YGR289C / MAL11

Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR289C / MAL11

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:6.42|P-value:1.07E-9 ID:SGTC_16|Compound:erodoxin|FD-Score:3.75|P-value:2.34E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.48|P-value:1.48E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.57|P-value:4.47E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:5.10|P-value:9.95E-7 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.68|P-value:2.82E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.44|P-value:1.99E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:8.50|P-value:1.06E-15 ID:SGTC_165|Compound:k038-0023|FD-Score:4.83|P-value:3.31E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.74|P-value:2.26E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:6.44|P-value:9.30E-10 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.43|P-value:1.68E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.77|P-value:2.04E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.51|P-value:5.42E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.96|P-value:1.88E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:5.69|P-value:5.52E-8 ID:SGTC_798|Compound:1287-0182|FD-Score:3.51|P-value:5.33E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.86|P-value:1.63E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.32|P-value:9.83E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.22|P-value:4.21E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:3.92|P-value:1.31E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.67|P-value:6.72E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.93|P-value:2.12E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.08|P-value:6.58E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.18|P-value:4.48E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.46|P-value:6.27E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.75|P-value:2.16E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.87|P-value:1.55E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.33|P-value:9.70E-4 ID:SGTC_1643|Compound:st009866|FD-Score:3.39|P-value:7.84E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:10.80|P-value:2.81E-24 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.71|P-value:2.48E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.40|P-value:2.08E-5 ID:SGTC_1760|Compound:st045453|FD-Score:-3.68|P-value:2.80E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.35|P-value:9.19E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-3.34|P-value:8.58E-4 ID:SGTC_2144|Compound:5628481|FD-Score:-5.45|P-value:1.66E-7 ID:SGTC_2154|Compound:5570129|FD-Score:4.89|P-value:2.52E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-3.88|P-value:1.38E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.77|P-value:2.22E-4 ID:SGTC_2301|Compound:7769476|FD-Score:4.21|P-value:4.29E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.66|P-value:7.02E-6 ID:SGTC_2350|Compound:9023895|FD-Score:3.39|P-value:7.94E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.27|P-value:2.51E-9 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.02|P-value:9.10E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-4.51|P-value:1.17E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:4.00|P-value:9.83E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.49|P-value:1.29E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.96|P-value:1.12E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.51|P-value:1.33E-5 ID:SGTC_3037|Compound:9091026|FD-Score:5.26|P-value:4.76E-7 ID:SGTC_3152|Compound:9099253|FD-Score:5.23|P-value:5.49E-7 ID:SGTC_3190|Compound:9110366|FD-Score:3.45|P-value:6.62E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.44|P-value:6.78E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.93|P-value:1.24E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.15|P-value:4.94E-5 ID:SGTC_3355|Compound:9151058|FD-Score:3.76|P-value:2.32E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:6.42|P-value:1.07E-9 ID:SGTC_16|Compound:erodoxin|FD-Score:3.75|P-value:2.34E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.48|P-value:1.48E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.57|P-value:4.47E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:5.10|P-value:9.95E-7 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.68|P-value:2.82E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.44|P-value:1.99E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:8.50|P-value:1.06E-15 ID:SGTC_165|Compound:k038-0023|FD-Score:4.83|P-value:3.31E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.74|P-value:2.26E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:6.44|P-value:9.30E-10 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.43|P-value:1.68E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.77|P-value:2.04E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.51|P-value:5.42E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.96|P-value:1.88E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:5.69|P-value:5.52E-8 ID:SGTC_798|Compound:1287-0182|FD-Score:3.51|P-value:5.33E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.86|P-value:1.63E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.32|P-value:9.83E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.22|P-value:4.21E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:3.92|P-value:1.31E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.67|P-value:6.72E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.93|P-value:2.12E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.08|P-value:6.58E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.18|P-value:4.48E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.46|P-value:6.27E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.75|P-value:2.16E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.87|P-value:1.55E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.33|P-value:9.70E-4 ID:SGTC_1643|Compound:st009866|FD-Score:3.39|P-value:7.84E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:10.80|P-value:2.81E-24 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.71|P-value:2.48E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.40|P-value:2.08E-5 ID:SGTC_1760|Compound:st045453|FD-Score:-3.68|P-value:2.80E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.35|P-value:9.19E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-3.34|P-value:8.58E-4 ID:SGTC_2144|Compound:5628481|FD-Score:-5.45|P-value:1.66E-7 ID:SGTC_2154|Compound:5570129|FD-Score:4.89|P-value:2.52E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-3.88|P-value:1.38E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.77|P-value:2.22E-4 ID:SGTC_2301|Compound:7769476|FD-Score:4.21|P-value:4.29E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.66|P-value:7.02E-6 ID:SGTC_2350|Compound:9023895|FD-Score:3.39|P-value:7.94E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.27|P-value:2.51E-9 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.02|P-value:9.10E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-4.51|P-value:1.17E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:4.00|P-value:9.83E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.49|P-value:1.29E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.96|P-value:1.12E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.51|P-value:1.33E-5 ID:SGTC_3037|Compound:9091026|FD-Score:5.26|P-value:4.76E-7 ID:SGTC_3152|Compound:9099253|FD-Score:5.23|P-value:5.49E-7 ID:SGTC_3190|Compound:9110366|FD-Score:3.45|P-value:6.62E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.44|P-value:6.78E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.93|P-value:1.24E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.15|P-value:4.94E-5 ID:SGTC_3355|Compound:9151058|FD-Score:3.76|P-value:2.32E-4

Top fitness defect scores for YGR289C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1679 4130-1276 10.80 6.7 µM 2.81E-24 Golgi 8 1.44E-27
2 SGTC_158 k038-0087 8.50 26.4 µM 1.06E-15 ubiquinone biosynthesis & proteasome 44 9.43E-18
3 SGTC_312 4092-0653 6.44 6.8 µM 9.30E-10 ergosterol depletion effects on membrane 34 5.89E-11
4 SGTC_8 0354-0001 6.42 70.0 µM 1.07E-9 22 6.92E-11
5 SGTC_2408 sulbentine 6.27 18.4 µM 2.51E-9 21 1.84E-10
6 SGTC_794 k038-0031 5.69 316.0 µM 5.52E-8 ubiquinone biosynthesis & proteasome 64 6.28E-9
7 SGTC_157 1348-1695 5.44 65.8 µM 1.99E-7 iron homeostasis 26 2.72E-8
8 SGTC_3037 9091026 5.26 49.5 µM 4.76E-7 NEO1-PIK1 62 7.35E-8
9 SGTC_3152 9099253 5.23 49.5 µM 5.49E-7 NEO1-PIK1 76 8.66E-8
10 SGTC_71 0417-1750 5.10 47.8 µM 9.95E-7 Golgi 23 1.71E-7
11 SGTC_669 0108-0021 4.96 26.2 µM 1.88E-6 fatty acid desaturase (OLE1) 38 3.53E-7
12 SGTC_1226 3909-7979 4.93 35.4 µM 2.12E-6 23 4.05E-7
13 SGTC_2154 5570129 4.89 200.0 µM 2.52E-6 2 4.94E-7
14 SGTC_165 k038-0023 4.83 64.4 µM 3.31E-6 ubiquinone biosynthesis & proteasome 47 6.73E-7
15 SGTC_1072 oxiconazole 4.67 14.9 nM 6.72E-6 ergosterol depletion effects on membrane 37 1.51E-6
16 SGTC_2322 7413319 4.66 38.2 µM 7.02E-6 ERAD & cell cycle 116 1.59E-6
17 SGTC_2778 tioconazole 4.51 65.1 nM 1.33E-5 ergosterol depletion effects on membrane 48 3.28E-6
18 SGTC_36 0335-0881 4.48 14.2 µM 1.48E-5 ubiquinone biosynthesis & proteasome 97 3.72E-6
19 SGTC_1745 st081495 4.40 74.0 µM 2.08E-5 RNA processing & uracil transport 63 5.48E-6
20 SGTC_939 1165-0479 4.22 45.3 µM 4.21E-5 21 1.22E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 3.15E-31 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.191 9.02E-29 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.176 1.29E-24 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.175 1.36E-24 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.172 1.20E-23 YBR102C EXO84 het Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
0.172 1.27E-23 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.172 1.57E-23 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.168 1.12E-22 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.163 2.54E-21 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.161 5.47E-21 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.155 1.67E-19 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.155 2.18E-19 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.150 3.04E-18 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.149 3.49E-18 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.148 6.85E-18 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data