YGR193C / PDX1

Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR193C / PDX1

Click on Significant Values for Screen Details ID:SGTC_159|Compound:3970-0959|FD-Score:3.71|P-value:2.06E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:12.50|P-value:6.22E-43 ID:SGTC_164|Compound:4100-3994|FD-Score:3.05|P-value:3.71E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.12|P-value:3.75E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.37|P-value:1.35E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.29|P-value:1.41E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:4.18|P-value:1.96E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.35|P-value:7.91E-7 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.33|P-value:1.18E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.10|P-value:4.05E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:2.86|P-value:7.57E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.96|P-value:6.94E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:2.83|P-value:8.75E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.29|P-value:1.91E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.00|P-value:7.48E-6 ID:SGTC_996|Compound:3970-0799|FD-Score:5.47|P-value:8.95E-10 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.20|P-value:2.70E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:2.92|P-value:6.22E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.02|P-value:2.47E-8 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.91|P-value:6.39E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.23|P-value:1.77E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.09|P-value:4.29E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.01|P-value:4.41E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-4.24|P-value:2.16E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-3.33|P-value:1.61E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.13|P-value:3.54E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.33|P-value:1.59E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-4.59|P-value:3.24E-7 ID:SGTC_2112|Compound:5488546|FD-Score:-3.13|P-value:3.58E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.43|P-value:7.68E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.40|P-value:8.52E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.00|P-value:6.03E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.72|P-value:1.97E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.47|P-value:6.37E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-3.05|P-value:4.97E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.84|P-value:1.12E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.71|P-value:2.06E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:12.50|P-value:6.22E-43 ID:SGTC_164|Compound:4100-3994|FD-Score:3.05|P-value:3.71E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.12|P-value:3.75E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.37|P-value:1.35E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.29|P-value:1.41E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:4.18|P-value:1.96E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.35|P-value:7.91E-7 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.33|P-value:1.18E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.10|P-value:4.05E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:2.86|P-value:7.57E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.96|P-value:6.94E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:2.83|P-value:8.75E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.29|P-value:1.91E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.00|P-value:7.48E-6 ID:SGTC_996|Compound:3970-0799|FD-Score:5.47|P-value:8.95E-10 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.20|P-value:2.70E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:2.92|P-value:6.22E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.02|P-value:2.47E-8 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.91|P-value:6.39E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.23|P-value:1.77E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.09|P-value:4.29E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.01|P-value:4.41E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-4.24|P-value:2.16E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-3.33|P-value:1.61E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.13|P-value:3.54E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.33|P-value:1.59E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-4.59|P-value:3.24E-7 ID:SGTC_2112|Compound:5488546|FD-Score:-3.13|P-value:3.58E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.43|P-value:7.68E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.40|P-value:8.52E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.00|P-value:6.03E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.72|P-value:1.97E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.47|P-value:6.37E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-3.05|P-value:4.97E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.84|P-value:1.12E-5

Top fitness defect scores for YGR193C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_163 1327-0036 12.50 7.5 µM 6.22E-43 9 4.74E-36
2 SGTC_996 3970-0799 5.47 1.8 µM 8.95E-10 45 2.30E-8
3 SGTC_453 enantio-paf c16 4.35 10.0 µM 7.91E-7 115 6.67E-6
4 SGTC_372 0155-0182 4.18 15.9 µM 1.96E-6 mitochondrial response to ROS 24 1.43E-5
5 SGTC_3347 9188721 3.84 44.7 µM 1.12E-5 27 6.14E-5
6 SGTC_2379 9035213 3.72 200.0 µM 1.97E-5 29 9.80E-5
7 SGTC_159 3970-0959 3.71 50.0 µM 2.06E-5 88 1.02E-4
8 SGTC_2651 1327-0036 3.47 5.0 µM 6.37E-5 201 2.62E-4
9 SGTC_2121 5257820 3.43 149.6 µM 7.68E-5 21 3.07E-4
10 SGTC_2123 5259487 3.40 200.0 µM 8.52E-5 31 3.35E-4
11 SGTC_495 decylubiquinone 3.33 155.0 µM 1.18E-4 copper-dependent oxidative stress 52 4.39E-4
12 SGTC_182 3448-4371 3.29 550.5 µM 1.41E-4 47 5.09E-4
13 SGTC_1263 0774-1208 3.23 64.8 µM 1.77E-4 88 6.17E-4
14 SGTC_164 4100-3994 3.05 89.6 µM 3.71E-4 84 0.00115
15 SGTC_1570 verbenone 3.01 133.0 µM 4.41E-4 50 0.00133
16 SGTC_1026 k007-1105 2.92 30.6 µM 6.22E-4 ERAD & cell cycle 162 0.00177
17 SGTC_1261 0712-0010 2.91 12.7 µM 6.39E-4 RNA processing & uracil transport 76 0.00181
18 SGTC_529 4076-0302 2.86 30.3 µM 7.57E-4 mitochondrial processes 63 0.00209
19 SGTC_628 1636-0253 2.83 16.0 µM 8.75E-4 sphingolipid biosynthesis & PDR1 105 0.00236
20 SGTC_350 k064-0020 2.71 19.8 µM 0.00131 heme requiring 102 0.00331

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.378 3.01E-114 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.342 1.32E-92 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.340 2.67E-91 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.324 1.35E-82 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.307 3.98E-74 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.280 1.35E-61 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.265 5.65E-55 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.261 2.09E-53 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.256 2.49E-51 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.251 2.25E-49 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.248 2.21E-48 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.247 1.15E-47 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.246 1.71E-47 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.236 9.88E-44 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.224 1.93E-39 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly