YGR234W / YHB1

Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR234W / YHB1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.28|P-value:7.83E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.60|P-value:2.61E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:3.00|P-value:3.85E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:2.83|P-value:7.56E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.14|P-value:2.15E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.39|P-value:6.96E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.37|P-value:7.88E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.27|P-value:1.16E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.47|P-value:5.09E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.16|P-value:2.02E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.13|P-value:2.23E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:2.81|P-value:8.07E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.53|P-value:3.84E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.76|P-value:1.14E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.12|P-value:2.23E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-2.93|P-value:4.96E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:2.86|P-value:6.67E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:-2.75|P-value:9.81E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.03|P-value:3.44E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.08|P-value:2.37E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:-5.59|P-value:1.66E-10 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.36|P-value:7.68E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:2.77|P-value:9.71E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-2.79|P-value:8.51E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.07|P-value:2.87E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.00|P-value:3.82E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.57|P-value:2.89E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.73|P-value:5.78E-8 ID:SGTC_1636|Compound:st007707|FD-Score:3.38|P-value:7.71E-5 ID:SGTC_1673|Compound:st016611|FD-Score:2.94|P-value:4.85E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.43|P-value:3.40E-7 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:2.78|P-value:9.33E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.76|P-value:1.24E-5 ID:SGTC_2073|Compound:5212005|FD-Score:2.91|P-value:5.59E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.16|P-value:1.58E-6 ID:SGTC_2196|Compound:6573537|FD-Score:2.96|P-value:4.50E-4 ID:SGTC_2219|Compound:9098279|FD-Score:2.82|P-value:7.81E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-2.98|P-value:3.99E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.02|P-value:3.64E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.23|P-value:1.39E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-2.91|P-value:5.20E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.94|P-value:4.66E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.77|P-value:9.02E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.34|P-value:5.60E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.85|P-value:7.50E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.40|P-value:7.00E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:-2.97|P-value:4.22E-4 ID:SGTC_3155|Compound:9099265|FD-Score:2.76|P-value:9.82E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.28|P-value:7.83E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.60|P-value:2.61E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:3.00|P-value:3.85E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:2.83|P-value:7.56E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.14|P-value:2.15E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.39|P-value:6.96E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.37|P-value:7.88E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.27|P-value:1.16E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.47|P-value:5.09E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.16|P-value:2.02E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.13|P-value:2.23E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:2.81|P-value:8.07E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.53|P-value:3.84E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.76|P-value:1.14E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.12|P-value:2.23E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-2.93|P-value:4.96E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:2.86|P-value:6.67E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:-2.75|P-value:9.81E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.03|P-value:3.44E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.08|P-value:2.37E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:-5.59|P-value:1.66E-10 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.36|P-value:7.68E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:2.77|P-value:9.71E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-2.79|P-value:8.51E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.07|P-value:2.87E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.00|P-value:3.82E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.57|P-value:2.89E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.73|P-value:5.78E-8 ID:SGTC_1636|Compound:st007707|FD-Score:3.38|P-value:7.71E-5 ID:SGTC_1673|Compound:st016611|FD-Score:2.94|P-value:4.85E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.43|P-value:3.40E-7 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:2.78|P-value:9.33E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.76|P-value:1.24E-5 ID:SGTC_2073|Compound:5212005|FD-Score:2.91|P-value:5.59E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.16|P-value:1.58E-6 ID:SGTC_2196|Compound:6573537|FD-Score:2.96|P-value:4.50E-4 ID:SGTC_2219|Compound:9098279|FD-Score:2.82|P-value:7.81E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-2.98|P-value:3.99E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.02|P-value:3.64E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.23|P-value:1.39E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-2.91|P-value:5.20E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.94|P-value:4.66E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.77|P-value:9.02E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.34|P-value:5.60E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.85|P-value:7.50E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.40|P-value:7.00E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:-2.97|P-value:4.22E-4 ID:SGTC_3155|Compound:9099265|FD-Score:2.76|P-value:9.82E-4

Top fitness defect scores for YGR234W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1631 benzylvanillin 4.73 81.9 µM 5.78E-8 Golgi 13 1.14E-6
2 SGTC_1679 4130-1276 4.43 6.7 µM 3.40E-7 Golgi 49 4.72E-6
3 SGTC_2573 2',4'-dihydroxychalcone 4.34 15.0 µM 5.60E-7 35 7.04E-6
4 SGTC_65 0798-0905 4.28 35.0 µM 7.83E-7 calcium & mitochondrial duress 74 9.20E-6
5 SGTC_2078 5212016 4.16 200.0 µM 1.58E-6 60S ribosome export 13 1.62E-5
6 SGTC_1241 0364-0022 4.08 50.8 µM 2.37E-6 ERG2 26 2.23E-5
7 SGTC_1973 st070275 3.76 50.2 µM 1.24E-5 12 8.47E-5
8 SGTC_912 3474-0017 3.53 2.2 µM 3.84E-5 36 2.10E-4
9 SGTC_407 eburnamonine 3.47 100.0 µM 5.09E-5 26 2.63E-4
10 SGTC_2594 a-mangostin 3.40 100.0 µM 7.00E-5 54 3.39E-4
11 SGTC_1636 st007707 3.38 68.9 µM 7.71E-5 69 3.67E-4
12 SGTC_368 fentichlor 3.37 4.6 µM 7.88E-5 43 3.74E-4
13 SGTC_604 1000-0114 3.16 314.0 µM 2.02E-4 58 7.98E-4
14 SGTC_355 1311-2252 3.14 105.0 µM 2.15E-4 57 8.37E-4
15 SGTC_622 1348-1566 3.13 26.3 µM 2.23E-4 52 8.65E-4
16 SGTC_1388 3346-4487 3.07 254.0 µM 2.87E-4 59 0.00106
17 SGTC_1166 k206-0078 3.03 225.0 µM 3.44E-4 57 0.00122
18 SGTC_2310 7668677 3.02 200.0 µM 3.64E-4 91 0.00128
19 SGTC_1599 8-chlro-1-tetrahydronorharmanone 3.00 90.6 µM 3.82E-4 82 0.00133
20 SGTC_180 1486-1293 3.00 102.8 µM 3.85E-4 84 0.00134

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 6.31E-17 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.130 4.10E-14 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.124 6.64E-13 YMR297W PRC1 hom Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
0.122 1.19E-12 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.116 1.83E-11 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.116 1.96E-11 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.112 8.94E-11 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.108 3.05E-10 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.106 7.20E-10 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.103 1.96E-9 YGL170C SPO74 hom Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
0.099 9.17E-9 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.096 2.46E-8 YMR002W MIC17 hom Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.096 2.90E-8 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.096 3.03E-8 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.094 4.76E-8 YBR148W YSW1 hom Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane