HIPHOP chemogenomics database
YGR277C / CAB4 
Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YGR277C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.140 | 4.18E-16 | YIL002W-A_p | YIL002W-A_p | hom | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
| 0.113 | 5.37E-11 | YER086W | ILV1 | hom | Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation |
| 0.111 | 9.91E-11 | YGL032C | AGA2 | hom | Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds |
| 0.100 | 7.12E-9 | YER046W | SPO73 | hom | Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis |
| 0.099 | 9.29E-9 | YLR336C | SGD1 | het | Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia |
| 0.099 | 1.04E-8 | YNL257C | SIP3 | hom | Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication |
| 0.096 | 2.56E-8 | YIR021W-A_p | YIR021W-A_p | hom | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
| 0.094 | 4.21E-8 | YDL109C_p | YDL109C_p | hom | Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication |
| 0.093 | 7.69E-8 | YNL011C_p | YNL011C_p | hom | Putative protein of unknown function; YNL011C is not an essential gene |
| 0.091 | 1.34E-7 | YBR072C-A_p | YBR072C-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
| 0.089 | 2.43E-7 | YHR025W | THR1 | hom | Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway |
| 0.087 | 4.10E-7 | YCR073C | SSK22 | hom | MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p |
| 0.087 | 5.02E-7 | YHL041W_d | YHL041W_d | hom | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data |
| 0.084 | 1.26E-6 | YJL035C | TAD2 | het | Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs |
| 0.083 | 1.54E-6 | YGL194C | HOS2 | hom | Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS |