HIPHOP chemogenomics database

YGR242W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR242W / YGR242W

Click on Significant Values for Screen Details

Top fitness defect scores for YGR242W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1733	st037357	10.60	54.9 µM	3.24E-26	60S ribosome export	1	1.87E-26
2	SGTC_1910	st062352	6.76	60.4 µM	9.00E-12		5	7.11E-12
3	SGTC_2782	7736369	5.21	71.4 µM	1.12E-7		15	9.66E-8
4	SGTC_103	0844-0104	4.59	51.8 µM	2.48E-6	ERAD & cell cycle	115	2.21E-6
5	SGTC_453	enantio-paf c16	4.57	10.0 µM	2.79E-6		106	2.49E-6
6	SGTC_2781	5567276	4.32	71.4 µM	8.68E-6		38	7.83E-6
7	SGTC_730	1436-0052	4.27	41.2 µM	1.06E-5	mitochondrial processes	8	9.58E-6
8	SGTC_2494	18-aminoabieta-8,11,13-triene sulfate	4.26	3.7 µM	1.11E-5		63	1.00E-5
9	SGTC_2081	5214970	4.23	32.3 µM	1.27E-5		20	1.15E-5
10	SGTC_6	0844-0013	4.21	19.8 µM	1.39E-5		69	1.26E-5
11	SGTC_2824	7998404	4.19	52.0 µM	1.52E-5		32	1.38E-5
12	SGTC_1661	st013063	4.16	9.7 µM	1.75E-5		23	1.59E-5
13	SGTC_2116	5511452	4.10	16.9 µM	2.27E-5		11	2.06E-5
14	SGTC_2777	climbazole	4.06	1.5 µM	2.74E-5	iron homeostasis	44	2.50E-5
15	SGTC_3274	9138298	4.01	49.5 µM	3.32E-5		21	3.03E-5
16	SGTC_509	pifithrin	3.94	175.0 µM	4.42E-5	mitochondrial processes	6	4.05E-5
17	SGTC_2209	5-(5-methyl-2-thenylidene)-Barbituric acid	3.84	122.8 µM	6.63E-5		11	6.10E-5
18	SGTC_1092	toremifene	3.79	6.3 µM	8.10E-5		21	7.46E-5
19	SGTC_2365	9042475	3.75	200.0 µM	9.49E-5		42	8.76E-5
20	SGTC_2283	7944793	3.74	200.0 µM	9.86E-5		57	9.10E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.144	4.46E-17	YHR039C	MSC7	hom	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
0.134	6.23E-15	YLR421C	RPN13	hom	Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.131	2.16E-14	YKL014C	URB1	het	Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
0.126	2.16E-13	YNL120C_d	YNL120C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
0.121	1.77E-12	YKL149C	DBR1	hom	RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
0.117	1.27E-11	YGR226C_d	YGR226C_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
0.115	2.70E-11	YGR027C	RPS25A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication
0.113	5.23E-11	YLR361C	DCR2	hom	Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
0.111	1.08E-10	YOR246C	ENV9	hom	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.110	1.59E-10	YER128W	VFA1	hom	Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology
0.110	1.63E-10	YNL180C	RHO5	hom	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
0.109	2.17E-10	YLR278C_p	YLR278C_p	hom	Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
0.109	2.23E-10	YOR155C	ISN1	hom	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.107	5.42E-10	YAR008W	SEN34	het	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.104	1.67E-9	YER178W	PDA1	hom	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose