YGR248W / SOL4

6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR248W / SOL4

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:-3.10|P-value:7.60E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.49|P-value:1.74E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.17|P-value:5.24E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.33|P-value:2.87E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.00|P-value:9.44E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.72|P-value:5.85E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.40|P-value:2.15E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.48|P-value:1.61E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.27|P-value:4.13E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.06|P-value:7.72E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.33|P-value:2.83E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.24|P-value:4.57E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:6.83|P-value:9.17E-13 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.11|P-value:1.09E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.97|P-value:2.01E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.24|P-value:4.48E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.18|P-value:7.79E-6 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.69|P-value:6.77E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.36|P-value:3.29E-6 ID:SGTC_1766|Compound:st045414|FD-Score:-3.55|P-value:1.36E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.46|P-value:1.96E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.03|P-value:9.66E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.61|P-value:9.46E-5 ID:SGTC_1973|Compound:st070275|FD-Score:3.15|P-value:5.61E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.79|P-value:4.34E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-3.94|P-value:2.72E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.17|P-value:5.78E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.07|P-value:7.42E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.20|P-value:4.54E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.32|P-value:2.90E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-4.86|P-value:3.04E-7 ID:SGTC_2327|Compound:6189656|FD-Score:-3.21|P-value:5.00E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.05|P-value:9.02E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.27|P-value:5.08E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.88|P-value:2.32E-7 ID:SGTC_2780|Compound:5215298|FD-Score:4.67|P-value:6.91E-7 ID:SGTC_2787|Compound:5284540|FD-Score:3.75|P-value:5.30E-5 ID:SGTC_2892|Compound:9047358|FD-Score:3.02|P-value:8.93E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.15|P-value:5.60E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.62|P-value:9.05E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.53|P-value:1.47E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.04|P-value:8.13E-4 ID:SGTC_3213|Compound:9129884|FD-Score:4.73|P-value:5.20E-7 ID:SGTC_3215|Compound:9129942|FD-Score:5.06|P-value:8.75E-8 ID:SGTC_3217|Compound:9129673|FD-Score:-4.16|P-value:9.92E-6 ID:SGTC_3286|Compound:9117135|FD-Score:3.57|P-value:1.12E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.10|P-value:7.60E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.49|P-value:1.74E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.17|P-value:5.24E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.33|P-value:2.87E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.00|P-value:9.44E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.72|P-value:5.85E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.40|P-value:2.15E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.48|P-value:1.61E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.27|P-value:4.13E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.06|P-value:7.72E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.33|P-value:2.83E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.24|P-value:4.57E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:6.83|P-value:9.17E-13 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.11|P-value:1.09E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.97|P-value:2.01E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.24|P-value:4.48E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.18|P-value:7.79E-6 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.69|P-value:6.77E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.36|P-value:3.29E-6 ID:SGTC_1766|Compound:st045414|FD-Score:-3.55|P-value:1.36E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.46|P-value:1.96E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.03|P-value:9.66E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.61|P-value:9.46E-5 ID:SGTC_1973|Compound:st070275|FD-Score:3.15|P-value:5.61E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.79|P-value:4.34E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-3.94|P-value:2.72E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.17|P-value:5.78E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.07|P-value:7.42E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.20|P-value:4.54E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.32|P-value:2.90E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-4.86|P-value:3.04E-7 ID:SGTC_2327|Compound:6189656|FD-Score:-3.21|P-value:5.00E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.05|P-value:9.02E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.27|P-value:5.08E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.88|P-value:2.32E-7 ID:SGTC_2780|Compound:5215298|FD-Score:4.67|P-value:6.91E-7 ID:SGTC_2787|Compound:5284540|FD-Score:3.75|P-value:5.30E-5 ID:SGTC_2892|Compound:9047358|FD-Score:3.02|P-value:8.93E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.15|P-value:5.60E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.62|P-value:9.05E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.53|P-value:1.47E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.04|P-value:8.13E-4 ID:SGTC_3213|Compound:9129884|FD-Score:4.73|P-value:5.20E-7 ID:SGTC_3215|Compound:9129942|FD-Score:5.06|P-value:8.75E-8 ID:SGTC_3217|Compound:9129673|FD-Score:-4.16|P-value:9.92E-6 ID:SGTC_3286|Compound:9117135|FD-Score:3.57|P-value:1.12E-4

Top fitness defect scores for YGR248W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1111 tnp00062 6.83 510.7 nM 9.17E-13 2 4.33E-12
2 SGTC_3215 9129942 5.06 49.5 µM 8.75E-8 1 2.13E-7
3 SGTC_2724 maprotiline 4.88 69.6 µM 2.32E-7 ERG2 5 5.35E-7
4 SGTC_3213 9129884 4.73 49.5 µM 5.20E-7 9 1.14E-6
5 SGTC_2780 5215298 4.67 71.4 µM 6.91E-7 22 1.49E-6
6 SGTC_1369 1866-0067 4.36 208.0 µM 3.29E-6 RPP1 & pyrimidine depletion 30 6.49E-6
7 SGTC_2438 5259590 4.27 200.0 µM 5.08E-6 15 9.78E-6
8 SGTC_1299 1079-1439 4.18 3.7 µM 7.79E-6 TSC3-RPN4 8 1.46E-5
9 SGTC_1114 scopoletin 4.11 1.7 µM 1.09E-5 18 2.00E-5
10 SGTC_1212 0520-0165 3.97 585.0 µM 2.01E-5 30 3.58E-5
11 SGTC_2123 5259487 3.79 200.0 µM 4.34E-5 22 7.38E-5
12 SGTC_2787 5284540 3.75 71.4 µM 5.30E-5 32 8.91E-5
13 SGTC_640 3381-0960 3.72 37.1 µM 5.85E-5 17 9.79E-5
14 SGTC_1360 1598-0022 3.69 39.8 µM 6.77E-5 ERG2 40 1.12E-4
15 SGTC_2927 9011802 3.62 47.9 µM 9.05E-5 36 1.48E-4
16 SGTC_1969 st069479 3.61 40.1 µM 9.46E-5 18 1.54E-4
17 SGTC_3286 9117135 3.57 37.2 µM 1.12E-4 24 1.81E-4
18 SGTC_882 0843-0131 3.48 351.0 µM 1.61E-4 24 2.55E-4
19 SGTC_823 0417-1665 3.40 178.0 µM 2.15E-4 54 3.34E-4
20 SGTC_991 3996-0057 3.33 64.7 µM 2.83E-4 38 4.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.34E-15 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.111 1.17E-10 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.110 1.76E-10 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
0.102 3.74E-9 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.099 9.32E-9 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.099 1.05E-8 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.098 1.32E-8 YLR146C SPE4 hom Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
0.097 1.53E-8 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.095 3.18E-8 YDL031W DBP10 het Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
0.093 6.06E-8 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.093 6.70E-8 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.087 5.12E-7 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.085 7.28E-7 YPR048W TAH18 het Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance
0.084 9.81E-7 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.084 1.27E-6 YLR215C CDC123 het Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein