YHL034C / SBP1

Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL034C / SBP1

Click on Significant Values for Screen Details ID:SGTC_210|Compound:3551-0445|FD-Score:4.52|P-value:8.50E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.96|P-value:1.87E-17 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.60|P-value:6.60E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.57|P-value:7.62E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.71|P-value:4.81E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:5.39|P-value:5.74E-9 ID:SGTC_814|Compound:3342-0569|FD-Score:3.44|P-value:1.31E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.44|P-value:1.30E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:2.96|P-value:8.45E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.78|P-value:3.10E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:6.21|P-value:2.39E-11 ID:SGTC_1115|Compound:galangin|FD-Score:3.06|P-value:5.74E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.80|P-value:2.84E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.61|P-value:5.23E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.38|P-value:1.71E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.27|P-value:2.94E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.28|P-value:2.83E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.15|P-value:4.14E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.49|P-value:1.07E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.81|P-value:2.67E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.30|P-value:2.62E-6 ID:SGTC_1308|Compound:1187-1617|FD-Score:-3.40|P-value:1.78E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.73|P-value:3.86E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.22|P-value:3.18E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.85|P-value:2.66E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.33|P-value:2.08E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.73|P-value:2.78E-7 ID:SGTC_1754|Compound:st042065|FD-Score:3.22|P-value:3.19E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.12|P-value:5.36E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.73|P-value:3.77E-5 ID:SGTC_2366|Compound:9070441|FD-Score:3.27|P-value:2.65E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.79|P-value:2.96E-5 ID:SGTC_2421|Compound:5690543|FD-Score:-2.95|P-value:9.64E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.97|P-value:1.30E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.09|P-value:5.12E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.05|P-value:6.02E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.07|P-value:7.89E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.01|P-value:7.76E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.33|P-value:2.34E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.78|P-value:3.07E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.29|P-value:2.36E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.55|P-value:8.22E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.51|P-value:9.81E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-4.82|P-value:1.93E-7 ID:SGTC_3354|Compound:9151612|FD-Score:2.98|P-value:7.76E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.52|P-value:8.50E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.96|P-value:1.87E-17 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.60|P-value:6.60E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.57|P-value:7.62E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.71|P-value:4.81E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:5.39|P-value:5.74E-9 ID:SGTC_814|Compound:3342-0569|FD-Score:3.44|P-value:1.31E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.44|P-value:1.30E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:2.96|P-value:8.45E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.78|P-value:3.10E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:6.21|P-value:2.39E-11 ID:SGTC_1115|Compound:galangin|FD-Score:3.06|P-value:5.74E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.80|P-value:2.84E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.61|P-value:5.23E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.38|P-value:1.71E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.27|P-value:2.94E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.28|P-value:2.83E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.15|P-value:4.14E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.49|P-value:1.07E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.81|P-value:2.67E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.30|P-value:2.62E-6 ID:SGTC_1308|Compound:1187-1617|FD-Score:-3.40|P-value:1.78E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.73|P-value:3.86E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.22|P-value:3.18E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.85|P-value:2.66E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.33|P-value:2.08E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.73|P-value:2.78E-7 ID:SGTC_1754|Compound:st042065|FD-Score:3.22|P-value:3.19E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.12|P-value:5.36E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.73|P-value:3.77E-5 ID:SGTC_2366|Compound:9070441|FD-Score:3.27|P-value:2.65E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.79|P-value:2.96E-5 ID:SGTC_2421|Compound:5690543|FD-Score:-2.95|P-value:9.64E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.97|P-value:1.30E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.09|P-value:5.12E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.05|P-value:6.02E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.07|P-value:7.89E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.01|P-value:7.76E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.33|P-value:2.34E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.78|P-value:3.07E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.29|P-value:2.36E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.55|P-value:8.22E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.51|P-value:9.81E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-4.82|P-value:1.93E-7 ID:SGTC_3354|Compound:9151612|FD-Score:2.98|P-value:7.76E-4

Top fitness defect scores for YHL034C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 7.96 10.3 µM 1.87E-17 NEO1-PIK1 85 8.59E-16
2 SGTC_1003 4049-0218 6.21 100.0 µM 2.39E-11 2 2.58E-10
3 SGTC_594 1487-1584 5.39 10.8 µM 5.74E-9 7 3.53E-8
4 SGTC_1745 st081495 4.73 74.0 µM 2.78E-7 RNA processing & uracil transport 50 1.15E-6
5 SGTC_1179 1021-1431 4.61 9.3 µM 5.23E-7 25 2.03E-6
6 SGTC_210 3551-0445 4.52 56.8 µM 8.50E-7 50 3.14E-6
7 SGTC_902 1120-0002 4.44 2.1 µM 1.30E-6 azole & statin 34 4.59E-6
8 SGTC_1258 0671-0043 4.30 57.1 µM 2.62E-6 17 8.61E-6
9 SGTC_1219 1469-0211 4.27 33.1 µM 2.94E-6 17 9.57E-6
10 SGTC_2595 hexamethylquercetagetin 4.07 100.0 µM 7.89E-6 20 2.32E-5
11 SGTC_2498 4'-Methoxychalcone 3.97 54.6 µM 1.30E-5 RPP1 & pyrimidine depletion 36 3.62E-5
12 SGTC_1255 0566-0045 3.81 221.0 µM 2.67E-5 excess fatty acid 35 6.93E-5
13 SGTC_1173 0443-0020 3.80 122.0 µM 2.84E-5 TSC3-RPN4 39 7.32E-5
14 SGTC_2395 5646831 3.79 180.2 µM 2.96E-5 25 7.61E-5
15 SGTC_2900 5328528 3.78 85.3 µM 3.07E-5 Golgi 34 7.86E-5
16 SGTC_1000 4048-0884 3.78 8.7 µM 3.10E-5 copper-dependent oxidative stress 35 7.94E-5
17 SGTC_2058 5236698 3.73 133.0 µM 3.77E-5 32 9.46E-5
18 SGTC_1342 1486-1464 3.73 234.0 µM 3.86E-5 21 9.67E-5
19 SGTC_231 b-estradiol 3.60 524.0 µM 6.60E-5 10 1.57E-4
20 SGTC_474 dl-dihydrosphingosine 3.57 5.0 µM 7.62E-5 39 1.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.28E-32 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.193 1.19E-29 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.192 2.62E-29 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.189 3.18E-28 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.172 8.63E-24 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.162 3.30E-21 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.161 5.25E-21 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.158 3.75E-20 YOL159C-A YOL159C-A hom Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species
0.150 3.08E-18 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.141 1.82E-16 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.141 1.81E-16 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.139 6.87E-16 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.139 7.92E-16 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.138 9.01E-16 YJR097W JJJ3 hom Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4
0.138 1.27E-15 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p