YGR207C / CIR1

Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR207C / CIR1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.19|P-value:1.18E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.24|P-value:1.13E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.52|P-value:2.44E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:2.70|P-value:9.10E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:2.77|P-value:6.89E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.15|P-value:1.39E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.95|P-value:4.03E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.98|P-value:2.32E-6 ID:SGTC_882|Compound:0843-0131|FD-Score:2.96|P-value:3.21E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.19|P-value:1.46E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.00|P-value:2.64E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.98|P-value:2.89E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.49|P-value:1.54E-7 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.18|P-value:1.49E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-2.95|P-value:3.95E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.72|P-value:1.12E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.30|P-value:7.08E-5 ID:SGTC_2095|Compound:5432005|FD-Score:-3.19|P-value:1.44E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-2.88|P-value:5.35E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.00|P-value:3.22E-4 ID:SGTC_2174|Compound:5790901|FD-Score:2.86|P-value:4.78E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.51|P-value:3.31E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.98|P-value:2.91E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.97|P-value:2.35E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.98|P-value:3.59E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.72|P-value:2.85E-8 ID:SGTC_2625|Compound:euphol|FD-Score:5.05|P-value:3.14E-9 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.84|P-value:6.32E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.19|P-value:1.44E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-2.78|P-value:8.02E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.02|P-value:2.48E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.94|P-value:3.53E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-2.84|P-value:6.32E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.19|P-value:1.18E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.24|P-value:1.13E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.52|P-value:2.44E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:2.70|P-value:9.10E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:2.77|P-value:6.89E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.15|P-value:1.39E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.95|P-value:4.03E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.98|P-value:2.32E-6 ID:SGTC_882|Compound:0843-0131|FD-Score:2.96|P-value:3.21E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.19|P-value:1.46E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.00|P-value:2.64E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.98|P-value:2.89E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.49|P-value:1.54E-7 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.18|P-value:1.49E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-2.95|P-value:3.95E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.72|P-value:1.12E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.30|P-value:7.08E-5 ID:SGTC_2095|Compound:5432005|FD-Score:-3.19|P-value:1.44E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-2.88|P-value:5.35E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.00|P-value:3.22E-4 ID:SGTC_2174|Compound:5790901|FD-Score:2.86|P-value:4.78E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.51|P-value:3.31E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.98|P-value:2.91E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.97|P-value:2.35E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.98|P-value:3.59E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.72|P-value:2.85E-8 ID:SGTC_2625|Compound:euphol|FD-Score:5.05|P-value:3.14E-9 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.84|P-value:6.32E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.19|P-value:1.44E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-2.78|P-value:8.02E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.02|P-value:2.48E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.94|P-value:3.53E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-2.84|P-value:6.32E-4

Top fitness defect scores for YGR207C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2625 euphol 5.05 100.0 µM 3.14E-9 12 2.21E-7
2 SGTC_2620 irigenin 4.72 100.0 µM 2.85E-8 16 1.20E-6
3 SGTC_763 3453-1109 3.98 128.0 µM 2.32E-6 15 3.49E-5
4 SGTC_2493 resveratrol 3.97 26.1 µM 2.35E-6 6 3.52E-5
5 SGTC_156 3474-0145 3.52 5.6 µM 2.44E-5 endomembrane recycling 63 2.13E-4
6 SGTC_2015 5119600 3.30 184.0 µM 7.08E-5 53 4.83E-4
7 SGTC_39 0986-0283 3.19 58.4 µM 1.18E-4 calcium & mitochondrial duress 69 7.18E-4
8 SGTC_511 blebbistatin 3.15 171.0 µM 1.39E-4 DNA intercalators 44 8.11E-4
9 SGTC_3021 9087658 3.02 49.5 µM 2.48E-4 25 0.00127
10 SGTC_986 1493-0483 3.00 84.0 µM 2.64E-4 48 0.00133
11 SGTC_1009 4106-0057 2.98 9.9 µM 2.89E-4 47 0.00143
12 SGTC_2492 derrusnin 2.98 100.0 µM 2.91E-4 25 0.00144
13 SGTC_882 0843-0131 2.96 351.0 µM 3.21E-4 59 0.00155
14 SGTC_3042 9091578 2.94 49.5 µM 3.53E-4 ERG2 30 0.00167
15 SGTC_2174 5790901 2.86 200.0 µM 4.78E-4 tubulin folding & SWR complex 90 0.00211
16 SGTC_440 fluspirilene 2.77 35.1 µM 6.89E-4 84 0.00280
17 SGTC_284 0988-0104 2.70 32.6 µM 9.10E-4 heme requiring 63 0.00346
18 SGTC_2490 carminic acid 2.63 95.4 µM 0.00120 47 0.00429
19 SGTC_2491 paeonol 2.62 100.0 µM 0.00122 50 0.00434
20 SGTC_2619 obliquin 2.56 87.9 µM 0.00152 cell wall 277 0.00517

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 3.37E-48 YDR242W AMD2 hom Putative amidase
0.207 8.32E-34 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.201 6.90E-32 YKL174C TPO5 hom Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
0.190 1.64E-28 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.187 1.11E-27 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.185 2.55E-27 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.183 8.22E-27 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
0.183 1.20E-26 YJR147W HMS2 hom Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.180 8.15E-26 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.172 9.61E-24 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.166 2.89E-22 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.162 4.27E-21 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.161 7.81E-21 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.160 1.03E-20 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.160 1.30E-20 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD