YHL010C / ETP1

Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL010C / ETP1

Click on Significant Values for Screen Details ID:SGTC_358|Compound:0075-0058|FD-Score:2.96|P-value:2.83E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.84|P-value:4.51E-6 ID:SGTC_634|Compound:1611-4317|FD-Score:2.80|P-value:5.47E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:2.84|P-value:4.79E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:2.70|P-value:8.29E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:2.91|P-value:3.56E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:2.66|P-value:9.45E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.23|P-value:8.85E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.93|P-value:5.75E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-2.83|P-value:8.49E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.74|P-value:7.39E-6 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.90|P-value:3.73E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.25|P-value:1.52E-4 ID:SGTC_1590|Compound:st077108|FD-Score:2.94|P-value:3.14E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.09|P-value:2.93E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:2.92|P-value:3.39E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.14|P-value:8.46E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.16|P-value:1.20E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-2.83|P-value:8.53E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-2.84|P-value:8.14E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.91|P-value:2.99E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:2.72|P-value:7.66E-4 ID:SGTC_2788|Compound:5282734|FD-Score:2.99|P-value:2.47E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.03|P-value:3.89E-4 ID:SGTC_3287|Compound:9117173|FD-Score:2.79|P-value:5.84E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.94|P-value:3.15E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.06|P-value:1.87E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.58|P-value:1.64E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-4.14|P-value:1.87E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:2.96|P-value:2.83E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.84|P-value:4.51E-6 ID:SGTC_634|Compound:1611-4317|FD-Score:2.80|P-value:5.47E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:2.84|P-value:4.79E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:2.70|P-value:8.29E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:2.91|P-value:3.56E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:2.66|P-value:9.45E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.23|P-value:8.85E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.93|P-value:5.75E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-2.83|P-value:8.49E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.74|P-value:7.39E-6 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.90|P-value:3.73E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.25|P-value:1.52E-4 ID:SGTC_1590|Compound:st077108|FD-Score:2.94|P-value:3.14E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.09|P-value:2.93E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:2.92|P-value:3.39E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.14|P-value:8.46E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.16|P-value:1.20E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-2.83|P-value:8.53E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-2.84|P-value:8.14E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.91|P-value:2.99E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:2.72|P-value:7.66E-4 ID:SGTC_2788|Compound:5282734|FD-Score:2.99|P-value:2.47E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.03|P-value:3.89E-4 ID:SGTC_3287|Compound:9117173|FD-Score:2.79|P-value:5.84E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.94|P-value:3.15E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.06|P-value:1.87E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.58|P-value:1.64E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-4.14|P-value:1.87E-6

Top fitness defect scores for YHL010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1673 st016611 4.14 27.3 µM 8.46E-7 38 1.73E-5
2 SGTC_2407 paclitaxel 3.91 400.0 µM 2.99E-6 38 4.57E-5
3 SGTC_360 0957-0399 3.84 1.0 µM 4.51E-6 cell wall 48 6.27E-5
4 SGTC_1191 1487-1166 3.74 10.6 µM 7.39E-6 azole & statin 36 9.18E-5
5 SGTC_3330 9141424 3.58 71.4 µM 1.64E-5 amide catabolism 29 1.70E-4
6 SGTC_1004 4084-0029 3.23 199.0 µM 8.85E-5 49 6.22E-4
7 SGTC_1680 diphenhydramine 3.16 100.0 µM 1.20E-4 NEO1 66 7.86E-4
8 SGTC_3328 9140624 3.06 29.0 µM 1.87E-4 48 0.00111
9 SGTC_2788 5282734 2.99 71.4 µM 2.47E-4 109 0.00138
10 SGTC_358 0075-0058 2.96 9.4 µM 2.83E-4 131 0.00152
11 SGTC_1590 st077108 2.94 57.8 µM 3.14E-4 35 0.00165
12 SGTC_3297 9117502 2.94 71.4 µM 3.15E-4 41 0.00166
13 SGTC_1600 coumarin 106 2.92 71.1 µM 3.39E-4 74 0.00175
14 SGTC_803 4488-1585 2.91 147.0 µM 3.56E-4 56 0.00182
15 SGTC_1220 1838-0075 2.90 193.0 µM 3.73E-4 58 0.00189
16 SGTC_722 3534-0461 2.84 190.0 µM 4.79E-4 PDR1 96 0.00229
17 SGTC_634 1611-4317 2.80 11.2 µM 5.47E-4 ERG2 73 0.00254
18 SGTC_3287 9117173 2.79 37.1 µM 5.84E-4 60S ribosome export 27 0.00267
19 SGTC_2550 chrysin dimethyl ether 2.72 71.9 µM 7.66E-4 39 0.00329
20 SGTC_791 1348-1292 2.70 225.0 µM 8.29E-4 134 0.00350

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 3.44E-18 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
0.138 1.14E-15 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.137 1.69E-15 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
0.134 6.74E-15 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.117 1.14E-11 YMR254C_d YMR254C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.116 1.84E-11 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.113 4.37E-11 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.113 4.45E-11 YHR007C-A_p YHR007C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.106 8.04E-10 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.105 1.10E-9 YPR185W ATG13 hom Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
0.102 2.64E-9 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.102 2.76E-9 YLR446W_p YLR446W_p hom Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
0.098 1.47E-8 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.097 1.71E-8 YKR094C RPL40B hom Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
0.097 2.00E-8 YKL123W_d YKL123W_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4