YGR295C / COS6

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR295C / COS6

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-2.89|P-value:5.10E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.17|P-value:1.53E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-2.94|P-value:4.08E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.04|P-value:3.07E-4 ID:SGTC_447|Compound:ml7|FD-Score:2.86|P-value:6.32E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-2.94|P-value:4.11E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.89|P-value:5.71E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.63|P-value:2.15E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.42|P-value:5.85E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.41|P-value:6.20E-5 ID:SGTC_1748|Compound:st037455|FD-Score:2.87|P-value:6.08E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.10|P-value:2.39E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.12|P-value:2.22E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-5.68|P-value:5.46E-11 ID:SGTC_2354|Compound:9060492|FD-Score:3.73|P-value:1.32E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.76|P-value:1.11E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-3.00|P-value:3.13E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.20|P-value:1.35E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.16|P-value:1.59E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.18|P-value:1.70E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.23|P-value:1.17E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-3.11|P-value:2.03E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-2.85|P-value:5.91E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.29|P-value:1.08E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-4.24|P-value:7.43E-7 ID:SGTC_2876|Compound:9059903|FD-Score:3.58|P-value:2.78E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-3.75|P-value:1.01E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.77|P-value:9.02E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.41|P-value:6.16E-5 ID:SGTC_3100|Compound:9120536|FD-Score:3.35|P-value:7.97E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:-2.89|P-value:5.10E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.17|P-value:1.53E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-2.94|P-value:4.08E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.04|P-value:3.07E-4 ID:SGTC_447|Compound:ml7|FD-Score:2.86|P-value:6.32E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-2.94|P-value:4.11E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.89|P-value:5.71E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.63|P-value:2.15E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.42|P-value:5.85E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.41|P-value:6.20E-5 ID:SGTC_1748|Compound:st037455|FD-Score:2.87|P-value:6.08E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.10|P-value:2.39E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.12|P-value:2.22E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-5.68|P-value:5.46E-11 ID:SGTC_2354|Compound:9060492|FD-Score:3.73|P-value:1.32E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.76|P-value:1.11E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-3.00|P-value:3.13E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.20|P-value:1.35E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.16|P-value:1.59E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.18|P-value:1.70E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.23|P-value:1.17E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-3.11|P-value:2.03E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-2.85|P-value:5.91E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.29|P-value:1.08E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-4.24|P-value:7.43E-7 ID:SGTC_2876|Compound:9059903|FD-Score:3.58|P-value:2.78E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-3.75|P-value:1.01E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.77|P-value:9.02E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.41|P-value:6.16E-5 ID:SGTC_3100|Compound:9120536|FD-Score:3.35|P-value:7.97E-5

Top fitness defect scores for YGR295C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2568 diosmetin 3.76 100.0 µM 1.11E-5 28 8.39E-5
2 SGTC_2354 9060492 3.73 162.0 µM 1.32E-5 21 9.59E-5
3 SGTC_1034 k072-0165 3.63 12.7 µM 2.15E-5 Golgi 31 1.42E-4
4 SGTC_2876 9059903 3.58 26.0 µM 2.78E-5 18 1.74E-4
5 SGTC_1451 4152-0210 3.42 104.0 µM 5.85E-5 43 3.13E-4
6 SGTC_3037 9091026 3.41 49.5 µM 6.16E-5 NEO1-PIK1 165 3.26E-4
7 SGTC_1741 st038134 3.41 10.2 µM 6.20E-5 49 3.28E-4
8 SGTC_3100 9120536 3.35 49.5 µM 7.97E-5 24 4.00E-4
9 SGTC_2872 9044037 3.29 26.0 µM 1.08E-4 17 5.09E-4
10 SGTC_2819 7996655 3.18 46.4 µM 1.70E-4 46 7.31E-4
11 SGTC_1996 st072960 3.12 66.8 µM 2.22E-4 46 9.05E-4
12 SGTC_1979 st071809 3.10 45.3 µM 2.39E-4 RPP1 & pyrimidine depletion 48 9.60E-4
13 SGTC_317 4495-0002 3.04 170.0 µM 3.07E-4 35 0.00117
14 SGTC_1031 k035-0009 2.89 16.0 µM 5.71E-4 88 0.00192
15 SGTC_1748 st037455 2.87 53.6 µM 6.08E-4 96 0.00202
16 SGTC_447 ml7 2.86 120.0 µM 6.32E-4 NEO1-PIK1 77 0.00209
17 SGTC_2989 9073649 2.77 71.4 µM 9.02E-4 121 0.00277
18 SGTC_2799 7812892 2.75 81.8 µM 0.00100 superoxide 96 0.00302
19 SGTC_298 1391-0729 2.74 10.0 µM 0.00102 calcium & mitochondrial duress 62 0.00305
20 SGTC_3201 9113999 2.71 49.5 µM 0.00117 107 0.00341

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.219 1.04E-37 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.158 6.71E-20 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.138 8.34E-16 YJL045W YJL045W hom Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
0.135 4.16E-15 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.128 1.17E-13 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.127 1.41E-13 YGL041C-B_p YGL041C-B_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.126 2.60E-13 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.119 4.92E-12 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.119 6.22E-12 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.119 5.61E-12 YDR403W DIT1 hom Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
0.115 2.52E-11 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.115 2.77E-11 YOL154W ZPS1 hom Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
0.114 3.80E-11 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.113 4.87E-11 YOL125W TRM13 hom 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
0.111 1.20E-10 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p