YGR215W / RSM27

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR215W / RSM27

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.66|P-value:3.94E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.49|P-value:8.17E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.73|P-value:1.70E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.30|P-value:1.84E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:6.18|P-value:1.55E-9 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.12|P-value:4.19E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.37|P-value:6.14E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.83|P-value:1.33E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:13.80|P-value:4.55E-40 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.35|P-value:5.85E-16 ID:SGTC_310|Compound:1273-0058|FD-Score:10.80|P-value:1.72E-25 ID:SGTC_314|Compound:1671-0008|FD-Score:3.67|P-value:2.11E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.32|P-value:1.84E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.32|P-value:1.85E-7 ID:SGTC_596|Compound:1155-0152|FD-Score:3.96|P-value:7.34E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:8.16|P-value:2.55E-15 ID:SGTC_608|Compound:k048-0125|FD-Score:-3.69|P-value:2.09E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-4.64|P-value:4.50E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:3.66|P-value:2.24E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-4.50|P-value:8.42E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:-7.41|P-value:6.97E-13 ID:SGTC_676|Compound:falcarinol|FD-Score:3.94|P-value:7.92E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:3.31|P-value:7.38E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:5.23|P-value:2.56E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:3.97|P-value:6.91E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.73|P-value:1.70E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.80|P-value:1.34E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.96|P-value:7.18E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.04|P-value:5.34E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.44|P-value:1.03E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.32|P-value:7.11E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.25|P-value:9.05E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.13|P-value:4.20E-7 ID:SGTC_1624|Compound:st003710|FD-Score:4.87|P-value:1.46E-6 ID:SGTC_1656|Compound:st012921|FD-Score:-3.65|P-value:2.45E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.28|P-value:8.76E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.41|P-value:5.53E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.25|P-value:2.65E-7 ID:SGTC_1731|Compound:st035964|FD-Score:-4.39|P-value:1.36E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.26|P-value:2.13E-5 ID:SGTC_1774|Compound:st048371|FD-Score:-3.52|P-value:3.86E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.24|P-value:2.52E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.50|P-value:3.94E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.30|P-value:8.20E-4 ID:SGTC_1882|Compound:5615643|FD-Score:6.88|P-value:2.15E-11 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:6.07|P-value:2.93E-9 ID:SGTC_1884|Compound:5633444|FD-Score:-7.99|P-value:1.09E-14 ID:SGTC_1994|Compound:st072947|FD-Score:-4.11|P-value:4.34E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.77|P-value:1.47E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.49|P-value:3.96E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.53|P-value:5.72E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.08|P-value:4.46E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.04|P-value:5.17E-5 ID:SGTC_2310|Compound:7668677|FD-Score:4.16|P-value:3.33E-5 ID:SGTC_2526|Compound:patulin|FD-Score:5.52|P-value:6.05E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.68|P-value:7.57E-11 ID:SGTC_2705|Compound:st078069|FD-Score:-3.30|P-value:8.18E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.34|P-value:6.76E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.96|P-value:1.04E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.88|P-value:1.04E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-4.35|P-value:1.59E-5 ID:SGTC_2826|Compound:7992541|FD-Score:4.29|P-value:1.92E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.53|P-value:3.56E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.90|P-value:8.62E-9 ID:SGTC_2942|Compound:9052777|FD-Score:4.48|P-value:8.75E-6 ID:SGTC_3067|Compound:9117431|FD-Score:3.46|P-value:4.44E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-3.55|P-value:3.53E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-4.05|P-value:5.51E-5 ID:SGTC_3190|Compound:9110366|FD-Score:3.55|P-value:3.24E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-5.45|P-value:9.27E-8 ID:SGTC_3266|Compound:9136860|FD-Score:-4.28|P-value:2.17E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.66|P-value:3.94E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.49|P-value:8.17E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.73|P-value:1.70E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.30|P-value:1.84E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:6.18|P-value:1.55E-9 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.12|P-value:4.19E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.37|P-value:6.14E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.83|P-value:1.33E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:13.80|P-value:4.55E-40 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.35|P-value:5.85E-16 ID:SGTC_310|Compound:1273-0058|FD-Score:10.80|P-value:1.72E-25 ID:SGTC_314|Compound:1671-0008|FD-Score:3.67|P-value:2.11E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.32|P-value:1.84E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.32|P-value:1.85E-7 ID:SGTC_596|Compound:1155-0152|FD-Score:3.96|P-value:7.34E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:8.16|P-value:2.55E-15 ID:SGTC_608|Compound:k048-0125|FD-Score:-3.69|P-value:2.09E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-4.64|P-value:4.50E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:3.66|P-value:2.24E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-4.50|P-value:8.42E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:-7.41|P-value:6.97E-13 ID:SGTC_676|Compound:falcarinol|FD-Score:3.94|P-value:7.92E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:3.31|P-value:7.38E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:5.23|P-value:2.56E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:3.97|P-value:6.91E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.73|P-value:1.70E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.80|P-value:1.34E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.96|P-value:7.18E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.04|P-value:5.34E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.44|P-value:1.03E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.32|P-value:7.11E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.25|P-value:9.05E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.13|P-value:4.20E-7 ID:SGTC_1624|Compound:st003710|FD-Score:4.87|P-value:1.46E-6 ID:SGTC_1656|Compound:st012921|FD-Score:-3.65|P-value:2.45E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.28|P-value:8.76E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.41|P-value:5.53E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.25|P-value:2.65E-7 ID:SGTC_1731|Compound:st035964|FD-Score:-4.39|P-value:1.36E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.26|P-value:2.13E-5 ID:SGTC_1774|Compound:st048371|FD-Score:-3.52|P-value:3.86E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.24|P-value:2.52E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.50|P-value:3.94E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.30|P-value:8.20E-4 ID:SGTC_1882|Compound:5615643|FD-Score:6.88|P-value:2.15E-11 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:6.07|P-value:2.93E-9 ID:SGTC_1884|Compound:5633444|FD-Score:-7.99|P-value:1.09E-14 ID:SGTC_1994|Compound:st072947|FD-Score:-4.11|P-value:4.34E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.77|P-value:1.47E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.49|P-value:3.96E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.53|P-value:5.72E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.08|P-value:4.46E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.04|P-value:5.17E-5 ID:SGTC_2310|Compound:7668677|FD-Score:4.16|P-value:3.33E-5 ID:SGTC_2526|Compound:patulin|FD-Score:5.52|P-value:6.05E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.68|P-value:7.57E-11 ID:SGTC_2705|Compound:st078069|FD-Score:-3.30|P-value:8.18E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.34|P-value:6.76E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.96|P-value:1.04E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.88|P-value:1.04E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-4.35|P-value:1.59E-5 ID:SGTC_2826|Compound:7992541|FD-Score:4.29|P-value:1.92E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.53|P-value:3.56E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.90|P-value:8.62E-9 ID:SGTC_2942|Compound:9052777|FD-Score:4.48|P-value:8.75E-6 ID:SGTC_3067|Compound:9117431|FD-Score:3.46|P-value:4.44E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-3.55|P-value:3.53E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-4.05|P-value:5.51E-5 ID:SGTC_3190|Compound:9110366|FD-Score:3.55|P-value:3.24E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-5.45|P-value:9.27E-8 ID:SGTC_3266|Compound:9136860|FD-Score:-4.28|P-value:2.17E-5

Top fitness defect scores for YGR215W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 13.80 5.3 µM 4.55E-40 121 1.90E-43
2 SGTC_310 1273-0058 10.80 1.1 µM 1.72E-25 mitochondrial stress 32 1.42E-27
3 SGTC_173 1273-0061 8.83 2.7 µM 1.33E-17 mitochondrial stress 53 5.47E-19
4 SGTC_275 trichlorophene 8.35 5.7 µM 5.85E-16 mitochondrial stress 66 3.35E-17
5 SGTC_601 0986-0029 8.16 62.9 µM 2.55E-15 calcium & mitochondrial duress 4 1.66E-16
6 SGTC_1882 5615643 6.88 20.0 µM 2.15E-11 TRP & mitochondrial translation 13 3.08E-12
7 SGTC_2688 kanamycin b 6.68 96.7 µM 7.57E-11 calcium & mitochondrial duress 119 1.21E-11
8 SGTC_70 0141-0289 6.18 43.3 µM 1.55E-9 mitochondrial stress 76 3.22E-10
9 SGTC_1883 5-benzylidenerhodanine 6.07 20.0 µM 2.93E-9 TRP & mitochondrial translation 18 6.44E-10
10 SGTC_2232 chlorophetanol 5.53 41.5 µM 5.72E-8 TRP & mitochondrial translation 53 1.63E-8
11 SGTC_2526 patulin 5.52 37.6 µM 6.05E-8 34 1.73E-8
12 SGTC_767 0929-0023 5.23 86.0 µM 2.56E-7 TRP & mitochondrial translation 29 8.26E-8
13 SGTC_1623 st003709 5.13 20.3 µM 4.20E-7 calcium & mitochondrial duress 26 1.42E-7
14 SGTC_1624 st003710 4.87 6.2 µM 1.46E-6 calcium & mitochondrial duress 24 5.48E-7
15 SGTC_10 0279-0212 4.66 42.6 µM 3.94E-6 TRP & mitochondrial translation 78 1.61E-6
16 SGTC_28 pentachloropyridine N-oxide 4.49 1.6 µM 8.17E-6 TSC3-RPN4 46 3.54E-6
17 SGTC_2942 9052777 4.48 62.2 µM 8.75E-6 21 3.82E-6
18 SGTC_1353 1498-1206 4.44 8.1 µM 1.03E-5 mitochondrial response to ROS 40 4.55E-6
19 SGTC_68 0986-0284 4.30 82.8 µM 1.84E-5 51 8.55E-6
20 SGTC_2826 7992541 4.29 19.5 µM 1.92E-5 15 8.96E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.522 7.44E-234 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.516 3.85E-227 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.516 2.38E-227 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.502 4.39E-214 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.498 5.48E-210 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.497 6.44E-209 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.491 3.65E-203 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.487 1.96E-199 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.483 8.01E-196 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.474 4.96E-188 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.474 1.41E-187 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.474 3.33E-187 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.473 7.94E-187 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.470 2.13E-184 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.470 3.91E-184 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit