YHL008C_p

Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL008C / YHL008C

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.26|P-value:7.54E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.17|P-value:3.67E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.20|P-value:2.29E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.87|P-value:1.20E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.81|P-value:1.06E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.34|P-value:7.70E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.66|P-value:1.88E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.42|P-value:9.27E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:4.26|P-value:1.77E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:-4.43|P-value:1.27E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.90|P-value:1.06E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.14|P-value:2.95E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:3.24|P-value:8.12E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.33|P-value:5.93E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.39|P-value:4.82E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.77|P-value:1.89E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.90|P-value:7.69E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.29|P-value:6.81E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.43|P-value:8.60E-6 ID:SGTC_1897|Compound:st060201|FD-Score:3.28|P-value:7.06E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.27|P-value:7.33E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.46|P-value:3.81E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.13|P-value:3.06E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.53|P-value:3.05E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.72|P-value:1.48E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.26|P-value:7.47E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.32|P-value:8.15E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.28|P-value:7.08E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.31|P-value:8.55E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.41|P-value:8.05E-8 ID:SGTC_2971|Compound:9092186|FD-Score:6.02|P-value:2.84E-9 ID:SGTC_2974|Compound:9094440|FD-Score:6.75|P-value:3.34E-11 ID:SGTC_3208|Compound:9114115|FD-Score:5.34|P-value:1.20E-7 ID:SGTC_3285|Compound:9112818|FD-Score:-3.83|P-value:1.39E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.30|P-value:6.72E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.26|P-value:7.54E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.17|P-value:3.67E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.20|P-value:2.29E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.87|P-value:1.20E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.81|P-value:1.06E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.34|P-value:7.70E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.66|P-value:1.88E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.42|P-value:9.27E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:4.26|P-value:1.77E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:-4.43|P-value:1.27E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.90|P-value:1.06E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.14|P-value:2.95E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:3.24|P-value:8.12E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.33|P-value:5.93E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.39|P-value:4.82E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.77|P-value:1.89E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.90|P-value:7.69E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.29|P-value:6.81E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.43|P-value:8.60E-6 ID:SGTC_1897|Compound:st060201|FD-Score:3.28|P-value:7.06E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.27|P-value:7.33E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.46|P-value:3.81E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.13|P-value:3.06E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.53|P-value:3.05E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.72|P-value:1.48E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.26|P-value:7.47E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.32|P-value:8.15E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.28|P-value:7.08E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.31|P-value:8.55E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.41|P-value:8.05E-8 ID:SGTC_2971|Compound:9092186|FD-Score:6.02|P-value:2.84E-9 ID:SGTC_2974|Compound:9094440|FD-Score:6.75|P-value:3.34E-11 ID:SGTC_3208|Compound:9114115|FD-Score:5.34|P-value:1.20E-7 ID:SGTC_3285|Compound:9112818|FD-Score:-3.83|P-value:1.39E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.30|P-value:6.72E-4

Top fitness defect scores for YHL008C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2974 9094440 6.75 9.7 µM 3.34E-11 ergosterol biosynthesis 5 7.15E-12
2 SGTC_2971 9092186 6.02 9.9 µM 2.84E-9 ergosterol biosynthesis 7 8.52E-10
3 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 5.41 13.2 µM 8.05E-8 6 3.10E-8
4 SGTC_3208 9114115 5.34 49.5 µM 1.20E-7 15 4.75E-8
5 SGTC_1021 4476-0760 4.77 85.3 µM 1.89E-6 10 9.16E-7
6 SGTC_1783 st039459 4.43 87.5 µM 8.60E-6 Golgi 14 4.64E-6
7 SGTC_674 0498-0004 4.42 451.0 µM 9.27E-6 heme requiring 14 5.03E-6
8 SGTC_697 0508-1955 4.26 564.0 µM 1.77E-5 24 1.00E-5
9 SGTC_93 0109-0045 4.20 59.2 µM 2.29E-5 DNA damage response 35 1.33E-5
10 SGTC_769 0302-0231 4.14 76.0 µM 2.95E-5 33 1.74E-5
11 SGTC_2238 6671620 4.13 73.2 µM 3.06E-5 23 1.81E-5
12 SGTC_1329 1447-1697 3.90 50.6 µM 7.69E-5 20 4.84E-5
13 SGTC_333 3486-0131 3.81 40.1 µM 1.06E-4 amide catabolism 14 6.82E-5
14 SGTC_2282 7944268 3.72 200.0 µM 1.48E-4 RPP1 & pyrimidine depletion 40 9.77E-5
15 SGTC_512 prima-1 3.66 270.0 µM 1.88E-4 DNA intercalators 32 1.26E-4
16 SGTC_2241 6772625 3.53 37.8 µM 3.05E-4 39 2.11E-4
17 SGTC_1956 st077085 3.46 54.0 µM 3.81E-4 32 2.68E-4
18 SGTC_1019 4262-0212 3.39 3.4 µM 4.82E-4 ergosterol depletion effects on membrane 97 3.44E-4
19 SGTC_891 0929-0073 3.33 133.0 µM 5.93E-4 44 4.29E-4
20 SGTC_3339 9145883 3.30 14.9 µM 6.72E-4 31 4.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.54E-8 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.095 3.60E-8 YOR033C EXO1 hom 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress
0.089 2.53E-7 YNL258C DSL1 het Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene
0.088 3.79E-7 YOL030W GAS5 hom 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
0.085 7.92E-7 YLR390W ECM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.43E-6 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.083 1.57E-6 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.080 3.47E-6 YGR053C_p YGR053C_p hom Putative protein of unknown function
0.077 8.49E-6 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.075 1.33E-5 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.074 1.73E-5 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.073 2.05E-5 YBR024W SCO2 hom Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.072 2.69E-5 YJL103C GSM1 hom Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
0.072 3.20E-5 YLR279W_d YLR279W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.071 3.61E-5 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog