YGR232W / NAS6

Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR232W / NAS6

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.86|P-value:9.58E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.19|P-value:8.69E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:3.88|P-value:7.11E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.53|P-value:2.64E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:5.93|P-value:2.97E-9 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.62|P-value:1.91E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.72|P-value:1.35E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.36|P-value:4.97E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.10|P-value:2.91E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.36|P-value:4.90E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.20|P-value:8.52E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:6.83|P-value:1.07E-11 ID:SGTC_935|Compound:2996-0153|FD-Score:4.06|P-value:3.47E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.50|P-value:5.07E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.24|P-value:7.50E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.19|P-value:8.82E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.43|P-value:3.86E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.17|P-value:9.33E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.22|P-value:7.85E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.83|P-value:8.50E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.63|P-value:1.89E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.93|P-value:6.57E-7 ID:SGTC_1728|Compound:st035614|FD-Score:3.20|P-value:8.47E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.89|P-value:6.90E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.76|P-value:1.14E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.20|P-value:8.60E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.76|P-value:1.15E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.29|P-value:1.32E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.55|P-value:2.47E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.18|P-value:9.20E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.82|P-value:8.86E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-3.28|P-value:6.53E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.15|P-value:2.38E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.22|P-value:7.87E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.29|P-value:6.20E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.41|P-value:4.10E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.92|P-value:5.92E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.64|P-value:1.78E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.80|P-value:9.66E-5 ID:SGTC_2878|Compound:9043973|FD-Score:3.33|P-value:5.51E-4 ID:SGTC_2945|Compound:9067681|FD-Score:6.31|P-value:3.15E-10 ID:SGTC_2946|Compound:9065502|FD-Score:3.21|P-value:8.26E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.52|P-value:4.60E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-3.17|P-value:9.33E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.70|P-value:1.40E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.86|P-value:9.58E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.19|P-value:8.69E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:3.88|P-value:7.11E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.53|P-value:2.64E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:5.93|P-value:2.97E-9 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.62|P-value:1.91E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.72|P-value:1.35E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.36|P-value:4.97E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.10|P-value:2.91E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.36|P-value:4.90E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.20|P-value:8.52E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:6.83|P-value:1.07E-11 ID:SGTC_935|Compound:2996-0153|FD-Score:4.06|P-value:3.47E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.50|P-value:5.07E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.24|P-value:7.50E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.19|P-value:8.82E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.43|P-value:3.86E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.17|P-value:9.33E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.22|P-value:7.85E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.83|P-value:8.50E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.63|P-value:1.89E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.93|P-value:6.57E-7 ID:SGTC_1728|Compound:st035614|FD-Score:3.20|P-value:8.47E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.89|P-value:6.90E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.76|P-value:1.14E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.20|P-value:8.60E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.76|P-value:1.15E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.29|P-value:1.32E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.55|P-value:2.47E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.18|P-value:9.20E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.82|P-value:8.86E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-3.28|P-value:6.53E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.15|P-value:2.38E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.22|P-value:7.87E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.29|P-value:6.20E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.41|P-value:4.10E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.92|P-value:5.92E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.64|P-value:1.78E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.80|P-value:9.66E-5 ID:SGTC_2878|Compound:9043973|FD-Score:3.33|P-value:5.51E-4 ID:SGTC_2945|Compound:9067681|FD-Score:6.31|P-value:3.15E-10 ID:SGTC_2946|Compound:9065502|FD-Score:3.21|P-value:8.26E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.52|P-value:4.60E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-3.17|P-value:9.33E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.70|P-value:1.40E-4

Top fitness defect scores for YGR232W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_932 2857-0803 6.83 154.0 µM 1.07E-11 4 4.26E-12
2 SGTC_2945 9067681 6.31 61.8 µM 3.15E-10 4 1.43E-10
3 SGTC_378 3970-0959 5.93 8.3 µM 2.97E-9 2 1.48E-9
4 SGTC_1454 4239-0054 4.93 42.6 µM 6.57E-7 11 4.03E-7
5 SGTC_6 0844-0013 4.86 19.8 µM 9.58E-7 42 5.96E-7
6 SGTC_2950 9072895 4.52 21.5 µM 4.60E-6 23 3.04E-6
7 SGTC_940 3232-1287 4.50 54.8 µM 5.07E-6 NEO1 22 3.36E-6
8 SGTC_1936 st074407 4.29 74.3 µM 1.32E-5 DNA damage response 24 9.11E-6
9 SGTC_2330 7979373 4.15 200.0 µM 2.38E-5 60S ribosome export 31 1.67E-5
10 SGTC_704 1310-0270 4.10 142.0 µM 2.91E-5 31 2.06E-5
11 SGTC_935 2996-0153 4.06 430.0 µM 3.47E-5 PDR1 18 2.48E-5
12 SGTC_328 k915-0120 3.88 63.5 µM 7.11E-5 TSC3-RPN4 23 5.22E-5
13 SGTC_1342 1486-1464 3.83 234.0 µM 8.50E-5 19 6.28E-5
14 SGTC_2183 6420625 3.82 130.5 µM 8.86E-5 mitochondrial processes 64 6.55E-5
15 SGTC_2865 9030313 3.80 52.0 µM 9.66E-5 15 7.17E-5
16 SGTC_1785 bathophenanthroline 3.76 24.0 µM 1.14E-4 heme requiring 58 8.51E-5
17 SGTC_1868 st057644 3.76 42.7 µM 1.15E-4 43 8.63E-5
18 SGTC_669 0108-0021 3.72 26.2 µM 1.35E-4 fatty acid desaturase (OLE1) 93 1.01E-4
19 SGTC_2792 7535235 3.71 81.8 µM 1.37E-4 fatty acid desaturase (OLE1) 41 1.03E-4
20 SGTC_2786 7743617 3.64 45.5 µM 1.78E-4 36 1.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.67E-10 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.103 2.50E-9 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.094 5.49E-8 YLR458W_d YLR458W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
0.090 1.66E-7 YNR071C_p YNR071C_p hom Putative aldose 1-epimerase
0.089 2.49E-7 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.087 4.04E-7 YBL106C SRO77 hom Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
0.085 7.82E-7 YNL065W AQR1 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.085 9.28E-7 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.084 1.07E-6 YMR226C YMR226C hom NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
0.082 2.01E-6 YIL009C-A EST3 hom Component of the telomerase holoenzyme, involved in telomere replication
0.082 2.06E-6 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.080 3.23E-6 YJL211C_d YJL211C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
0.079 4.73E-6 YNR009W NRM1 hom Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
0.079 4.86E-6 YBR107C IML3 hom Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1
0.078 6.15E-6 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31