YGR292W / MAL12

Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR292W / MAL12

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.86|P-value:4.24E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.27|P-value:4.28E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.24|P-value:4.87E-7 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.86|P-value:4.83E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-4.10|P-value:1.11E-6 ID:SGTC_289|Compound:k017-0060|FD-Score:-2.68|P-value:9.83E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.95|P-value:2.60E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:2.91|P-value:3.96E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.92|P-value:6.82E-9 ID:SGTC_686|Compound:1319-0111|FD-Score:3.04|P-value:2.23E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.97|P-value:2.37E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:-2.86|P-value:4.77E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-5.13|P-value:1.66E-9 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.72|P-value:8.55E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-2.72|P-value:8.56E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-2.82|P-value:5.66E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.88|P-value:9.19E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.96|P-value:5.40E-9 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.74|P-value:7.85E-6 ID:SGTC_1808|Compound:st050063|FD-Score:2.72|P-value:8.56E-4 ID:SGTC_1810|Compound:st050138|FD-Score:2.76|P-value:7.10E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.02|P-value:2.41E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.75|P-value:7.50E-6 ID:SGTC_2238|Compound:6671620|FD-Score:-4.03|P-value:1.66E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.96|P-value:2.44E-6 ID:SGTC_2293|Compound:7624732|FD-Score:-2.75|P-value:7.43E-4 ID:SGTC_2306|Compound:7482397|FD-Score:2.69|P-value:9.36E-4 ID:SGTC_2338|Compound:7999974|FD-Score:5.15|P-value:1.41E-9 ID:SGTC_2458|Compound:5808907|FD-Score:2.83|P-value:5.46E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.05|P-value:2.12E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.09|P-value:1.82E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.52|P-value:2.47E-5 ID:SGTC_2843|Compound:9000894|FD-Score:3.81|P-value:5.51E-6 ID:SGTC_2933|Compound:9026794|FD-Score:-3.22|P-value:9.97E-5 ID:SGTC_2989|Compound:9073649|FD-Score:6.80|P-value:2.11E-15 ID:SGTC_2991|Compound:9074669|FD-Score:3.16|P-value:1.34E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-2.69|P-value:9.68E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.86|P-value:4.24E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.27|P-value:4.28E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.24|P-value:4.87E-7 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.86|P-value:4.83E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-4.10|P-value:1.11E-6 ID:SGTC_289|Compound:k017-0060|FD-Score:-2.68|P-value:9.83E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.95|P-value:2.60E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:2.91|P-value:3.96E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.92|P-value:6.82E-9 ID:SGTC_686|Compound:1319-0111|FD-Score:3.04|P-value:2.23E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.97|P-value:2.37E-6 ID:SGTC_889|Compound:0919-1524|FD-Score:-2.86|P-value:4.77E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-5.13|P-value:1.66E-9 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.72|P-value:8.55E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-2.72|P-value:8.56E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-2.82|P-value:5.66E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.88|P-value:9.19E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.96|P-value:5.40E-9 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.74|P-value:7.85E-6 ID:SGTC_1808|Compound:st050063|FD-Score:2.72|P-value:8.56E-4 ID:SGTC_1810|Compound:st050138|FD-Score:2.76|P-value:7.10E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.02|P-value:2.41E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.75|P-value:7.50E-6 ID:SGTC_2238|Compound:6671620|FD-Score:-4.03|P-value:1.66E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.96|P-value:2.44E-6 ID:SGTC_2293|Compound:7624732|FD-Score:-2.75|P-value:7.43E-4 ID:SGTC_2306|Compound:7482397|FD-Score:2.69|P-value:9.36E-4 ID:SGTC_2338|Compound:7999974|FD-Score:5.15|P-value:1.41E-9 ID:SGTC_2458|Compound:5808907|FD-Score:2.83|P-value:5.46E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.05|P-value:2.12E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.09|P-value:1.82E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.52|P-value:2.47E-5 ID:SGTC_2843|Compound:9000894|FD-Score:3.81|P-value:5.51E-6 ID:SGTC_2933|Compound:9026794|FD-Score:-3.22|P-value:9.97E-5 ID:SGTC_2989|Compound:9073649|FD-Score:6.80|P-value:2.11E-15 ID:SGTC_2991|Compound:9074669|FD-Score:3.16|P-value:1.34E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-2.69|P-value:9.68E-4

Top fitness defect scores for YGR292W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2989 9073649 6.80 71.4 µM 2.11E-15 6 5.16E-12
2 SGTC_2338 7999974 5.15 200.0 µM 1.41E-9 6 1.31E-7
3 SGTC_534 k292-0788 4.92 63.4 µM 6.82E-9 mitochondrial processes 9 4.31E-7
4 SGTC_65 0798-0905 3.86 35.0 µM 4.24E-6 calcium & mitochondrial duress 89 5.70E-5
5 SGTC_2843 9000894 3.81 45.5 µM 5.51E-6 13 6.96E-5
6 SGTC_2018 5133068 3.75 143.0 µM 7.50E-6 27 8.80E-5
7 SGTC_1585 2',4'-dihydroxychalcone 3.74 10.4 µM 7.85E-6 39 9.11E-5
8 SGTC_2839 9003951 3.52 26.0 µM 2.47E-5 19 2.18E-4
9 SGTC_2991 9074669 3.16 71.4 µM 1.34E-4 azole & statin 110 7.93E-4
10 SGTC_2568 diosmetin 3.05 100.0 µM 2.12E-4 67 0.00113
11 SGTC_686 1319-0111 3.04 510.0 µM 2.23E-4 60S ribosome export 63 0.00117
12 SGTC_2014 4013930 3.02 200.0 µM 2.41E-4 86 0.00124
13 SGTC_360 0957-0399 2.91 1.0 µM 3.96E-4 cell wall 108 0.00182
14 SGTC_2458 5808907 2.83 16.4 µM 5.46E-4 34 0.00233
15 SGTC_1810 st050138 2.76 53.0 µM 7.10E-4 PDR1 54 0.00285
16 SGTC_1808 st050063 2.72 61.5 µM 8.56E-4 66 0.00329
17 SGTC_2306 7482397 2.69 179.5 µM 9.36E-4 RPP1 & pyrimidine depletion 90 0.00352
18 SGTC_2342 7990637 2.67 118.9 µM 0.00105 RNA processing & uracil transport 118 0.00384
19 SGTC_705 1124-0212 2.64 310.0 µM 0.00116 78 0.00416
20 SGTC_319 1348-1596 2.58 45.5 µM 0.00145 RSC & ERG11 92 0.00493

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.328 7.39E-85 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.326 1.20E-83 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.321 2.57E-81 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.300 1.02E-70 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.284 3.07E-63 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.274 7.45E-59 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.270 7.70E-57 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.263 5.89E-54 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.255 5.05E-51 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.252 8.08E-50 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.251 3.66E-49 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.245 4.35E-47 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.242 8.77E-46 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.240 3.30E-45 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.239 1.12E-44 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner