.89E-43 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.234 3.73E-43 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.231 5.61E-42 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.230 2.18E-41 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.228 9.10E-41 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress