YHL032C / GUT1

Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL032C / GUT1

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-3.76|P-value:1.82E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.40|P-value:6.63E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.45|P-value:3.54E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:4.02|P-value:4.14E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:3.35|P-value:4.92E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.27|P-value:6.48E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:4.94|P-value:7.00E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:12.70|P-value:4.91E-35 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.51|P-value:2.89E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.29|P-value:6.05E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.30|P-value:9.02E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.53|P-value:2.64E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.45|P-value:3.51E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.19|P-value:8.61E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-4.06|P-value:5.87E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:6.51|P-value:1.15E-10 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.99|P-value:7.79E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.76|P-value:1.12E-4 ID:SGTC_1630|Compound:st005209|FD-Score:6.15|P-value:1.07E-9 ID:SGTC_1683|Compound:st010134|FD-Score:-4.77|P-value:2.90E-6 ID:SGTC_1725|Compound:st036284|FD-Score:4.82|P-value:1.27E-6 ID:SGTC_1760|Compound:st045453|FD-Score:3.42|P-value:3.84E-4 ID:SGTC_1813|Compound:st051246|FD-Score:4.44|P-value:7.18E-6 ID:SGTC_1849|Compound:st056239|FD-Score:8.03|P-value:3.03E-15 ID:SGTC_2196|Compound:6573537|FD-Score:-3.31|P-value:8.76E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.99|P-value:4.59E-5 ID:SGTC_2302|Compound:7771753|FD-Score:4.41|P-value:8.17E-6 ID:SGTC_2432|Compound:5630864|FD-Score:3.43|P-value:3.77E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.36|P-value:7.49E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.39|P-value:4.27E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.76|P-value:1.12E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.53|P-value:2.67E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.43|P-value:3.74E-4 ID:SGTC_2786|Compound:7743617|FD-Score:5.64|P-value:1.89E-8 ID:SGTC_2787|Compound:5284540|FD-Score:14.00|P-value:6.43E-42 ID:SGTC_2788|Compound:5282734|FD-Score:-4.82|P-value:2.27E-6 ID:SGTC_2790|Compound:5423970|FD-Score:6.02|P-value:2.30E-9 ID:SGTC_2835|Compound:9006588|FD-Score:-3.51|P-value:4.52E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.27|P-value:9.93E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.46|P-value:3.34E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.56|P-value:2.34E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-3.55|P-value:3.94E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-5.04|P-value:8.13E-7 ID:SGTC_3302|Compound:9125395|FD-Score:-6.91|P-value:2.08E-11 ID:SGTC_3308|Compound:9128332|FD-Score:4.65|P-value:2.80E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.76|P-value:1.82E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.40|P-value:6.63E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.45|P-value:3.54E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:4.02|P-value:4.14E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:3.35|P-value:4.92E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.27|P-value:6.48E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:4.94|P-value:7.00E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:12.70|P-value:4.91E-35 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.51|P-value:2.89E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.29|P-value:6.05E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.30|P-value:9.02E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.53|P-value:2.64E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.45|P-value:3.51E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.19|P-value:8.61E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-4.06|P-value:5.87E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:6.51|P-value:1.15E-10 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.99|P-value:7.79E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.76|P-value:1.12E-4 ID:SGTC_1630|Compound:st005209|FD-Score:6.15|P-value:1.07E-9 ID:SGTC_1683|Compound:st010134|FD-Score:-4.77|P-value:2.90E-6 ID:SGTC_1725|Compound:st036284|FD-Score:4.82|P-value:1.27E-6 ID:SGTC_1760|Compound:st045453|FD-Score:3.42|P-value:3.84E-4 ID:SGTC_1813|Compound:st051246|FD-Score:4.44|P-value:7.18E-6 ID:SGTC_1849|Compound:st056239|FD-Score:8.03|P-value:3.03E-15 ID:SGTC_2196|Compound:6573537|FD-Score:-3.31|P-value:8.76E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.99|P-value:4.59E-5 ID:SGTC_2302|Compound:7771753|FD-Score:4.41|P-value:8.17E-6 ID:SGTC_2432|Compound:5630864|FD-Score:3.43|P-value:3.77E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.36|P-value:7.49E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.39|P-value:4.27E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.76|P-value:1.12E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.53|P-value:2.67E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.43|P-value:3.74E-4 ID:SGTC_2786|Compound:7743617|FD-Score:5.64|P-value:1.89E-8 ID:SGTC_2787|Compound:5284540|FD-Score:14.00|P-value:6.43E-42 ID:SGTC_2788|Compound:5282734|FD-Score:-4.82|P-value:2.27E-6 ID:SGTC_2790|Compound:5423970|FD-Score:6.02|P-value:2.30E-9 ID:SGTC_2835|Compound:9006588|FD-Score:-3.51|P-value:4.52E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.27|P-value:9.93E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.46|P-value:3.34E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.56|P-value:2.34E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-3.55|P-value:3.94E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-5.04|P-value:8.13E-7 ID:SGTC_3302|Compound:9125395|FD-Score:-6.91|P-value:2.08E-11 ID:SGTC_3308|Compound:9128332|FD-Score:4.65|P-value:2.80E-6

Top fitness defect scores for YHL032C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2787 5284540 14.00 71.4 µM 6.43E-42 1 1.44E-44
2 SGTC_359 0081-0058 12.70 15.9 µM 4.91E-35 60S ribosome export 1 3.37E-37
3 SGTC_1849 st056239 8.03 19.2 µM 3.03E-15 RPP1 & pyrimidine depletion 1 4.86E-16
4 SGTC_1008 4106-0037 6.51 6.0 µM 1.15E-10 PDR1 4 3.70E-11
5 SGTC_1630 st005209 6.15 31.3 µM 1.07E-9 2 3.96E-10
6 SGTC_2790 5423970 6.02 71.4 µM 2.30E-9 endomembrane recycling 26 8.99E-10
7 SGTC_2786 7743617 5.64 45.5 µM 1.89E-8 4 8.42E-9
8 SGTC_349 k015-0014 4.94 24.0 µM 7.00E-7 8 3.89E-7
9 SGTC_1725 st036284 4.82 20.6 µM 1.27E-6 14 7.36E-7
10 SGTC_3308 9128332 4.65 17.6 µM 2.80E-6 plasma membrane duress 55 1.70E-6
11 SGTC_1813 st051246 4.44 8.6 µM 7.18E-6 TSC3-RPN4 7 4.59E-6
12 SGTC_2302 7771753 4.41 200.0 µM 8.17E-6 32 5.27E-6
13 SGTC_154 3389-1638 4.02 511.1 µM 4.14E-5 23 2.93E-5
14 SGTC_2235 salicylic acid 3.99 500.0 µM 4.59E-5 6 3.27E-5
15 SGTC_1606 st000094 3.76 49.2 µM 1.12E-4 60S ribosome export 23 8.38E-5
16 SGTC_2706 st078239 3.76 82.5 µM 1.12E-4 15 8.38E-5
17 SGTC_3137 9097352 3.56 49.5 µM 2.34E-4 55 1.83E-4
18 SGTC_522 1273-0010 3.53 11.6 µM 2.64E-4 60S ribosome export 32 2.08E-4
19 SGTC_2764 methyldopa 3.53 94.7 µM 2.67E-4 28 2.10E-4
20 SGTC_421 streptovitacin 3.51 30.0 mM 2.89E-4 37 2.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 4.03E-17 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.144 4.07E-17 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.144 5.24E-17 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.138 1.22E-15 YHR007C-A_p YHR007C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.133 1.19E-14 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.124 6.64E-13 YOR095C RKI1 het Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
0.120 3.00E-12 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.119 4.04E-12 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.113 5.46E-11 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.112 7.72E-11 YPL224C MMT2 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
0.111 1.01E-10 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.111 1.25E-10 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.104 1.31E-9 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
0.104 1.37E-9 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.104 1.73E-9 YLR010C TEN1 het Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p