HIPHOP chemogenomics database

YGR237C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR237C / YGR237C

Click on Significant Values for Screen Details

Top fitness defect scores for YGR237C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2688	kanamycin b	9.46	96.7 µM	5.72E-22	calcium & mitochondrial duress	35	1.56E-21
2	SGTC_528	3492-0019	8.89	172.0 µM	1.25E-19	calcium & mitochondrial duress	55	3.09E-19
3	SGTC_1712	st032288	5.72	53.4 µM	3.47E-9	calcium & mitochondrial duress	85	5.32E-9
4	SGTC_3104	9120930	5.16	49.5 µM	8.61E-8		2	1.24E-7
5	SGTC_2804	7954240	5.02	19.5 µM	1.78E-7		10	2.53E-7
6	SGTC_547	1120-0019	5.02	610.0 nM	1.87E-7	azole & statin	14	2.65E-7
7	SGTC_935	2996-0153	4.46	430.0 µM	3.02E-6	PDR1	12	4.03E-6
8	SGTC_73	0327-0325	4.15	16.2 µM	1.27E-5	DNA damage response	42	1.65E-5
9	SGTC_6	0844-0013	4.03	19.8 µM	2.16E-5		80	2.78E-5
10	SGTC_2117	5521686	3.88	200.0 µM	4.08E-5		14	5.16E-5
11	SGTC_1993	st073995	3.81	70.8 µM	5.43E-5		23	6.83E-5
12	SGTC_1984	st072354	3.80	53.1 µM	5.71E-5		17	7.16E-5
13	SGTC_1143	3454-2408	3.70	5.1 µM	8.62E-5	60S ribosome export	3	1.07E-4
14	SGTC_252	miconazole	3.58	1.3 nM	1.39E-4	ergosterol depletion effects on membrane	42	1.71E-4
15	SGTC_121	0557-0495	3.57	61.3 µM	1.43E-4	calcium & mitochondrial duress	78	1.77E-4
16	SGTC_2770	toltrazuril	3.53	17.5 µM	1.69E-4		39	2.07E-4
17	SGTC_1958	st076513	3.47	41.9 µM	2.15E-4	60S ribosome export	49	2.62E-4
18	SGTC_249	wiskostatin	3.46	11.2 µM	2.21E-4		28	2.70E-4
19	SGTC_815	1582-0027	3.39	36.9 µM	2.91E-4		56	3.53E-4
20	SGTC_2239	6685329	3.37	187.6 µM	3.06E-4		53	3.70E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.340	3.01E-91	YDR475C	JIP4	hom	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.273	3.41E-58	YDL019C	OSH2	hom	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.259	2.47E-52	YDR467C_d	YDR467C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.245	3.59E-47	YOR086C	TCB1	hom	Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.232	2.86E-42	YKL051W	SFK1	hom	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.226	5.48E-40	YBL051C	PIN4	hom	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.212	2.83E-35	YDR466W	PKH3	hom	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.208	4.90E-34	YJL164C	TPK1	hom	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.199	4.86E-31	YJL165C	HAL5	hom	Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.198	7.33E-31	YDL021W	GPM2	hom	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.193	1.41E-29	YKL061W_p	BLI1_p	hom	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.180	6.92E-26	YNL288W	CAF40	hom	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.171	2.32E-23	YPL145C	KES1	hom	One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.169	6.27E-23	YBL022C	PIM1	hom	ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.162	4.81E-21	YHL002W	HSE1	hom	Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes