YGR242W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR242W / YGR242W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.21|P-value:1.39E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:3.13|P-value:9.32E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.59|P-value:2.48E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:3.57|P-value:1.93E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.15|P-value:8.79E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.35|P-value:4.32E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.57|P-value:2.79E-6 ID:SGTC_509|Compound:pifithrin|FD-Score:3.94|P-value:4.42E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-5.08|P-value:2.07E-7 ID:SGTC_571|Compound:k831-0106|FD-Score:3.19|P-value:7.47E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.46|P-value:2.92E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.22|P-value:6.89E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.59|P-value:1.76E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.32|P-value:4.89E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.42|P-value:3.29E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:4.27|P-value:1.06E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.29|P-value:5.27E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.58|P-value:1.82E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.44|P-value:3.07E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.19|P-value:7.50E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.21|P-value:7.12E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.79|P-value:8.10E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.28|P-value:5.51E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.36|P-value:4.12E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.63|P-value:1.55E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.23|P-value:6.54E-4 ID:SGTC_1661|Compound:st013063|FD-Score:4.16|P-value:1.75E-5 ID:SGTC_1733|Compound:st037357|FD-Score:10.60|P-value:3.24E-26 ID:SGTC_1910|Compound:st062352|FD-Score:6.76|P-value:9.00E-12 ID:SGTC_2081|Compound:5214970|FD-Score:4.23|P-value:1.27E-5 ID:SGTC_2116|Compound:5511452|FD-Score:4.10|P-value:2.27E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.84|P-value:6.63E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.74|P-value:9.86E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.75|P-value:9.49E-5 ID:SGTC_2404|Compound:5161160|FD-Score:3.25|P-value:6.12E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.26|P-value:1.11E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.44|P-value:3.11E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.41|P-value:3.52E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.13|P-value:9.23E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.06|P-value:2.74E-5 ID:SGTC_2781|Compound:5567276|FD-Score:4.32|P-value:8.68E-6 ID:SGTC_2782|Compound:7736369|FD-Score:5.21|P-value:1.12E-7 ID:SGTC_2824|Compound:7998404|FD-Score:4.19|P-value:1.52E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.71|P-value:1.14E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.15|P-value:8.81E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.47|P-value:2.77E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.01|P-value:3.32E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:4.21|P-value:1.39E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:3.13|P-value:9.32E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.59|P-value:2.48E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:3.57|P-value:1.93E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.15|P-value:8.79E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.35|P-value:4.32E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.57|P-value:2.79E-6 ID:SGTC_509|Compound:pifithrin|FD-Score:3.94|P-value:4.42E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-5.08|P-value:2.07E-7 ID:SGTC_571|Compound:k831-0106|FD-Score:3.19|P-value:7.47E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.46|P-value:2.92E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.22|P-value:6.89E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.59|P-value:1.76E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.32|P-value:4.89E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.42|P-value:3.29E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:4.27|P-value:1.06E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.29|P-value:5.27E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.58|P-value:1.82E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.44|P-value:3.07E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.19|P-value:7.50E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.21|P-value:7.12E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.79|P-value:8.10E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.28|P-value:5.51E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.36|P-value:4.12E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.63|P-value:1.55E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.23|P-value:6.54E-4 ID:SGTC_1661|Compound:st013063|FD-Score:4.16|P-value:1.75E-5 ID:SGTC_1733|Compound:st037357|FD-Score:10.60|P-value:3.24E-26 ID:SGTC_1910|Compound:st062352|FD-Score:6.76|P-value:9.00E-12 ID:SGTC_2081|Compound:5214970|FD-Score:4.23|P-value:1.27E-5 ID:SGTC_2116|Compound:5511452|FD-Score:4.10|P-value:2.27E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.84|P-value:6.63E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.74|P-value:9.86E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.75|P-value:9.49E-5 ID:SGTC_2404|Compound:5161160|FD-Score:3.25|P-value:6.12E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.26|P-value:1.11E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.44|P-value:3.11E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.41|P-value:3.52E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.13|P-value:9.23E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.06|P-value:2.74E-5 ID:SGTC_2781|Compound:5567276|FD-Score:4.32|P-value:8.68E-6 ID:SGTC_2782|Compound:7736369|FD-Score:5.21|P-value:1.12E-7 ID:SGTC_2824|Compound:7998404|FD-Score:4.19|P-value:1.52E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.71|P-value:1.14E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.15|P-value:8.81E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.47|P-value:2.77E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.01|P-value:3.32E-5

Top fitness defect scores for YGR242W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1733 st037357 10.60 54.9 µM 3.24E-26 60S ribosome export 1 1.87E-26
2 SGTC_1910 st062352 6.76 60.4 µM 9.00E-12 5 7.11E-12
3 SGTC_2782 7736369 5.21 71.4 µM 1.12E-7 15 9.66E-8
4 SGTC_103 0844-0104 4.59 51.8 µM 2.48E-6 ERAD & cell cycle 115 2.21E-6
5 SGTC_453 enantio-paf c16 4.57 10.0 µM 2.79E-6 106 2.49E-6
6 SGTC_2781 5567276 4.32 71.4 µM 8.68E-6 38 7.83E-6
7 SGTC_730 1436-0052 4.27 41.2 µM 1.06E-5 mitochondrial processes 8 9.58E-6
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.26 3.7 µM 1.11E-5 63 1.00E-5
9 SGTC_2081 5214970 4.23 32.3 µM 1.27E-5 20 1.15E-5
10 SGTC_6 0844-0013 4.21 19.8 µM 1.39E-5 69 1.26E-5
11 SGTC_2824 7998404 4.19 52.0 µM 1.52E-5 32 1.38E-5
12 SGTC_1661 st013063 4.16 9.7 µM 1.75E-5 23 1.59E-5
13 SGTC_2116 5511452 4.10 16.9 µM 2.27E-5 11 2.06E-5
14 SGTC_2777 climbazole 4.06 1.5 µM 2.74E-5 iron homeostasis 44 2.50E-5
15 SGTC_3274 9138298 4.01 49.5 µM 3.32E-5 21 3.03E-5
16 SGTC_509 pifithrin 3.94 175.0 µM 4.42E-5 mitochondrial processes 6 4.05E-5
17 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 3.84 122.8 µM 6.63E-5 11 6.10E-5
18 SGTC_1092 toremifene 3.79 6.3 µM 8.10E-5 21 7.46E-5
19 SGTC_2365 9042475 3.75 200.0 µM 9.49E-5 42 8.76E-5
20 SGTC_2283 7944793 3.74 200.0 µM 9.86E-5 57 9.10E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 4.46E-17 YHR039C MSC7 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
0.134 6.23E-15 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.131 2.16E-14 YKL014C URB1 het Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
0.126 2.16E-13 YNL120C_d YNL120C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
0.121 1.77E-12 YKL149C DBR1 hom RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
0.117 1.27E-11 YGR226C_d YGR226C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
0.115 2.70E-11 YGR027C RPS25A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication
0.113 5.23E-11 YLR361C DCR2 hom Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
0.111 1.08E-10 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.110 1.59E-10 YER128W VFA1 hom Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology
0.110 1.63E-10 YNL180C RHO5 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
0.109 2.17E-10 YLR278C_p YLR278C_p hom Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
0.109 2.23E-10 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.107 5.42E-10 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.104 1.67E-9 YER178W PDA1 hom E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose