YGR219W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR219W / YGR219W

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.69|P-value:1.00E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.69|P-value:4.00E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.64|P-value:1.39E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:3.51|P-value:6.97E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.05|P-value:1.13E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.47|P-value:2.35E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.75|P-value:3.01E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.47|P-value:3.12E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:12.70|P-value:4.66E-31 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.26|P-value:8.26E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:8.23|P-value:3.17E-14 ID:SGTC_314|Compound:1671-0008|FD-Score:5.31|P-value:6.84E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.12|P-value:8.38E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.46|P-value:2.27E-5 ID:SGTC_394|Compound:menadione|FD-Score:-4.42|P-value:2.62E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.71|P-value:3.40E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.62|P-value:4.64E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.41|P-value:8.99E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.39|P-value:9.71E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.81|P-value:2.66E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-4.25|P-value:5.08E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:5.65|P-value:1.36E-7 ID:SGTC_814|Compound:3342-0569|FD-Score:3.59|P-value:5.50E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:5.11|P-value:1.61E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.62|P-value:1.32E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.09|P-value:9.99E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.46|P-value:8.21E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:6.21|P-value:7.65E-9 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.56|P-value:1.70E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.62|P-value:4.69E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.50|P-value:6.75E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.40|P-value:9.38E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-4.56|P-value:1.52E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.25|P-value:8.09E-7 ID:SGTC_1922|Compound:5578187|FD-Score:3.45|P-value:8.65E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.81|P-value:2.64E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.75|P-value:3.28E-4 ID:SGTC_2158|Compound:5657123|FD-Score:-3.43|P-value:8.50E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.35|P-value:5.45E-7 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.63|P-value:4.89E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.95|P-value:1.66E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.53|P-value:6.68E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.78|P-value:2.75E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.42|P-value:9.36E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.56|P-value:5.54E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.43|P-value:8.37E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.69|P-value:1.00E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.69|P-value:4.00E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.64|P-value:1.39E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:3.51|P-value:6.97E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.05|P-value:1.13E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.47|P-value:2.35E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.75|P-value:3.01E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.47|P-value:3.12E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:12.70|P-value:4.66E-31 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.26|P-value:8.26E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:8.23|P-value:3.17E-14 ID:SGTC_314|Compound:1671-0008|FD-Score:5.31|P-value:6.84E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.12|P-value:8.38E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.46|P-value:2.27E-5 ID:SGTC_394|Compound:menadione|FD-Score:-4.42|P-value:2.62E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.71|P-value:3.40E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.62|P-value:4.64E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.41|P-value:8.99E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.39|P-value:9.71E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.81|P-value:2.66E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-4.25|P-value:5.08E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:5.65|P-value:1.36E-7 ID:SGTC_814|Compound:3342-0569|FD-Score:3.59|P-value:5.50E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:5.11|P-value:1.61E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.62|P-value:1.32E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.09|P-value:9.99E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.46|P-value:8.21E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:6.21|P-value:7.65E-9 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.56|P-value:1.70E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.62|P-value:4.69E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.50|P-value:6.75E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.40|P-value:9.38E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-4.56|P-value:1.52E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.25|P-value:8.09E-7 ID:SGTC_1922|Compound:5578187|FD-Score:3.45|P-value:8.65E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.81|P-value:2.64E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.75|P-value:3.28E-4 ID:SGTC_2158|Compound:5657123|FD-Score:-3.43|P-value:8.50E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.35|P-value:5.45E-7 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.63|P-value:4.89E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.95|P-value:1.66E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.53|P-value:6.68E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.78|P-value:2.75E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.42|P-value:9.36E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.56|P-value:5.54E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.43|P-value:8.37E-4

Top fitness defect scores for YGR219W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 12.70 5.3 µM 4.66E-31 136 5.55E-37
2 SGTC_310 1273-0058 8.23 1.1 µM 3.17E-14 mitochondrial stress 82 9.08E-17
3 SGTC_1057 3448-5381 6.21 134.0 µM 7.65E-9 calcium & mitochondrial duress 7 2.59E-10
4 SGTC_782 0083-0095 5.65 30.5 µM 1.36E-7 5 8.11E-9
5 SGTC_63 0099-0242 5.64 26.7 µM 1.39E-7 mitochondrial stress 33 8.33E-9
6 SGTC_173 1273-0061 5.47 2.7 µM 3.12E-7 mitochondrial stress 125 2.19E-8
7 SGTC_2232 chlorophetanol 5.35 41.5 µM 5.45E-7 TRP & mitochondrial translation 63 4.29E-8
8 SGTC_314 1671-0008 5.31 2.7 µM 6.84E-7 15 5.62E-8
9 SGTC_275 trichlorophene 5.26 5.7 µM 8.26E-7 mitochondrial stress 153 7.05E-8
10 SGTC_820 1582-0060 5.11 59.9 µM 1.61E-6 10 1.57E-7
11 SGTC_10 0279-0212 4.69 42.6 µM 1.00E-5 TRP & mitochondrial translation 76 1.39E-6
12 SGTC_831 k061-1017 4.62 217.0 µM 1.32E-5 translation 31 1.95E-6
13 SGTC_1274 0865-0114 4.56 173.0 µM 1.70E-5 11 2.62E-6
14 SGTC_119 0121-0043 4.47 24.8 µM 2.35E-5 mitochondrial stress 77 3.86E-6
15 SGTC_832 4083-0019 4.09 164.0 µM 9.99E-5 translation 87 2.17E-5
16 SGTC_118 0083-0097 4.05 135.3 µM 1.13E-4 translation 123 2.52E-5
17 SGTC_2333 9017922 3.95 200.0 µM 1.66E-4 25 3.98E-5
18 SGTC_2144 5628481 3.81 200.0 µM 2.64E-4 ERG2 26 6.94E-5
19 SGTC_614 0462-0418 3.81 107.0 µM 2.66E-4 32 7.00E-5
20 SGTC_2154 5570129 3.75 200.0 µM 3.28E-4 21 8.99E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.497 1.11E-207 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.441 1.09E-159 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.440 1.90E-158 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.440 8.46E-159 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.433 4.09E-153 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.432 2.25E-152 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.429 4.72E-150 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.427 3.02E-148 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.426 6.94E-148 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.426 8.33E-148 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.425 2.19E-147 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.425 4.98E-147 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.423 5.45E-146 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.413 2.32E-138 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.406 3.15E-133 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation