YGR256W / GND2

6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR256W / GND2

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-3.36|P-value:1.75E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-5.65|P-value:9.55E-10 ID:SGTC_63|Compound:0099-0242|FD-Score:-3.20|P-value:3.34E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:4.55|P-value:6.26E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:3.07|P-value:5.33E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.28|P-value:2.44E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-2.96|P-value:8.17E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.63|P-value:5.53E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:2.91|P-value:9.62E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.76|P-value:3.18E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:4.46|P-value:1.04E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:3.44|P-value:1.26E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.06|P-value:5.71E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.19|P-value:3.45E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.72|P-value:3.85E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.20|P-value:3.26E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.44|P-value:1.26E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.25|P-value:2.70E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.35|P-value:1.79E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.89|P-value:1.75E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.38|P-value:1.57E-6 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.32|P-value:2.01E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.88|P-value:1.85E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.43|P-value:1.30E-4 ID:SGTC_1554|Compound:st069299|FD-Score:4.53|P-value:6.94E-7 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.38|P-value:1.63E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.06|P-value:5.56E-4 ID:SGTC_1636|Compound:st007707|FD-Score:6.33|P-value:8.03E-12 ID:SGTC_1637|Compound:st007924|FD-Score:3.02|P-value:6.52E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.02|P-value:6.56E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.40|P-value:1.39E-6 ID:SGTC_1757|Compound:st041620|FD-Score:5.08|P-value:3.16E-8 ID:SGTC_1774|Compound:st048371|FD-Score:-3.05|P-value:5.82E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.08|P-value:5.14E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-4.10|P-value:6.43E-6 ID:SGTC_2123|Compound:5259487|FD-Score:4.85|P-value:1.20E-7 ID:SGTC_2139|Compound:5578692|FD-Score:3.43|P-value:1.32E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.15|P-value:3.95E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-3.19|P-value:3.54E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.04|P-value:5.95E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.13|P-value:4.34E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.24|P-value:2.83E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.00|P-value:6.97E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.30|P-value:2.25E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.43|P-value:1.29E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.11|P-value:4.64E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.59|P-value:6.67E-5 ID:SGTC_2713|Compound:st079149|FD-Score:-3.95|P-value:1.32E-5 ID:SGTC_2717|Compound:st081029|FD-Score:3.43|P-value:1.28E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-4.21|P-value:3.81E-6 ID:SGTC_2952|Compound:9073731|FD-Score:-4.02|P-value:9.37E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-3.03|P-value:6.39E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-2.96|P-value:8.40E-4 ID:SGTC_3164|Compound:9100705|FD-Score:2.94|P-value:8.83E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.71|P-value:3.87E-5 ID:SGTC_3238|Compound:9133470|FD-Score:4.48|P-value:9.46E-7 ID:SGTC_3291|Compound:9121177|FD-Score:3.17|P-value:3.70E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.36|P-value:1.75E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-5.65|P-value:9.55E-10 ID:SGTC_63|Compound:0099-0242|FD-Score:-3.20|P-value:3.34E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:4.55|P-value:6.26E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:3.07|P-value:5.33E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.28|P-value:2.44E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-2.96|P-value:8.17E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.63|P-value:5.53E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:2.91|P-value:9.62E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.76|P-value:3.18E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:4.46|P-value:1.04E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:3.44|P-value:1.26E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.06|P-value:5.71E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.19|P-value:3.45E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.72|P-value:3.85E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.20|P-value:3.26E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.44|P-value:1.26E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.25|P-value:2.70E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.35|P-value:1.79E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.89|P-value:1.75E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.38|P-value:1.57E-6 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.32|P-value:2.01E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.88|P-value:1.85E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.43|P-value:1.30E-4 ID:SGTC_1554|Compound:st069299|FD-Score:4.53|P-value:6.94E-7 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.38|P-value:1.63E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.06|P-value:5.56E-4 ID:SGTC_1636|Compound:st007707|FD-Score:6.33|P-value:8.03E-12 ID:SGTC_1637|Compound:st007924|FD-Score:3.02|P-value:6.52E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.02|P-value:6.56E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.40|P-value:1.39E-6 ID:SGTC_1757|Compound:st041620|FD-Score:5.08|P-value:3.16E-8 ID:SGTC_1774|Compound:st048371|FD-Score:-3.05|P-value:5.82E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.08|P-value:5.14E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-4.10|P-value:6.43E-6 ID:SGTC_2123|Compound:5259487|FD-Score:4.85|P-value:1.20E-7 ID:SGTC_2139|Compound:5578692|FD-Score:3.43|P-value:1.32E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.15|P-value:3.95E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-3.19|P-value:3.54E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.04|P-value:5.95E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.13|P-value:4.34E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.24|P-value:2.83E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.00|P-value:6.97E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.30|P-value:2.25E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.43|P-value:1.29E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.11|P-value:4.64E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.59|P-value:6.67E-5 ID:SGTC_2713|Compound:st079149|FD-Score:-3.95|P-value:1.32E-5 ID:SGTC_2717|Compound:st081029|FD-Score:3.43|P-value:1.28E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-4.21|P-value:3.81E-6 ID:SGTC_2952|Compound:9073731|FD-Score:-4.02|P-value:9.37E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-3.03|P-value:6.39E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-2.96|P-value:8.40E-4 ID:SGTC_3164|Compound:9100705|FD-Score:2.94|P-value:8.83E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.71|P-value:3.87E-5 ID:SGTC_3238|Compound:9133470|FD-Score:4.48|P-value:9.46E-7 ID:SGTC_3291|Compound:9121177|FD-Score:3.17|P-value:3.70E-4

Top fitness defect scores for YGR256W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1636 st007707 6.33 68.9 µM 8.03E-12 20 1.22E-10
2 SGTC_1757 st041620 5.08 31.8 µM 3.16E-8 19 1.87E-7
3 SGTC_2123 5259487 4.85 200.0 µM 1.20E-7 8 6.12E-7
4 SGTC_74 000s-0487 4.55 160.3 µM 6.26E-7 16 2.64E-6
5 SGTC_1554 st069299 4.53 38.7 µM 6.94E-7 9 2.89E-6
6 SGTC_3238 9133470 4.48 49.5 µM 9.46E-7 5 3.81E-6
7 SGTC_727 3032-0951 4.46 202.0 µM 1.04E-6 21 4.14E-6
8 SGTC_1735 st034310 4.40 56.8 µM 1.39E-6 Golgi 16 5.34E-6
9 SGTC_1430 4049-0248 4.38 69.1 µM 1.57E-6 11 5.97E-6
10 SGTC_1414 3917-0015 3.89 5.4 µM 1.75E-5 11 5.08E-5
11 SGTC_1497 4476-2978 3.88 41.3 µM 1.85E-5 10 5.32E-5
12 SGTC_718 1130-0073 3.76 349.0 µM 3.18E-5 27 8.62E-5
13 SGTC_3195 9113082 3.71 49.5 µM 3.87E-5 25 1.03E-4
14 SGTC_599 1935-0052 3.63 86.5 µM 5.53E-5 23 1.41E-4
15 SGTC_2710 st078562 3.59 53.7 µM 6.67E-5 29 1.67E-4
16 SGTC_1119 parthenolide 3.44 318.5 nM 1.26E-4 TSC3-RPN4 64 2.93E-4
17 SGTC_756 0508-1999 3.44 28.3 µM 1.26E-4 RPP1 & pyrimidine depletion 49 2.93E-4
18 SGTC_2717 st081029 3.43 62.3 µM 1.28E-4 28 2.98E-4
19 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.43 66.7 µM 1.29E-4 45 3.00E-4
20 SGTC_1521 st012942 3.43 49.4 µM 1.30E-4 50 3.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.46E-11 YOR032C HMS1 hom Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
0.102 3.84E-9 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.101 4.41E-9 YOR161C PNS1 hom Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
0.100 6.72E-9 YGR247W CPD1 hom Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress
0.089 2.17E-7 YOR195W SLK19 hom Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
0.086 5.54E-7 YGR250C YGR250C hom Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.082 1.85E-6 YPL261C_d YPL261C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
0.078 5.83E-6 YHR135C YCK1 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication
0.077 9.00E-6 YLR289W GUF1 hom Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
0.074 1.85E-5 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.069 6.01E-5 YOR156C NFI1 hom SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length
0.069 6.36E-5 YDR338C_p YDR338C_p hom Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
0.068 8.44E-5 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.067 9.49E-5 YMR002W MIC17 hom Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.067 1.14E-4 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)