HIPHOP chemogenomics database

YGR229C / SMI1

Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR229C / SMI1

Click on Significant Values for Screen Details

Top fitness defect scores for YGR229C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2289	7946404	8.34	165.1 µM	6.14E-15		13	3.63E-17
2	SGTC_206	4546-0025	8.26	72.0 µM	1.13E-14	NEO1	19	7.38E-17
3	SGTC_759	3486-0358	7.56	89.3 µM	1.48E-12		1	2.07E-14
4	SGTC_137	0438-0332	7.32	85.4 µM	7.00E-12	ubiquinone biosynthesis & proteasome	45	1.25E-13
5	SGTC_1105	epirubicin	7.05	18.1 µM	3.81E-11	anthracycline transcription coupled DNA repair	2	8.86E-13
6	SGTC_2585	alliin	6.23	100.0 µM	4.63E-9		4	2.29E-10
7	SGTC_2146	5545642	6.21	200.0 µM	5.27E-9		2	2.66E-10
8	SGTC_59	0330-0160	5.29	1.3 µM	5.89E-7		52	6.27E-8
9	SGTC_887	0885-0007	5.24	9.6 µM	7.16E-7	endomembrane recycling	20	7.88E-8
10	SGTC_685	1278-0033	5.22	54.9 µM	8.11E-7	60S ribosome export	5	9.09E-8
11	SGTC_3113	9123498	5.17	49.5 µM	9.85E-7		3	1.14E-7
12	SGTC_2254	7938975	5.12	95.2 µM	1.27E-6		30	1.53E-7
13	SGTC_67	0335-0847	5.10	266.0 µM	1.37E-6	ubiquinone biosynthesis & proteasome	84	1.67E-7
14	SGTC_715	0868-0130	5.02	184.0 µM	2.01E-6		6	2.61E-7
15	SGTC_91	0417-1751	5.01	58.4 µM	2.08E-6	Golgi	24	2.71E-7
16	SGTC_142	0335-0849	4.98	62.7 µM	2.35E-6	ubiquinone biosynthesis & proteasome	84	3.12E-7
17	SGTC_90	0870-0863	4.93	4.6 µM	2.92E-6		23	4.02E-7
18	SGTC_58	0957-0393	4.86	9.0 µM	4.00E-6	cell wall	299	5.79E-7
19	SGTC_706	4262-0057	4.80	46.9 µM	5.32E-6	fatty acid desaturase (OLE1)	13	8.06E-7
20	SGTC_270	tamoxifen	4.69	5.5 µM	8.26E-6	NEO1	14	1.34E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.170	3.88E-23	YJL193W_p	YJL193W_p	hom	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.147	1.12E-17	YMR316W	DIA1	hom	Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.140	4.40E-16	YJL155C	FBP26	hom	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.139	6.03E-16	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.131	2.41E-14	YDR086C	SSS1	het	Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.129	5.93E-14	YCR094W	CDC50	hom	Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.127	1.68E-13	YJR073C	OPI3	hom	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
0.121	1.89E-12	YOR165W	SEY1	hom	Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.121	2.36E-12	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121	2.36E-12	YDR363W-A	SEM1	hom	Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress
0.116	1.63E-11	YBR275C	RIF1	hom	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.115	2.46E-11	YJL168C	SET2	hom	Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.114	3.59E-11	YPR146C_d	YPR146C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114	4.22E-11	YMR110C	HFD1	hom	Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.113	6.06E-11	YJR118C	ILM1	hom	Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth