YGR189C / CRH1

Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR189C / CRH1

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:3.27|P-value:1.83E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.85|P-value:1.36E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.30|P-value:1.56E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.85|P-value:9.44E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-4.02|P-value:5.94E-6 ID:SGTC_482|Compound:fipronil|FD-Score:3.16|P-value:2.87E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.57|P-value:4.82E-5 ID:SGTC_510|Compound:ag-490|FD-Score:2.92|P-value:7.48E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.36|P-value:1.25E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:2.85|P-value:9.57E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-2.96|P-value:6.17E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.10|P-value:3.63E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:2.97|P-value:6.00E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.25|P-value:2.02E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.34|P-value:1.34E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-2.99|P-value:5.44E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-2.99|P-value:5.56E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.49|P-value:5.00E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.77|P-value:2.02E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:-2.87|P-value:8.80E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.36|P-value:1.29E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.79|P-value:8.81E-8 ID:SGTC_1630|Compound:st005209|FD-Score:3.31|P-value:1.57E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.68|P-value:3.08E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.53|P-value:6.04E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.36|P-value:1.26E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.46|P-value:7.94E-5 ID:SGTC_2136|Compound:5328288|FD-Score:4.17|P-value:2.77E-6 ID:SGTC_2283|Compound:7944793|FD-Score:-3.02|P-value:4.91E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-4.20|P-value:2.34E-6 ID:SGTC_2312|Compound:7706453|FD-Score:-3.59|P-value:4.45E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.67|P-value:3.28E-5 ID:SGTC_2415|Compound:st077333|FD-Score:8.69|P-value:1.43E-21 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.76|P-value:2.12E-5 ID:SGTC_2443|Compound:5493264|FD-Score:-3.07|P-value:3.97E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.71|P-value:2.65E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.16|P-value:2.82E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:-2.99|P-value:5.44E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-4.09|P-value:3.98E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.15|P-value:2.98E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.96|P-value:6.39E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:2.96|P-value:6.38E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.17|P-value:2.78E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.78|P-value:1.90E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.04|P-value:4.75E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.22|P-value:2.22E-4 ID:SGTC_2800|Compound:7887935|FD-Score:2.97|P-value:6.09E-4 ID:SGTC_2880|Compound:9042983|FD-Score:2.89|P-value:8.36E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.23|P-value:2.12E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.68|P-value:3.05E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.67|P-value:3.27E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.16|P-value:2.90E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.27|P-value:1.83E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.85|P-value:1.36E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.30|P-value:1.56E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.85|P-value:9.44E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-4.02|P-value:5.94E-6 ID:SGTC_482|Compound:fipronil|FD-Score:3.16|P-value:2.87E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.57|P-value:4.82E-5 ID:SGTC_510|Compound:ag-490|FD-Score:2.92|P-value:7.48E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.36|P-value:1.25E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:2.85|P-value:9.57E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-2.96|P-value:6.17E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.10|P-value:3.63E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:2.97|P-value:6.00E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.25|P-value:2.02E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.34|P-value:1.34E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-2.99|P-value:5.44E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-2.99|P-value:5.56E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.49|P-value:5.00E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.77|P-value:2.02E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:-2.87|P-value:8.80E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.36|P-value:1.29E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.79|P-value:8.81E-8 ID:SGTC_1630|Compound:st005209|FD-Score:3.31|P-value:1.57E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.68|P-value:3.08E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.53|P-value:6.04E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.36|P-value:1.26E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.46|P-value:7.94E-5 ID:SGTC_2136|Compound:5328288|FD-Score:4.17|P-value:2.77E-6 ID:SGTC_2283|Compound:7944793|FD-Score:-3.02|P-value:4.91E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-4.20|P-value:2.34E-6 ID:SGTC_2312|Compound:7706453|FD-Score:-3.59|P-value:4.45E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.67|P-value:3.28E-5 ID:SGTC_2415|Compound:st077333|FD-Score:8.69|P-value:1.43E-21 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.76|P-value:2.12E-5 ID:SGTC_2443|Compound:5493264|FD-Score:-3.07|P-value:3.97E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.71|P-value:2.65E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.16|P-value:2.82E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:-2.99|P-value:5.44E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-4.09|P-value:3.98E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.15|P-value:2.98E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.96|P-value:6.39E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:2.96|P-value:6.38E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.17|P-value:2.78E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.78|P-value:1.90E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.04|P-value:4.75E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.22|P-value:2.22E-4 ID:SGTC_2800|Compound:7887935|FD-Score:2.97|P-value:6.09E-4 ID:SGTC_2880|Compound:9042983|FD-Score:2.89|P-value:8.36E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.23|P-value:2.12E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.68|P-value:3.05E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.67|P-value:3.27E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.16|P-value:2.90E-4

Top fitness defect scores for YGR189C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2415 st077333 8.69 57.7 µM 1.43E-21 3 1.81E-18
2 SGTC_1170 0310-0127 4.49 64.8 µM 5.00E-7 11 3.54E-6
3 SGTC_2136 5328288 4.17 199.3 µM 2.77E-6 17 1.51E-5
4 SGTC_394 menadione 3.85 8.3 µM 1.36E-5 superoxide 36 5.84E-5
5 SGTC_2761 levamisole 3.78 97.9 µM 1.90E-5 19 7.75E-5
6 SGTC_1175 0741-0056 3.77 27.6 µM 2.02E-5 22 8.17E-5
7 SGTC_2419 paclitaxel 3.76 166.5 µM 2.12E-5 49 8.52E-5
8 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.71 100.0 µM 2.65E-5 28 1.03E-4
9 SGTC_3063 1327-0034 3.68 4.0 µM 3.05E-5 51 1.16E-4
10 SGTC_1951 sophoraflavanone G 3.68 9.2 µM 3.08E-5 RNA processing & uracil transport 35 1.17E-4
11 SGTC_3207 9114163 3.67 49.5 µM 3.27E-5 40 1.23E-4
12 SGTC_2349 9023730 3.67 187.1 µM 3.28E-5 36 1.23E-4
13 SGTC_2006 4011487 3.53 200.0 µM 6.04E-5 endomembrane recycling 104 2.07E-4
14 SGTC_555 4296-0685 3.36 37.0 µM 1.25E-4 ergosterol biosynthesis 26 3.85E-4
15 SGTC_2119 5528445 3.36 120.6 µM 1.26E-4 42 3.87E-4
16 SGTC_1404 3909-7820 3.36 48.3 µM 1.29E-4 60S ribosome export 22 3.96E-4
17 SGTC_1630 st005209 3.31 31.3 µM 1.57E-4 52 4.67E-4
18 SGTC_143 4032-1194 3.27 15.7 µM 1.83E-4 106 5.32E-4
19 SGTC_1028 k015-0029 3.25 4.8 µM 2.02E-4 48 5.79E-4
20 SGTC_2757 clomiphene 3.17 4.2 µM 2.78E-4 fatty acid desaturase (OLE1) 78 7.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 2.26E-35 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.186 1.51E-27 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.155 1.96E-19 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.143 6.92E-17 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.138 8.36E-16 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.132 1.39E-14 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.129 7.22E-14 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.126 2.26E-13 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.118 6.05E-12 YOR219C STE13 hom Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
0.116 1.71E-11 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.114 3.26E-11 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.114 3.48E-11 YJR147W HMS2 hom Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.112 6.68E-11 YDR099W BMH2 hom 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.111 1.30E-10 YEL016C NPP2 hom Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication
0.111 1.37E-10 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data