YGR212W / SLI1

N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR212W / SLI1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.22|P-value:7.69E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.34|P-value:5.07E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.34|P-value:9.38E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.59|P-value:3.02E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:3.90|P-value:6.14E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:3.24|P-value:7.24E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.26|P-value:6.61E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:6.52|P-value:6.21E-11 ID:SGTC_867|Compound:0518-0118|FD-Score:4.09|P-value:2.85E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.66|P-value:1.56E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.47|P-value:3.20E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.74|P-value:1.15E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.47|P-value:3.18E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.67|P-value:1.51E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:40.40|P-value:0 ID:SGTC_2108|Compound:5365811|FD-Score:3.84|P-value:7.75E-5 ID:SGTC_2123|Compound:5259487|FD-Score:-3.61|P-value:1.56E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.21|P-value:8.05E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.81|P-value:8.69E-5 ID:SGTC_3098|Compound:9119039|FD-Score:4.34|P-value:9.26E-6 ID:SGTC_3173|Compound:9105693|FD-Score:4.31|P-value:1.06E-5 ID:SGTC_3188|Compound:9110789|FD-Score:3.24|P-value:7.14E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.45|P-value:3.39E-4 ID:SGTC_3262|Compound:9137218|FD-Score:-3.14|P-value:8.64E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.22|P-value:7.69E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.34|P-value:5.07E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.34|P-value:9.38E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.59|P-value:3.02E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:3.90|P-value:6.14E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:3.24|P-value:7.24E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.26|P-value:6.61E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:6.52|P-value:6.21E-11 ID:SGTC_867|Compound:0518-0118|FD-Score:4.09|P-value:2.85E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.66|P-value:1.56E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.47|P-value:3.20E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.74|P-value:1.15E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.47|P-value:3.18E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.67|P-value:1.51E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:40.40|P-value:0 ID:SGTC_2108|Compound:5365811|FD-Score:3.84|P-value:7.75E-5 ID:SGTC_2123|Compound:5259487|FD-Score:-3.61|P-value:1.56E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.21|P-value:8.05E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.81|P-value:8.69E-5 ID:SGTC_3098|Compound:9119039|FD-Score:4.34|P-value:9.26E-6 ID:SGTC_3173|Compound:9105693|FD-Score:4.31|P-value:1.06E-5 ID:SGTC_3188|Compound:9110789|FD-Score:3.24|P-value:7.14E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.45|P-value:3.39E-4 ID:SGTC_3262|Compound:9137218|FD-Score:-3.14|P-value:8.64E-4

Top fitness defect scores for YGR212W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1876 myriocin 40.40 605.0 nM 0 1 0
2 SGTC_864 0469-0573 6.52 172.0 µM 6.21E-11 1 3.63E-11
3 SGTC_421 streptovitacin 4.59 30.0 mM 3.02E-6 13 2.22E-6
4 SGTC_3098 9119039 4.34 49.5 µM 9.26E-6 Golgi 28 6.98E-6
5 SGTC_159 3970-0959 4.34 50.0 µM 9.38E-6 61 7.07E-6
6 SGTC_3173 9105693 4.31 49.5 µM 1.06E-5 12 8.03E-6
7 SGTC_867 0518-0118 4.09 155.0 µM 2.85E-5 DNA intercalators 18 2.20E-5
8 SGTC_424 splitomicin 3.90 100.0 mM 6.14E-5 23 4.83E-5
9 SGTC_2108 5365811 3.84 200.0 µM 7.75E-5 14 6.12E-5
10 SGTC_2787 5284540 3.81 71.4 µM 8.69E-5 28 6.89E-5
11 SGTC_1371 2421-0008 3.74 32.7 µM 1.15E-4 mitochondrial processes 48 9.19E-5
12 SGTC_1780 st038448 3.67 24.5 µM 1.51E-4 iron homeostasis 30 1.21E-4
13 SGTC_998 3996-0085 3.66 177.0 µM 1.56E-4 31 1.25E-4
14 SGTC_1774 st048371 3.47 48.5 µM 3.18E-4 RNA processing & uracil transport 36 2.59E-4
15 SGTC_1285 0929-0069 3.47 65.5 µM 3.20E-4 37 2.61E-4
16 SGTC_3191 9110352 3.45 49.5 µM 3.39E-4 24 2.77E-4
17 SGTC_46 0329-0187a 3.34 2.2 µM 5.07E-4 101 4.19E-4
18 SGTC_857 0438-0306 3.26 1.4 µM 6.61E-4 copper-dependent oxidative stress 28 5.49E-4
19 SGTC_3188 9110789 3.24 49.5 µM 7.14E-4 iron homeostasis 54 5.93E-4
20 SGTC_848 0368-0089 3.24 85.6 µM 7.24E-4 iron homeostasis 35 6.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.554 2.13E-269 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.474 2.03E-187 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.449 3.31E-166 YDR071C PAA1 hom Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
0.366 1.01E-106 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.259 1.08E-52 YJL213W YJL213W hom Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
0.243 2.96E-46 YHR041C SRB2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
0.230 1.35E-41 YHR059W FYV4 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.218 1.62E-37 YDR062W LCB2 het Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.209 1.79E-34 YER130C_p YER130C_p hom Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress
0.201 4.92E-32 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.184 6.71E-27 YGR139W_d YGR139W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.181 5.19E-26 YGR104C SRB5 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance
0.178 2.37E-25 YHR046C INM1 hom Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
0.175 1.37E-24 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.162 4.53E-21 YFR022W ROG3 hom Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication