YGR216C / GPI1

Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR216C / GPI1

Click on Significant Values for Screen Details ID:SGTC_289|Compound:k017-0060|FD-Score:-2.70|P-value:4.42E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:2.60|P-value:4.86E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.32|P-value:2.03E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:2.50|P-value:7.47E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.54|P-value:6.00E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:-2.93|P-value:1.55E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.28|P-value:1.67E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:-2.68|P-value:4.93E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.14|P-value:5.38E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.17|P-value:4.69E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.76|P-value:3.38E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.07|P-value:4.99E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:2.61|P-value:4.59E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.61|P-value:4.64E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.09|P-value:6.78E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.97|P-value:3.66E-10 ID:SGTC_1120|Compound:ficusin|FD-Score:-2.98|P-value:1.19E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-2.98|P-value:1.21E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-2.61|P-value:6.74E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-2.90|P-value:1.77E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.71|P-value:2.87E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:2.86|P-value:1.47E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.67|P-value:3.53E-9 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.46|P-value:8.90E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.88|P-value:1.32E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:2.71|P-value:2.95E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.56|P-value:8.04E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:-2.81|P-value:2.73E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-2.69|P-value:4.73E-4 ID:SGTC_1686|Compound:st019653|FD-Score:2.92|P-value:1.07E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-2.61|P-value:6.51E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.25|P-value:7.07E-8 ID:SGTC_1904|Compound:st060225|FD-Score:-2.67|P-value:5.14E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.45|P-value:9.23E-4 ID:SGTC_2234|Compound:tolnaftate|FD-Score:-2.81|P-value:2.65E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.05|P-value:8.25E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.99|P-value:4.03E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-2.58|P-value:7.49E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.10|P-value:6.56E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.61|P-value:4.54E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.79|P-value:2.95E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.16|P-value:4.85E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:2.48|P-value:8.18E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.76|P-value:3.32E-4 ID:SGTC_2918|Compound:7977171|FD-Score:2.47|P-value:8.62E-4 ID:SGTC_2965|Compound:9082772|FD-Score:2.79|P-value:1.98E-4 ID:SGTC_2967|Compound:9089538|FD-Score:6.36|P-value:6.28E-16 ID:SGTC_2970|Compound:9090938|FD-Score:2.70|P-value:3.09E-4 ID:SGTC_2973|Compound:9094665|FD-Score:6.17|P-value:4.06E-15 ID:SGTC_3002|Compound:9075603|FD-Score:-3.29|P-value:2.41E-5 ID:SGTC_289|Compound:k017-0060|FD-Score:-2.70|P-value:4.42E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:2.60|P-value:4.86E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.32|P-value:2.03E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:2.50|P-value:7.47E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.54|P-value:6.00E-6 ID:SGTC_755|Compound:1995-0008|FD-Score:-2.93|P-value:1.55E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.28|P-value:1.67E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:-2.68|P-value:4.93E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.14|P-value:5.38E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.17|P-value:4.69E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.76|P-value:3.38E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.07|P-value:4.99E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:2.61|P-value:4.59E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.61|P-value:4.64E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.09|P-value:6.78E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.97|P-value:3.66E-10 ID:SGTC_1120|Compound:ficusin|FD-Score:-2.98|P-value:1.19E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-2.98|P-value:1.21E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-2.61|P-value:6.74E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-2.90|P-value:1.77E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.71|P-value:2.87E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:2.86|P-value:1.47E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.67|P-value:3.53E-9 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.46|P-value:8.90E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.88|P-value:1.32E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:2.71|P-value:2.95E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.56|P-value:8.04E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:-2.81|P-value:2.73E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-2.69|P-value:4.73E-4 ID:SGTC_1686|Compound:st019653|FD-Score:2.92|P-value:1.07E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-2.61|P-value:6.51E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.25|P-value:7.07E-8 ID:SGTC_1904|Compound:st060225|FD-Score:-2.67|P-value:5.14E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.45|P-value:9.23E-4 ID:SGTC_2234|Compound:tolnaftate|FD-Score:-2.81|P-value:2.65E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.05|P-value:8.25E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.99|P-value:4.03E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-2.58|P-value:7.49E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.10|P-value:6.56E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.61|P-value:4.54E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.79|P-value:2.95E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.16|P-value:4.85E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:2.48|P-value:8.18E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.76|P-value:3.32E-4 ID:SGTC_2918|Compound:7977171|FD-Score:2.47|P-value:8.62E-4 ID:SGTC_2965|Compound:9082772|FD-Score:2.79|P-value:1.98E-4 ID:SGTC_2967|Compound:9089538|FD-Score:6.36|P-value:6.28E-16 ID:SGTC_2970|Compound:9090938|FD-Score:2.70|P-value:3.09E-4 ID:SGTC_2973|Compound:9094665|FD-Score:6.17|P-value:4.06E-15 ID:SGTC_3002|Compound:9075603|FD-Score:-3.29|P-value:2.41E-5

Top fitness defect scores for YGR216C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2967 9089538 6.36 49.9 µM 6.28E-16 2 1.01E-10 0.77
2 SGTC_2973 9094665 6.17 18.0 µM 4.06E-15 NEO1 6 3.35E-10 0.39
3 SGTC_763 3453-1109 3.28 128.0 µM 1.67E-5 11 5.20E-4 0.12
4 SGTC_916 4466-0038 3.07 42.0 nM 4.99E-5 cell wall 41 0.00106 0.04
5 SGTC_1686 st019653 2.92 115.5 µM 1.07E-4 mitochondrial processes 15 0.00175 0.01
6 SGTC_1370 2001-0092 2.88 44.6 µM 1.32E-4 16 0.00199 0.01
7 SGTC_1136 pergolide 2.86 1.1 µM 1.47E-4 38 0.00215 0.00
8 SGTC_2965 9082772 2.79 38.6 µM 1.98E-4 mitochondrial response to ROS 7 0.00260 0.06
9 SGTC_1135 dihydrocapsaicin 2.71 536.7 nM 2.87E-4 20 0.00332 0.05
10 SGTC_1403 3909-7815 2.71 62.9 µM 2.95E-4 15 0.00338 0.10
11 SGTC_2970 9090938 2.70 41.9 µM 3.09E-4 RNA processing & uracil transport 31 0.00348 0.00
12 SGTC_2583 asiatic acid 2.61 100.0 µM 4.54E-4 33 0.00448 0.06
13 SGTC_968 1309-0633 2.61 340.0 µM 4.59E-4 22 0.00451 0.03
14 SGTC_1008 4106-0037 2.61 6.0 µM 4.64E-4 PDR1 22 0.00454 0.00
15 SGTC_525 k781-2675 2.60 26.7 µM 4.86E-4 redox potentiating 71 0.00468 0.02
16 SGTC_535 2293-4129 2.50 48.2 µM 7.47E-4 NEO1 36 0.00620 0.03
17 SGTC_2688 kanamycin b 2.48 96.7 µM 8.18E-4 calcium & mitochondrial duress 60 0.00658 0.04
18 SGTC_2918 7977171 2.47 22.1 µM 8.62E-4 22 0.00681 0.04
19 SGTC_1230 0170-0365 2.46 3.8 µM 8.90E-4 endomembrane recycling 48 0.00696 0.05
20 SGTC_2160 5660466 2.45 132.9 µM 9.23E-4 60S ribosome export 38 0.00713 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 3.68E-43 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.211 3.77E-35 YML100W TSL1 hom Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
0.208 4.12E-34 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.199 3.57E-31 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.196 2.16E-30 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.193 1.71E-29 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.191 8.84E-29 YGR251W NOP19 het Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.186 1.21E-27 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.183 1.17E-26 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.183 1.39E-26 YKL141W SDH3 het Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
0.182 2.42E-26 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.181 4.20E-26 YMR149W SWP1 het Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
0.180 6.09E-26 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.174 3.10E-24 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.174 3.79E-24 YLR267W_p BOP2_p hom Protein of unknown function