YGR285C / ZUO1

Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR285C / ZUO1

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:3.89|P-value:7.27E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:7.43|P-value:2.28E-13 ID:SGTC_40|Compound:0327-0103|FD-Score:3.79|P-value:1.06E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:5.85|P-value:5.92E-9 ID:SGTC_117|Compound:lucigenin|FD-Score:5.16|P-value:2.39E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.55|P-value:2.57E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.38|P-value:5.76E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.30|P-value:7.48E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.84|P-value:1.31E-11 ID:SGTC_187|Compound:1488-2104|FD-Score:8.96|P-value:1.44E-18 ID:SGTC_197|Compound:4544-0043|FD-Score:16.20|P-value:2.30E-56 ID:SGTC_201|Compound:4262-0159|FD-Score:4.76|P-value:1.68E-6 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.87|P-value:7.88E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.44|P-value:3.86E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.45|P-value:4.43E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:10.20|P-value:1.39E-23 ID:SGTC_258|Compound:haloperidol|FD-Score:3.83|P-value:8.91E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:5.56|P-value:2.96E-8 ID:SGTC_263|Compound:alizarin|FD-Score:-3.34|P-value:6.55E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.51|P-value:3.68E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.28|P-value:6.67E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.33|P-value:9.86E-8 ID:SGTC_351|Compound:caspofungin|FD-Score:8.91|P-value:2.17E-18 ID:SGTC_369|Compound:0957-0393|FD-Score:4.83|P-value:1.23E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:5.25|P-value:1.50E-7 ID:SGTC_447|Compound:ml7|FD-Score:3.32|P-value:5.79E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.08|P-value:4.68E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:8.90|P-value:2.28E-18 ID:SGTC_500|Compound:h-89|FD-Score:6.35|P-value:3.11E-10 ID:SGTC_502|Compound:l-744,832|FD-Score:11.00|P-value:8.48E-27 ID:SGTC_528|Compound:3492-0019|FD-Score:7.42|P-value:2.56E-13 ID:SGTC_579|Compound:4491-1009|FD-Score:3.52|P-value:2.83E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:13.70|P-value:6.93E-41 ID:SGTC_625|Compound:k213-0058|FD-Score:3.56|P-value:2.47E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.54|P-value:2.68E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.66|P-value:1.71E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.32|P-value:1.23E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:4.86|P-value:1.04E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:6.17|P-value:8.84E-10 ID:SGTC_832|Compound:4083-0019|FD-Score:3.60|P-value:2.12E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:5.78|P-value:8.73E-9 ID:SGTC_997|Compound:3996-0078|FD-Score:3.94|P-value:5.81E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:5.19|P-value:2.09E-7 ID:SGTC_1199|Compound:1638-0010|FD-Score:5.04|P-value:4.49E-7 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.60|P-value:3.49E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.50|P-value:4.15E-8 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.56|P-value:2.45E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.92|P-value:6.35E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.24|P-value:1.63E-7 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.22|P-value:8.03E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.41|P-value:4.33E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:5.98|P-value:2.70E-9 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.62|P-value:2.02E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.14|P-value:1.79E-12 ID:SGTC_1620|Compound:st003704|FD-Score:5.49|P-value:4.29E-8 ID:SGTC_1621|Compound:st003705|FD-Score:3.78|P-value:1.09E-4 ID:SGTC_1622|Compound:st003707|FD-Score:10.30|P-value:9.47E-24 ID:SGTC_1623|Compound:st003709|FD-Score:8.43|P-value:1.12E-16 ID:SGTC_1624|Compound:st003710|FD-Score:8.02|P-value:2.98E-15 ID:SGTC_1626|Compound:st003712|FD-Score:3.92|P-value:6.51E-5 ID:SGTC_1627|Compound:st003713|FD-Score:7.64|P-value:5.00E-14 ID:SGTC_1650|Compound:st011916|FD-Score:-3.26|P-value:8.47E-4 ID:SGTC_1666|Compound:st014829|FD-Score:5.63|P-value:2.03E-8 ID:SGTC_1712|Compound:st032288|FD-Score:6.28|P-value:4.61E-10 ID:SGTC_1750|Compound:st081859|FD-Score:5.30|P-value:1.15E-7 ID:SGTC_1757|Compound:st041620|FD-Score:3.66|P-value:1.75E-4 ID:SGTC_1812|Compound:st052057|FD-Score:7.69|P-value:3.37E-14 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.27|P-value:6.96E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.81|P-value:9.70E-5 ID:SGTC_1983|Compound:st071813|FD-Score:3.30|P-value:6.12E-4 ID:SGTC_2046|Compound:4110841|FD-Score:6.09|P-value:1.50E-9 ID:SGTC_2111|Compound:5486399|FD-Score:4.20|P-value:2.00E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.08|P-value:3.32E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.60|P-value:2.12E-4 ID:SGTC_2304|Compound:7443016|FD-Score:4.44|P-value:7.31E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-3.37|P-value:5.97E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-4.06|P-value:4.60E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.38|P-value:4.70E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.23|P-value:9.54E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.37|P-value:4.89E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.22|P-value:8.22E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.34|P-value:5.47E-4 ID:SGTC_2523|Compound:spermine|FD-Score:7.36|P-value:3.90E-13 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.33|P-value:5.59E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.34|P-value:1.15E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.83|P-value:9.11E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.80|P-value:1.73E-11 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.86|P-value:8.03E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.63|P-value:1.95E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.42|P-value:7.85E-6 ID:SGTC_3002|Compound:9075603|FD-Score:4.13|P-value:2.75E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.59|P-value:2.27E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.62|P-value:2.02E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.89|P-value:7.27E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:7.43|P-value:2.28E-13 ID:SGTC_40|Compound:0327-0103|FD-Score:3.79|P-value:1.06E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:5.85|P-value:5.92E-9 ID:SGTC_117|Compound:lucigenin|FD-Score:5.16|P-value:2.39E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.55|P-value:2.57E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.38|P-value:5.76E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.30|P-value:7.48E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.84|P-value:1.31E-11 ID:SGTC_187|Compound:1488-2104|FD-Score:8.96|P-value:1.44E-18 ID:SGTC_197|Compound:4544-0043|FD-Score:16.20|P-value:2.30E-56 ID:SGTC_201|Compound:4262-0159|FD-Score:4.76|P-value:1.68E-6 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.87|P-value:7.88E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.44|P-value:3.86E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.45|P-value:4.43E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:10.20|P-value:1.39E-23 ID:SGTC_258|Compound:haloperidol|FD-Score:3.83|P-value:8.91E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:5.56|P-value:2.96E-8 ID:SGTC_263|Compound:alizarin|FD-Score:-3.34|P-value:6.55E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.51|P-value:3.68E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.28|P-value:6.67E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.33|P-value:9.86E-8 ID:SGTC_351|Compound:caspofungin|FD-Score:8.91|P-value:2.17E-18 ID:SGTC_369|Compound:0957-0393|FD-Score:4.83|P-value:1.23E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:5.25|P-value:1.50E-7 ID:SGTC_447|Compound:ml7|FD-Score:3.32|P-value:5.79E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.08|P-value:4.68E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:8.90|P-value:2.28E-18 ID:SGTC_500|Compound:h-89|FD-Score:6.35|P-value:3.11E-10 ID:SGTC_502|Compound:l-744,832|FD-Score:11.00|P-value:8.48E-27 ID:SGTC_528|Compound:3492-0019|FD-Score:7.42|P-value:2.56E-13 ID:SGTC_579|Compound:4491-1009|FD-Score:3.52|P-value:2.83E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:13.70|P-value:6.93E-41 ID:SGTC_625|Compound:k213-0058|FD-Score:3.56|P-value:2.47E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.54|P-value:2.68E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.66|P-value:1.71E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.32|P-value:1.23E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:4.86|P-value:1.04E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:6.17|P-value:8.84E-10 ID:SGTC_832|Compound:4083-0019|FD-Score:3.60|P-value:2.12E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:5.78|P-value:8.73E-9 ID:SGTC_997|Compound:3996-0078|FD-Score:3.94|P-value:5.81E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:5.19|P-value:2.09E-7 ID:SGTC_1199|Compound:1638-0010|FD-Score:5.04|P-value:4.49E-7 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.60|P-value:3.49E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.50|P-value:4.15E-8 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.56|P-value:2.45E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.92|P-value:6.35E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.24|P-value:1.63E-7 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.22|P-value:8.03E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.41|P-value:4.33E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:5.98|P-value:2.70E-9 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.62|P-value:2.02E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.14|P-value:1.79E-12 ID:SGTC_1620|Compound:st003704|FD-Score:5.49|P-value:4.29E-8 ID:SGTC_1621|Compound:st003705|FD-Score:3.78|P-value:1.09E-4 ID:SGTC_1622|Compound:st003707|FD-Score:10.30|P-value:9.47E-24 ID:SGTC_1623|Compound:st003709|FD-Score:8.43|P-value:1.12E-16 ID:SGTC_1624|Compound:st003710|FD-Score:8.02|P-value:2.98E-15 ID:SGTC_1626|Compound:st003712|FD-Score:3.92|P-value:6.51E-5 ID:SGTC_1627|Compound:st003713|FD-Score:7.64|P-value:5.00E-14 ID:SGTC_1650|Compound:st011916|FD-Score:-3.26|P-value:8.47E-4 ID:SGTC_1666|Compound:st014829|FD-Score:5.63|P-value:2.03E-8 ID:SGTC_1712|Compound:st032288|FD-Score:6.28|P-value:4.61E-10 ID:SGTC_1750|Compound:st081859|FD-Score:5.30|P-value:1.15E-7 ID:SGTC_1757|Compound:st041620|FD-Score:3.66|P-value:1.75E-4 ID:SGTC_1812|Compound:st052057|FD-Score:7.69|P-value:3.37E-14 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.27|P-value:6.96E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.81|P-value:9.70E-5 ID:SGTC_1983|Compound:st071813|FD-Score:3.30|P-value:6.12E-4 ID:SGTC_2046|Compound:4110841|FD-Score:6.09|P-value:1.50E-9 ID:SGTC_2111|Compound:5486399|FD-Score:4.20|P-value:2.00E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.08|P-value:3.32E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.60|P-value:2.12E-4 ID:SGTC_2304|Compound:7443016|FD-Score:4.44|P-value:7.31E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-3.37|P-value:5.97E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-4.06|P-value:4.60E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.38|P-value:4.70E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.23|P-value:9.54E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.37|P-value:4.89E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.22|P-value:8.22E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.34|P-value:5.47E-4 ID:SGTC_2523|Compound:spermine|FD-Score:7.36|P-value:3.90E-13 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.33|P-value:5.59E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.34|P-value:1.15E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.83|P-value:9.11E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.80|P-value:1.73E-11 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.86|P-value:8.03E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.63|P-value:1.95E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.42|P-value:7.85E-6 ID:SGTC_3002|Compound:9075603|FD-Score:4.13|P-value:2.75E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.59|P-value:2.27E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.62|P-value:2.02E-4

Top fitness defect scores for YGR285C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_197 4544-0043 16.20 41.6 µM 2.30E-56 endomembrane recycling 1 1.53E-59
2 SGTC_582 0987-0078 13.70 156.0 µM 6.93E-41 calcium & mitochondrial duress 3 3.90E-43
3 SGTC_502 l-744,832 11.00 89.3 µM 8.48E-27 calcium & mitochondrial duress 3 3.28E-28
4 SGTC_1622 st003707 10.30 19.4 µM 9.47E-24 calcium & mitochondrial duress 3 5.55E-25
5 SGTC_257 daunorubicin 10.20 18.5 µM 1.39E-23 anthracycline transcription coupled DNA repair 3 8.30E-25
6 SGTC_187 1488-2104 8.96 32.7 µM 1.44E-18 calcium & mitochondrial duress 5 1.69E-19
7 SGTC_351 caspofungin 8.91 25.0 nM 2.17E-18 cell wall 11 2.61E-19
8 SGTC_467 ro 31-8220 8.90 72.8 µM 2.28E-18 calcium & mitochondrial duress 12 2.76E-19
9 SGTC_1623 st003709 8.43 20.3 µM 1.12E-16 calcium & mitochondrial duress 4 1.70E-17
10 SGTC_1624 st003710 8.02 6.2 µM 2.98E-15 calcium & mitochondrial duress 5 5.47E-16
11 SGTC_1812 st052057 7.69 4.3 µM 3.37E-14 calcium & mitochondrial duress 4 7.10E-15
12 SGTC_1627 st003713 7.64 25.6 µM 5.00E-14 calcium & mitochondrial duress 16 1.08E-14
13 SGTC_39 0986-0283 7.43 58.4 µM 2.28E-13 calcium & mitochondrial duress 3 5.37E-14
14 SGTC_528 3492-0019 7.42 172.0 µM 2.56E-13 calcium & mitochondrial duress 90 6.05E-14
15 SGTC_2523 spermine 7.36 47.7 µM 3.90E-13 calcium & mitochondrial duress 8 9.46E-14
16 SGTC_1597 7-benzyloxygramine 7.14 47.5 µM 1.79E-12 calcium & mitochondrial duress 36 4.73E-13
17 SGTC_149 3970-0822 6.84 46.1 µM 1.31E-11 tubulin folding & SWR complex 22 3.88E-12
18 SGTC_2737 bleomycin 6.80 30.5 nM 1.73E-11 Golgi 23 5.22E-12
19 SGTC_500 h-89 6.35 112.0 µM 3.11E-10 cell wall signaling 8 1.10E-10
20 SGTC_1712 st032288 6.28 53.4 µM 4.61E-10 calcium & mitochondrial duress 72 1.67E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.443 2.49E-161 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.434 1.72E-154 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.422 9.41E-145 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.340 3.34E-91 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.303 4.32E-72 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.267 5.59E-56 YDL160C DHH1 hom Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
0.265 4.12E-55 YBR109C CMD1 het Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
0.257 7.39E-52 YKL212W SAC1 hom Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism
0.257 9.42E-52 YMR202W ERG2 hom C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
0.253 3.60E-50 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.250 4.26E-49 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.234 4.77E-43 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.202 4.07E-32 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.201 5.55E-32 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.201 1.49E-31 YNL323W LEM3 hom Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane