Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHL003C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.230 | 2.56E-41 | YPL167C | REV3 | hom | Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair |
0.201 | 6.84E-32 | YHR130C_d | YHR130C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.196 | 3.19E-30 | YOR055W_d | YOR055W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.184 | 6.24E-27 | YML069W | POB3 | het | Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress |
0.177 | 3.90E-25 | YKL201C | MNN4 | hom | Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication |
0.165 | 8.08E-22 | YJR107W_p | YJR107W_p | hom | Putative lipase |
0.151 | 1.55E-18 | YKL116C | PRR1 | hom | Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor |
0.137 | 1.62E-15 | YER067C-A_d | YER067C-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W |
0.128 | 8.98E-14 | YKL218C | SRY1 | hom | 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity |
0.127 | 1.79E-13 | YGL017W | ATE1 | hom | Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway |
0.121 | 1.87E-12 | YOR034C | AKR2 | hom | Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication |
0.116 | 1.54E-11 | YCR061W_p | YCR061W_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation |
0.116 | 1.91E-11 | YGL082W_p | YGL082W_p | hom | Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene |
0.115 | 2.08E-11 | YDL027C_p | YDL027C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene |
0.115 | 2.22E-11 | YLR312W-A | MRPL15 | hom | Mitochondrial ribosomal protein of the large subunit |