YGR183C / QCR9

Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR183C / QCR9

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.38|P-value:3.48E-4 ID:SGTC_13|Compound:0199-0087|FD-Score:3.56|P-value:1.77E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.71|P-value:9.58E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.66|P-value:1.07E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:11.80|P-value:6.86E-33 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.28|P-value:4.58E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:5.68|P-value:5.57E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:22.50|P-value:3.21E-114 ID:SGTC_310|Compound:1273-0058|FD-Score:3.79|P-value:7.10E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:3.28|P-value:4.87E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.48|P-value:2.19E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.72|P-value:8.56E-19 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.95|P-value:3.29E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.61|P-value:1.32E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.24|P-value:5.30E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.74|P-value:8.60E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.46|P-value:2.55E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.81|P-value:6.56E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.86|P-value:5.32E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.30|P-value:4.59E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.25|P-value:5.42E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.49|P-value:2.27E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.19|P-value:6.24E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.21|P-value:5.97E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.43|P-value:2.90E-4 ID:SGTC_1635|Compound:st007035|FD-Score:31.50|P-value:8.57E-221 ID:SGTC_1713|Compound:st033146|FD-Score:-9.45|P-value:7.48E-22 ID:SGTC_1716|Compound:st033144|FD-Score:-6.91|P-value:1.55E-12 ID:SGTC_1717|Compound:st033143|FD-Score:5.14|P-value:1.16E-7 ID:SGTC_1862|Compound:st057513|FD-Score:3.97|P-value:3.28E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.98|P-value:3.18E-5 ID:SGTC_1895|Compound:st058434|FD-Score:6.39|P-value:6.58E-11 ID:SGTC_1900|Compound:st060200|FD-Score:-3.07|P-value:9.70E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.25|P-value:5.06E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.21|P-value:5.88E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.79|P-value:6.94E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.42|P-value:2.99E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.21|P-value:1.17E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.86|P-value:5.18E-5 ID:SGTC_2238|Compound:6671620|FD-Score:3.33|P-value:4.07E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.91|P-value:3.87E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.27|P-value:5.21E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.13|P-value:8.44E-4 ID:SGTC_2469|Compound:5655019|FD-Score:5.45|P-value:2.18E-8 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.17|P-value:6.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.93|P-value:3.97E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-3.71|P-value:9.01E-5 ID:SGTC_3135|Compound:9127742|FD-Score:-3.06|P-value:9.93E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.43|P-value:4.25E-6 ID:SGTC_3154|Compound:9100113|FD-Score:-3.18|P-value:6.62E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.19|P-value:6.82E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.87|P-value:1.75E-9 ID:SGTC_3218|Compound:9131285|FD-Score:3.38|P-value:3.45E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.38|P-value:3.48E-4 ID:SGTC_13|Compound:0199-0087|FD-Score:3.56|P-value:1.77E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.71|P-value:9.58E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.66|P-value:1.07E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:11.80|P-value:6.86E-33 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.28|P-value:4.58E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:5.68|P-value:5.57E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:22.50|P-value:3.21E-114 ID:SGTC_310|Compound:1273-0058|FD-Score:3.79|P-value:7.10E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:3.28|P-value:4.87E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.48|P-value:2.19E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.72|P-value:8.56E-19 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.95|P-value:3.29E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.61|P-value:1.32E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.24|P-value:5.30E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.74|P-value:8.60E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.46|P-value:2.55E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.81|P-value:6.56E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.86|P-value:5.32E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.30|P-value:4.59E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.25|P-value:5.42E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.49|P-value:2.27E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.19|P-value:6.24E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.21|P-value:5.97E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.43|P-value:2.90E-4 ID:SGTC_1635|Compound:st007035|FD-Score:31.50|P-value:8.57E-221 ID:SGTC_1713|Compound:st033146|FD-Score:-9.45|P-value:7.48E-22 ID:SGTC_1716|Compound:st033144|FD-Score:-6.91|P-value:1.55E-12 ID:SGTC_1717|Compound:st033143|FD-Score:5.14|P-value:1.16E-7 ID:SGTC_1862|Compound:st057513|FD-Score:3.97|P-value:3.28E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.98|P-value:3.18E-5 ID:SGTC_1895|Compound:st058434|FD-Score:6.39|P-value:6.58E-11 ID:SGTC_1900|Compound:st060200|FD-Score:-3.07|P-value:9.70E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.25|P-value:5.06E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.21|P-value:5.88E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.79|P-value:6.94E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.42|P-value:2.99E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.21|P-value:1.17E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.86|P-value:5.18E-5 ID:SGTC_2238|Compound:6671620|FD-Score:3.33|P-value:4.07E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.91|P-value:3.87E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.27|P-value:5.21E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.13|P-value:8.44E-4 ID:SGTC_2469|Compound:5655019|FD-Score:5.45|P-value:2.18E-8 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.17|P-value:6.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.93|P-value:3.97E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-3.71|P-value:9.01E-5 ID:SGTC_3135|Compound:9127742|FD-Score:-3.06|P-value:9.93E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.43|P-value:4.25E-6 ID:SGTC_3154|Compound:9100113|FD-Score:-3.18|P-value:6.62E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.19|P-value:6.82E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.87|P-value:1.75E-9 ID:SGTC_3218|Compound:9131285|FD-Score:3.38|P-value:3.45E-4

Top fitness defect scores for YGR183C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 31.50 42.4 µM 8.57E-221 7 9.08E-218
2 SGTC_236 1509-0011 22.50 5.3 µM 3.21E-114 43 1.07E-112
3 SGTC_134 0269-0018 11.80 6.9 µM 6.86E-33 31 1.70E-32
4 SGTC_386 1509-0011 8.72 3.1 µM 8.56E-19 54 1.37E-18
5 SGTC_1895 st058434 6.39 18.3 µM 6.58E-11 1 8.33E-11
6 SGTC_3210 9128157 5.87 49.5 µM 1.75E-9 17 2.13E-9
7 SGTC_176 1486-1328 5.68 72.8 µM 5.57E-9 25 6.68E-9
8 SGTC_2469 5655019 5.45 90.8 µM 2.18E-8 7 2.56E-8
9 SGTC_1717 st033143 5.14 58.0 µM 1.16E-7 21 1.34E-7
10 SGTC_3153 9100258 4.43 49.5 µM 4.25E-6 12 4.70E-6
11 SGTC_2024 5144227 4.21 134.0 µM 1.17E-5 29 1.28E-5
12 SGTC_1868 st057644 3.98 42.7 µM 3.18E-5 36 3.43E-5
13 SGTC_1862 st057513 3.97 3.8 µM 3.28E-5 12 3.54E-5
14 SGTC_2582 agaric acid 3.93 100.0 µM 3.97E-5 redox potentiating 320 4.28E-5
15 SGTC_2163 5671233 3.86 125.0 µM 5.18E-5 28 5.56E-5
16 SGTC_1061 3448-9325 3.86 110.0 µM 5.32E-5 26 5.72E-5
17 SGTC_892 0929-0076 3.81 29.0 µM 6.56E-5 TRP & mitochondrial translation 44 7.03E-5
18 SGTC_2005 4024620 3.79 188.0 µM 6.94E-5 24 7.43E-5
19 SGTC_310 1273-0058 3.79 1.1 µM 7.10E-5 mitochondrial stress 254 7.60E-5
20 SGTC_670 4204-0025 3.74 119.0 µM 8.60E-5 copper-dependent oxidative stress 36 9.18E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.735 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.712 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.695 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.692 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.684 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.674 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.645 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.642 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.637 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.616 0 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.607 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.600 0 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.597 3.95E-323 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.596 1.22E-321 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.593 1.99E-317 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p