YGR191W / HIP1

High-affinity histidine permease, also involved in the transport of manganese ions

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR191W / HIP1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:-3.67|P-value:4.59E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.51|P-value:7.69E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.28|P-value:1.54E-11 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.94|P-value:1.57E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.23|P-value:6.30E-9 ID:SGTC_371|Compound:0195-0006|FD-Score:3.54|P-value:5.94E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.58|P-value:5.15E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.21|P-value:5.77E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:7.89|P-value:2.90E-13 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.58|P-value:5.24E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.42|P-value:8.52E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.66|P-value:4.04E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.53|P-value:6.05E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.41|P-value:8.84E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.76|P-value:2.91E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-3.55|P-value:6.73E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.88|P-value:2.26E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.50|P-value:7.83E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.65|P-value:4.93E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.61|P-value:4.71E-4 ID:SGTC_2469|Compound:5655019|FD-Score:-4.29|P-value:5.24E-5 ID:SGTC_2474|Compound:5321570|FD-Score:-3.47|P-value:8.66E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.69|P-value:1.09E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.44|P-value:8.19E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.91|P-value:2.02E-4 ID:SGTC_3347|Compound:9188721|FD-Score:6.11|P-value:1.16E-8 ID:SGTC_39|Compound:0986-0283|FD-Score:-3.67|P-value:4.59E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.51|P-value:7.69E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.28|P-value:1.54E-11 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.94|P-value:1.57E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.23|P-value:6.30E-9 ID:SGTC_371|Compound:0195-0006|FD-Score:3.54|P-value:5.94E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.58|P-value:5.15E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.21|P-value:5.77E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:7.89|P-value:2.90E-13 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.58|P-value:5.24E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.42|P-value:8.52E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.66|P-value:4.04E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.53|P-value:6.05E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.41|P-value:8.84E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.76|P-value:2.91E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-3.55|P-value:6.73E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.88|P-value:2.26E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.50|P-value:7.83E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.65|P-value:4.93E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.61|P-value:4.71E-4 ID:SGTC_2469|Compound:5655019|FD-Score:-4.29|P-value:5.24E-5 ID:SGTC_2474|Compound:5321570|FD-Score:-3.47|P-value:8.66E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.69|P-value:1.09E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.44|P-value:8.19E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.91|P-value:2.02E-4 ID:SGTC_3347|Compound:9188721|FD-Score:6.11|P-value:1.16E-8

Top fitness defect scores for YGR191W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_690 glyoxal 7.89 20.3 µM 2.90E-13 6 1.46E-15 0.12
2 SGTC_236 1509-0011 7.28 5.3 µM 1.54E-11 5 1.71E-13 0.22
3 SGTC_363 0455-0021 6.23 3.1 µM 6.30E-9 azole & statin 7 2.32E-10 0.16
4 SGTC_3347 9188721 6.11 44.7 µM 1.16E-8 7 4.84E-10 0.37
5 SGTC_429 1112-0049 4.21 25.5 µM 5.77E-5 DNA damage response 9 1.26E-5 0.21
6 SGTC_244 nsc-207895 3.94 1.3 µM 1.57E-4 DNA damage response 1 4.16E-5 0.99
7 SGTC_1964 st076914 3.76 61.0 µM 2.91E-4 RPP1 & pyrimidine depletion 8 8.63E-5 0.00
8 SGTC_1159 4092-0538 3.66 61.2 µM 4.04E-4 8 1.28E-4 0.04
9 SGTC_2465 5809242 3.61 33.2 µM 4.71E-4 2 1.53E-4 0.36
10 SGTC_392 N-ethylmaleimide 3.58 8.3 µM 5.15E-4 RNA pol III & RNase P/MRP 17 1.70E-4 0.04
11 SGTC_1015 4130-4525 3.58 82.0 µM 5.24E-4 60S ribosome export 11 1.73E-4 0.16
12 SGTC_371 0195-0006 3.54 7.4 µM 5.94E-4 16 2.01E-4 0.08
13 SGTC_1264 0783-0040 3.53 158.0 µM 6.05E-4 5 2.06E-4 0.04
14 SGTC_2768 sulfasalazine 3.44 50.2 µM 8.19E-4 18 2.95E-4 0.05
15 SGTC_1021 4476-0760 3.42 85.3 µM 8.52E-4 4 3.09E-4 0.17
16 SGTC_1575 cyproterone acetate 3.41 48.0 µM 8.84E-4 12 3.23E-4 0.10
17 SGTC_2762 leflunomide 3.37 42.1 µM 0.00100 9 3.75E-4 0.03
18 SGTC_2633 5,7-dihydroxyisoflavone 3.32 100.0 µM 0.00118 11 4.53E-4 0.10
19 SGTC_254 nsc-64875 3.27 3.8 µM 0.00135 ergosterol depletion effects on membrane 6 5.33E-4 0.12
20 SGTC_2291 7917025 3.25 104.3 µM 0.00144 iron homeostasis 17 5.77E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.331 2.98E-86 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.302 1.64E-71 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.230 2.13E-41 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.217 7.08E-37 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.207 6.31E-34 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.203 1.40E-32 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.202 2.89E-32 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.200 1.63E-31 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.198 8.43E-31 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.193 1.49E-29 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.192 2.86E-29 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.189 2.22E-28 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.189 2.70E-28 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.184 6.22E-27 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.182 2.40E-26 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes