YGR208W / SER2

Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR208W / SER2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:8.98|P-value:4.31E-21 ID:SGTC_18|Compound:0111-0177|FD-Score:12.10|P-value:1.73E-36 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.67|P-value:7.19E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:5.68|P-value:1.60E-9 ID:SGTC_84|Compound:0443-0269|FD-Score:3.67|P-value:6.41E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:6.22|P-value:4.71E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:8.64|P-value:1.20E-19 ID:SGTC_253|Compound:dyclonine|FD-Score:4.82|P-value:2.55E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.43|P-value:1.91E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.87|P-value:2.75E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.50|P-value:1.45E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:4.10|P-value:9.51E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:6.88|P-value:3.97E-13 ID:SGTC_513|Compound:4245-1575|FD-Score:9.71|P-value:2.56E-24 ID:SGTC_707|Compound:0865-0008|FD-Score:-3.91|P-value:2.52E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.50|P-value:1.30E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.12|P-value:6.16E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.35|P-value:2.59E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.63|P-value:8.41E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.60|P-value:9.46E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.37|P-value:2.63E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.49|P-value:1.48E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:8.01|P-value:3.75E-17 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.67|P-value:6.54E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.34|P-value:2.41E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:-3.05|P-value:8.01E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.69|P-value:5.83E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.54|P-value:1.10E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:-4.15|P-value:8.37E-6 ID:SGTC_1498|Compound:4478-3555|FD-Score:4.04|P-value:1.23E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.10|P-value:6.10E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.46|P-value:1.52E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.48|P-value:1.39E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.15|P-value:5.07E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:10.80|P-value:1.25E-29 ID:SGTC_2003|Compound:4023581|FD-Score:-3.00|P-value:9.61E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.04|P-value:7.63E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.55|P-value:1.05E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.67|P-value:7.27E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.01|P-value:8.40E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.45|P-value:1.78E-6 ID:SGTC_2332|Compound:7982454|FD-Score:-5.77|P-value:1.09E-9 ID:SGTC_2336|Compound:9001819|FD-Score:5.14|P-value:4.26E-8 ID:SGTC_2337|Compound:9009472|FD-Score:4.43|P-value:1.89E-6 ID:SGTC_2358|Compound:9037157|FD-Score:3.26|P-value:3.33E-4 ID:SGTC_2370|Compound:9071495|FD-Score:-4.72|P-value:4.86E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.53|P-value:4.14E-9 ID:SGTC_2443|Compound:5493264|FD-Score:3.46|P-value:1.51E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.28|P-value:4.05E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.50|P-value:1.04E-38 ID:SGTC_2716|Compound:st080858|FD-Score:5.86|P-value:5.18E-10 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.54|P-value:1.23E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.22|P-value:5.40E-6 ID:SGTC_2920|Compound:7982904|FD-Score:3.66|P-value:6.57E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.64|P-value:6.40E-7 ID:SGTC_3216|Compound:9129716|FD-Score:-3.87|P-value:3.07E-5 ID:SGTC_3220|Compound:9131269|FD-Score:-3.55|P-value:1.18E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.38|P-value:2.47E-6 ID:SGTC_3253|Compound:9135987|FD-Score:3.90|P-value:2.32E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:8.98|P-value:4.31E-21 ID:SGTC_18|Compound:0111-0177|FD-Score:12.10|P-value:1.73E-36 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.67|P-value:7.19E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:5.68|P-value:1.60E-9 ID:SGTC_84|Compound:0443-0269|FD-Score:3.67|P-value:6.41E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:6.22|P-value:4.71E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:8.64|P-value:1.20E-19 ID:SGTC_253|Compound:dyclonine|FD-Score:4.82|P-value:2.55E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.43|P-value:1.91E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.87|P-value:2.75E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.50|P-value:1.45E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:4.10|P-value:9.51E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:6.88|P-value:3.97E-13 ID:SGTC_513|Compound:4245-1575|FD-Score:9.71|P-value:2.56E-24 ID:SGTC_707|Compound:0865-0008|FD-Score:-3.91|P-value:2.52E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.50|P-value:1.30E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.12|P-value:6.16E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.35|P-value:2.59E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.63|P-value:8.41E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.60|P-value:9.46E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.37|P-value:2.63E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.49|P-value:1.48E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:8.01|P-value:3.75E-17 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.67|P-value:6.54E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.34|P-value:2.41E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:-3.05|P-value:8.01E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.69|P-value:5.83E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.54|P-value:1.10E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:-4.15|P-value:8.37E-6 ID:SGTC_1498|Compound:4478-3555|FD-Score:4.04|P-value:1.23E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.10|P-value:6.10E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.46|P-value:1.52E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.48|P-value:1.39E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.15|P-value:5.07E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:10.80|P-value:1.25E-29 ID:SGTC_2003|Compound:4023581|FD-Score:-3.00|P-value:9.61E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.04|P-value:7.63E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.55|P-value:1.05E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.67|P-value:7.27E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.01|P-value:8.40E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.45|P-value:1.78E-6 ID:SGTC_2332|Compound:7982454|FD-Score:-5.77|P-value:1.09E-9 ID:SGTC_2336|Compound:9001819|FD-Score:5.14|P-value:4.26E-8 ID:SGTC_2337|Compound:9009472|FD-Score:4.43|P-value:1.89E-6 ID:SGTC_2358|Compound:9037157|FD-Score:3.26|P-value:3.33E-4 ID:SGTC_2370|Compound:9071495|FD-Score:-4.72|P-value:4.86E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.53|P-value:4.14E-9 ID:SGTC_2443|Compound:5493264|FD-Score:3.46|P-value:1.51E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.28|P-value:4.05E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.50|P-value:1.04E-38 ID:SGTC_2716|Compound:st080858|FD-Score:5.86|P-value:5.18E-10 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.54|P-value:1.23E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.22|P-value:5.40E-6 ID:SGTC_2920|Compound:7982904|FD-Score:3.66|P-value:6.57E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.64|P-value:6.40E-7 ID:SGTC_3216|Compound:9129716|FD-Score:-3.87|P-value:3.07E-5 ID:SGTC_3220|Compound:9131269|FD-Score:-3.55|P-value:1.18E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.38|P-value:2.47E-6 ID:SGTC_3253|Compound:9135987|FD-Score:3.90|P-value:2.32E-5

Top fitness defect scores for YGR208W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2679 rapamycin 12.50 1.0 nM 1.04E-38 13 6.88E-36
2 SGTC_18 0111-0177 12.10 500.0 nM 1.73E-36 4 7.82E-34
3 SGTC_1844 rapamycin 10.80 4.0 nM 1.25E-29 34 1.71E-27
4 SGTC_513 4245-1575 9.71 41.7 µM 2.56E-24 unfolded protein response 18 1.39E-22
5 SGTC_7 0192-1582 8.98 4.2 µM 4.31E-21 8 1.34E-19
6 SGTC_236 1509-0011 8.64 5.3 µM 1.20E-19 230 2.90E-18
7 SGTC_1242 0402-0103 8.01 60.1 µM 3.75E-17 3 5.88E-16
8 SGTC_386 1509-0011 6.88 3.1 µM 3.97E-13 79 3.09E-12
9 SGTC_159 3970-0959 6.22 50.0 µM 4.71E-11 22 2.56E-10
10 SGTC_2716 st080858 5.86 38.6 µM 5.18E-10 60S ribosome export 2 2.35E-9
11 SGTC_59 0330-0160 5.68 1.3 µM 1.60E-9 46 6.67E-9
12 SGTC_2406 ethylparaben 5.53 405.7 µM 4.14E-9 13 1.61E-8
13 SGTC_2336 9001819 5.14 198.7 µM 4.26E-8 heme biosynthesis & mitochondrial translocase 15 1.39E-7
14 SGTC_253 dyclonine 4.82 31.2 µM 2.55E-7 amide catabolism 10 7.26E-7
15 SGTC_2921 7974240 4.64 10.7 µM 6.40E-7 32 1.70E-6
16 SGTC_1388 3346-4487 4.54 254.0 µM 1.10E-6 10 2.82E-6
17 SGTC_2331 7980721 4.45 200.0 µM 1.78E-6 16 4.39E-6
18 SGTC_2337 9009472 4.43 200.0 µM 1.89E-6 19 4.65E-6
19 SGTC_3224 9130643 4.38 49.5 µM 2.47E-6 RPP1 & pyrimidine depletion 16 5.93E-6
20 SGTC_1129 3453-1384 4.37 223.0 µM 2.63E-6 29 6.29E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.404 1.06E-131 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.404 9.44E-132 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.363 1.75E-104 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.349 4.88E-96 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.330 4.45E-86 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.294 5.52E-68 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.285 1.10E-63 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.247 1.17E-47 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.233 1.72E-42 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.229 4.37E-41 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.225 1.29E-39 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.221 2.60E-38 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.219 1.01E-37 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.217 5.58E-37 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.213 1.00E-35 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway