HIPHOP chemogenomics database
YGR264C / MES1 
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YGR264C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.124 | 4.81E-13 | YLR026C | SED5 | het | cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins |
| 0.119 | 4.99E-12 | YAL034C-B_d | YAL034C-B_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.104 | 1.57E-9 | YPR025C | CCL1 | het | Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters |
| 0.099 | 7.69E-9 | YDL008W | APC11 | het | Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity |
| 0.091 | 1.22E-7 | YDR471W | RPL27B | hom | Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication |
| 0.091 | 1.35E-7 | YNL203C_d | YNL203C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.089 | 2.15E-7 | YNL097C-B_p | YNL097C-B_p | hom | Putative protein of unknown function |
| 0.088 | 2.96E-7 | YDL012C | YDL012C | hom | Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication |
| 0.087 | 4.18E-7 | YPL218W | SAR1 | het | GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport |
| 0.084 | 1.19E-6 | YKL179C | COY1 | hom | Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function |
| 0.083 | 1.54E-6 | YBR274W | CHK1 | hom | Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase |
| 0.082 | 2.12E-6 | YLR100W | ERG27 | het | 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs |
| 0.079 | 5.13E-6 | YGL108C | YGL108C | hom | Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress |
| 0.077 | 7.02E-6 | YNR071C_p | YNR071C_p | hom | Putative aldose 1-epimerase |
| 0.075 | 1.35E-5 | YKL220C | FRE2 | hom | Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels |